Differences and similarities of high-resolution computed tomography features between pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients
BackgroundAccurately differentiating pneumocystis from cytomegalovirus pneumonia is crucial for correct therapy selection in AIDS patients. Hence, the goal of this study was to compare the computerized tomography (CT) features of pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients...
Gespeichert in:
| Veröffentlicht in: | Infectious diseases of poverty 2020-10, Vol.9 (1), p.149-149, Article 149 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 149 |
|---|---|
| container_issue | 1 |
| container_start_page | 149 |
| container_title | Infectious diseases of poverty |
| container_volume | 9 |
| creator | Du, Chun-Jing Liu, Jing-Yuan Chen, Hui Yan, Shuo Pu, Lin Xiong, Hao-Feng Xiang, Pan Li, Chuan-Sheng Zhang, Ming Xie, Ru-Ming Chen, Bu-Dong Li, Ang |
| description | BackgroundAccurately differentiating pneumocystis from cytomegalovirus pneumonia is crucial for correct therapy selection in AIDS patients. Hence, the goal of this study was to compare the computerized tomography (CT) features of pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients and identify clinical hallmarks to accurately distinguish these two pathologies.MethodsA total of 112 AIDS patients (78 with pneumocystis pneumonia and 34 cytomegalovirus pneumonia) at Beijing Ditan Hospital from January 2017 to May 2019 were included in this study. Two experienced chest radiologists retrospectively reviewed CT images for 17 features including ground-glass opacity, consolidation, nodules, and halo sign. Binary logistic regression analyses were conducted to identify the significant parameters that distinguished pneumocystis pneumonia from cytomegalovirus pneumonia. Correlations were analyzed by Pearson or Spearman correlation analyses. Result were considered significant if P |
| doi_str_mv | 10.1186/s40249-020-00768-2 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7586649</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A640295519</galeid><doaj_id>oai_doaj_org_article_10f48d23281e411ea52178f7b23fb628</doaj_id><sourcerecordid>A640295519</sourcerecordid><originalsourceid>FETCH-LOGICAL-c660t-b385be5e7f3d6cb0fd9bf89460212e3f33c8cdd94c99e34bad418df84f4605d23</originalsourceid><addsrcrecordid>eNqNkt9q2zAUxs3YWEvXF9jFMAzGYLiTZEmRbwYh3Z9AYRfbroUsHyUKtpRJckteZU87uWmzZOxi9oXlo9_3HenwFcVLjK4wFvx9pIjQpkIEVQjNuKjIk-KcoFxqGjZ7Oq0bVjHMyVlxGeMG5UcIiil-XpzVNUYcC3Fe_Lq2xkAApyGWynVltIPtVbDJ5oI35dqu1lWA6PsxWe9K7YftmKArkx_8KqjtelcaUGnMTNlCugNw5dbBOHi9i8nGhx9n1b2_3mUhrFTvb20Yj3etK-fL62_lVuXeLsUXxTOj-giXD9-L4senj98XX6qbr5-Xi_lNpTlHqWprwVpgMDN1x3WLTNe0RjSUI4IJ1KautdBd11DdNFDTVnUUi84IajLCOlJfFMu9b-fVRm6DHVTYSa-svC_4sJIqJKt7kBgZKrKECAwUY1CM4Jkws5bUpuVEZK8Pe6_t2A7Q6XyPoPoT09MdZ9dy5W_ljAnOaZMN3j4YBP9zhJjkYKOGvlcO_BgloYxyhgSfzv36L3Tjx-DyqDLFcVPngOA_VB45SOuMz331ZCrnPGeoYQxPba_-QeW3g8Fq78DYXD8RvDkSrEH1af2YkXgKkj2og48xgDkMAyM5JVnukyxzkuV9kuV0tVfHYzxIHnObAbEH7qD1Jmo7BfiA5aizDCEqptSThU1qOtfCjy5l6bv_l9a_AW4xEXM</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2461930241</pqid></control><display><type>article</type><title>Differences and similarities of high-resolution computed tomography features between pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SpringerNature Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><source>Springer Nature OA/Free Journals</source><creator>Du, Chun-Jing ; Liu, Jing-Yuan ; Chen, Hui ; Yan, Shuo ; Pu, Lin ; Xiong, Hao-Feng ; Xiang, Pan ; Li, Chuan-Sheng ; Zhang, Ming ; Xie, Ru-Ming ; Chen, Bu-Dong ; Li, Ang</creator><creatorcontrib>Du, Chun-Jing ; Liu, Jing-Yuan ; Chen, Hui ; Yan, Shuo ; Pu, Lin ; Xiong, Hao-Feng ; Xiang, Pan ; Li, Chuan-Sheng ; Zhang, Ming ; Xie, Ru-Ming ; Chen, Bu-Dong ; Li, Ang</creatorcontrib><description>BackgroundAccurately differentiating pneumocystis from cytomegalovirus pneumonia is crucial for correct therapy selection in AIDS patients. Hence, the goal of this study was to compare the computerized tomography (CT) features of pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients and identify clinical hallmarks to accurately distinguish these two pathologies.MethodsA total of 112 AIDS patients (78 with pneumocystis pneumonia and 34 cytomegalovirus pneumonia) at Beijing Ditan Hospital from January 2017 to May 2019 were included in this study. Two experienced chest radiologists retrospectively reviewed CT images for 17 features including ground-glass opacity, consolidation, nodules, and halo sign. Binary logistic regression analyses were conducted to identify the significant parameters that distinguished pneumocystis pneumonia from cytomegalovirus pneumonia. Correlations were analyzed by Pearson or Spearman correlation analyses. Result were considered significant if P<0.05.ResultsThe presence of consolidation, halo signs, and nodules (all P<0.05) were significantly more frequent in patients with cytomegalovirus pneumonia than in those with pneumocystis pneumonia. Small nodules (32.5% in cytomegalovirus pneumonia, 6.41% in pneumocystis pneumonia, P<0.001) without perilymphatic distribution were particularly common in patients with cytomegalovirus pneumonia. Large nodules were not found in any of patients with cytomegalovirus pneumonia. The presence of ground-glass opacity, reticulation, and bronchial wall thickening (all P>0.05) were common in both groups.ConclusionsAnalysis of consolidation, nodules, and halo signs may contribute to the differential diagnosis of pneumocystis pneumonia or cytomegalovirus pneumonia. However, some CT features considered typical in one or other diseases appear with similar frequency in both cohorts of AIDS patients. CT features are potentially useful for the differential diagnosis of pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients.</description><identifier>ISSN: 2095-5162</identifier><identifier>ISSN: 2049-9957</identifier><identifier>EISSN: 2049-9957</identifier><identifier>DOI: 10.1186/s40249-020-00768-2</identifier><identifier>PMID: 33106188</identifier><language>eng</language><publisher>LONDON: Springer Nature</publisher><subject>Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - complications ; Adult ; AIDS ; AIDS (Disease) ; AIDS patients ; Bronchoscopy ; Care and treatment ; CAT scans ; Correlation analysis ; Cysts ; Cytomegalovirus ; Cytomegalovirus pneumonia ; Diagnostic imaging ; Female ; Fever ; HIV ; HIV-1 ; HIV/AIDS ; Human immunodeficiency virus ; Humans ; Infections ; Infectious Diseases ; Leukopenia ; Life Sciences & Biomedicine ; Lymphocytes ; Male ; Medical diagnosis ; Middle Aged ; Neutrophils ; Parasitology ; Pneumocystis pneumonia ; Pneumonia ; Pneumonia, Pneumocystis - complications ; Pneumonia, Pneumocystis - diagnostic imaging ; Pneumonia, Pneumocystis - pathology ; Pneumonia, Viral - complications ; Pneumonia, Viral - diagnostic imaging ; Pneumonia, Viral - pathology ; Regression analysis ; Science & Technology ; Tomography ; Tropical Medicine ; Viral Load</subject><ispartof>Infectious diseases of poverty, 2020-10, Vol.9 (1), p.149-149, Article 149</ispartof><rights>COPYRIGHT 2020 BioMed Central Ltd.</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>7</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000588304800002</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c660t-b385be5e7f3d6cb0fd9bf89460212e3f33c8cdd94c99e34bad418df84f4605d23</citedby><cites>FETCH-LOGICAL-c660t-b385be5e7f3d6cb0fd9bf89460212e3f33c8cdd94c99e34bad418df84f4605d23</cites><orcidid>0000-0003-4680-7865</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586649/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586649/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33106188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Du, Chun-Jing</creatorcontrib><creatorcontrib>Liu, Jing-Yuan</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><creatorcontrib>Yan, Shuo</creatorcontrib><creatorcontrib>Pu, Lin</creatorcontrib><creatorcontrib>Xiong, Hao-Feng</creatorcontrib><creatorcontrib>Xiang, Pan</creatorcontrib><creatorcontrib>Li, Chuan-Sheng</creatorcontrib><creatorcontrib>Zhang, Ming</creatorcontrib><creatorcontrib>Xie, Ru-Ming</creatorcontrib><creatorcontrib>Chen, Bu-Dong</creatorcontrib><creatorcontrib>Li, Ang</creatorcontrib><title>Differences and similarities of high-resolution computed tomography features between pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients</title><title>Infectious diseases of poverty</title><addtitle>INFECT DIS POVERTY</addtitle><addtitle>Infect Dis Poverty</addtitle><description>BackgroundAccurately differentiating pneumocystis from cytomegalovirus pneumonia is crucial for correct therapy selection in AIDS patients. Hence, the goal of this study was to compare the computerized tomography (CT) features of pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients and identify clinical hallmarks to accurately distinguish these two pathologies.MethodsA total of 112 AIDS patients (78 with pneumocystis pneumonia and 34 cytomegalovirus pneumonia) at Beijing Ditan Hospital from January 2017 to May 2019 were included in this study. Two experienced chest radiologists retrospectively reviewed CT images for 17 features including ground-glass opacity, consolidation, nodules, and halo sign. Binary logistic regression analyses were conducted to identify the significant parameters that distinguished pneumocystis pneumonia from cytomegalovirus pneumonia. Correlations were analyzed by Pearson or Spearman correlation analyses. Result were considered significant if P<0.05.ResultsThe presence of consolidation, halo signs, and nodules (all P<0.05) were significantly more frequent in patients with cytomegalovirus pneumonia than in those with pneumocystis pneumonia. Small nodules (32.5% in cytomegalovirus pneumonia, 6.41% in pneumocystis pneumonia, P<0.001) without perilymphatic distribution were particularly common in patients with cytomegalovirus pneumonia. Large nodules were not found in any of patients with cytomegalovirus pneumonia. The presence of ground-glass opacity, reticulation, and bronchial wall thickening (all P>0.05) were common in both groups.ConclusionsAnalysis of consolidation, nodules, and halo signs may contribute to the differential diagnosis of pneumocystis pneumonia or cytomegalovirus pneumonia. However, some CT features considered typical in one or other diseases appear with similar frequency in both cohorts of AIDS patients. CT features are potentially useful for the differential diagnosis of pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Adult</subject><subject>AIDS</subject><subject>AIDS (Disease)</subject><subject>AIDS patients</subject><subject>Bronchoscopy</subject><subject>Care and treatment</subject><subject>CAT scans</subject><subject>Correlation analysis</subject><subject>Cysts</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus pneumonia</subject><subject>Diagnostic imaging</subject><subject>Female</subject><subject>Fever</subject><subject>HIV</subject><subject>HIV-1</subject><subject>HIV/AIDS</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious Diseases</subject><subject>Leukopenia</subject><subject>Life Sciences & Biomedicine</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Middle Aged</subject><subject>Neutrophils</subject><subject>Parasitology</subject><subject>Pneumocystis pneumonia</subject><subject>Pneumonia</subject><subject>Pneumonia, Pneumocystis - complications</subject><subject>Pneumonia, Pneumocystis - diagnostic imaging</subject><subject>Pneumonia, Pneumocystis - pathology</subject><subject>Pneumonia, Viral - complications</subject><subject>Pneumonia, Viral - diagnostic imaging</subject><subject>Pneumonia, Viral - pathology</subject><subject>Regression analysis</subject><subject>Science & Technology</subject><subject>Tomography</subject><subject>Tropical Medicine</subject><subject>Viral Load</subject><issn>2095-5162</issn><issn>2049-9957</issn><issn>2049-9957</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNqNkt9q2zAUxs3YWEvXF9jFMAzGYLiTZEmRbwYh3Z9AYRfbroUsHyUKtpRJckteZU87uWmzZOxi9oXlo9_3HenwFcVLjK4wFvx9pIjQpkIEVQjNuKjIk-KcoFxqGjZ7Oq0bVjHMyVlxGeMG5UcIiil-XpzVNUYcC3Fe_Lq2xkAApyGWynVltIPtVbDJ5oI35dqu1lWA6PsxWe9K7YftmKArkx_8KqjtelcaUGnMTNlCugNw5dbBOHi9i8nGhx9n1b2_3mUhrFTvb20Yj3etK-fL62_lVuXeLsUXxTOj-giXD9-L4senj98XX6qbr5-Xi_lNpTlHqWprwVpgMDN1x3WLTNe0RjSUI4IJ1KautdBd11DdNFDTVnUUi84IajLCOlJfFMu9b-fVRm6DHVTYSa-svC_4sJIqJKt7kBgZKrKECAwUY1CM4Jkws5bUpuVEZK8Pe6_t2A7Q6XyPoPoT09MdZ9dy5W_ljAnOaZMN3j4YBP9zhJjkYKOGvlcO_BgloYxyhgSfzv36L3Tjx-DyqDLFcVPngOA_VB45SOuMz331ZCrnPGeoYQxPba_-QeW3g8Fq78DYXD8RvDkSrEH1af2YkXgKkj2og48xgDkMAyM5JVnukyxzkuV9kuV0tVfHYzxIHnObAbEH7qD1Jmo7BfiA5aizDCEqptSThU1qOtfCjy5l6bv_l9a_AW4xEXM</recordid><startdate>20201026</startdate><enddate>20201026</enddate><creator>Du, Chun-Jing</creator><creator>Liu, Jing-Yuan</creator><creator>Chen, Hui</creator><creator>Yan, Shuo</creator><creator>Pu, Lin</creator><creator>Xiong, Hao-Feng</creator><creator>Xiang, Pan</creator><creator>Li, Chuan-Sheng</creator><creator>Zhang, Ming</creator><creator>Xie, Ru-Ming</creator><creator>Chen, Bu-Dong</creator><creator>Li, Ang</creator><general>Springer Nature</general><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4680-7865</orcidid></search><sort><creationdate>20201026</creationdate><title>Differences and similarities of high-resolution computed tomography features between pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients</title><author>Du, Chun-Jing ; Liu, Jing-Yuan ; Chen, Hui ; Yan, Shuo ; Pu, Lin ; Xiong, Hao-Feng ; Xiang, Pan ; Li, Chuan-Sheng ; Zhang, Ming ; Xie, Ru-Ming ; Chen, Bu-Dong ; Li, Ang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c660t-b385be5e7f3d6cb0fd9bf89460212e3f33c8cdd94c99e34bad418df84f4605d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Acquired Immunodeficiency Syndrome - complications</topic><topic>Adult</topic><topic>AIDS</topic><topic>AIDS (Disease)</topic><topic>AIDS patients</topic><topic>Bronchoscopy</topic><topic>Care and treatment</topic><topic>CAT scans</topic><topic>Correlation analysis</topic><topic>Cysts</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus pneumonia</topic><topic>Diagnostic imaging</topic><topic>Female</topic><topic>Fever</topic><topic>HIV</topic><topic>HIV-1</topic><topic>HIV/AIDS</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious Diseases</topic><topic>Leukopenia</topic><topic>Life Sciences & Biomedicine</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Middle Aged</topic><topic>Neutrophils</topic><topic>Parasitology</topic><topic>Pneumocystis pneumonia</topic><topic>Pneumonia</topic><topic>Pneumonia, Pneumocystis - complications</topic><topic>Pneumonia, Pneumocystis - diagnostic imaging</topic><topic>Pneumonia, Pneumocystis - pathology</topic><topic>Pneumonia, Viral - complications</topic><topic>Pneumonia, Viral - diagnostic imaging</topic><topic>Pneumonia, Viral - pathology</topic><topic>Regression analysis</topic><topic>Science & Technology</topic><topic>Tomography</topic><topic>Tropical Medicine</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Du, Chun-Jing</creatorcontrib><creatorcontrib>Liu, Jing-Yuan</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><creatorcontrib>Yan, Shuo</creatorcontrib><creatorcontrib>Pu, Lin</creatorcontrib><creatorcontrib>Xiong, Hao-Feng</creatorcontrib><creatorcontrib>Xiang, Pan</creatorcontrib><creatorcontrib>Li, Chuan-Sheng</creatorcontrib><creatorcontrib>Zhang, Ming</creatorcontrib><creatorcontrib>Xie, Ru-Ming</creatorcontrib><creatorcontrib>Chen, Bu-Dong</creatorcontrib><creatorcontrib>Li, Ang</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Infectious diseases of poverty</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Chun-Jing</au><au>Liu, Jing-Yuan</au><au>Chen, Hui</au><au>Yan, Shuo</au><au>Pu, Lin</au><au>Xiong, Hao-Feng</au><au>Xiang, Pan</au><au>Li, Chuan-Sheng</au><au>Zhang, Ming</au><au>Xie, Ru-Ming</au><au>Chen, Bu-Dong</au><au>Li, Ang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences and similarities of high-resolution computed tomography features between pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients</atitle><jtitle>Infectious diseases of poverty</jtitle><stitle>INFECT DIS POVERTY</stitle><addtitle>Infect Dis Poverty</addtitle><date>2020-10-26</date><risdate>2020</risdate><volume>9</volume><issue>1</issue><spage>149</spage><epage>149</epage><pages>149-149</pages><artnum>149</artnum><issn>2095-5162</issn><issn>2049-9957</issn><eissn>2049-9957</eissn><abstract>BackgroundAccurately differentiating pneumocystis from cytomegalovirus pneumonia is crucial for correct therapy selection in AIDS patients. Hence, the goal of this study was to compare the computerized tomography (CT) features of pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients and identify clinical hallmarks to accurately distinguish these two pathologies.MethodsA total of 112 AIDS patients (78 with pneumocystis pneumonia and 34 cytomegalovirus pneumonia) at Beijing Ditan Hospital from January 2017 to May 2019 were included in this study. Two experienced chest radiologists retrospectively reviewed CT images for 17 features including ground-glass opacity, consolidation, nodules, and halo sign. Binary logistic regression analyses were conducted to identify the significant parameters that distinguished pneumocystis pneumonia from cytomegalovirus pneumonia. Correlations were analyzed by Pearson or Spearman correlation analyses. Result were considered significant if P<0.05.ResultsThe presence of consolidation, halo signs, and nodules (all P<0.05) were significantly more frequent in patients with cytomegalovirus pneumonia than in those with pneumocystis pneumonia. Small nodules (32.5% in cytomegalovirus pneumonia, 6.41% in pneumocystis pneumonia, P<0.001) without perilymphatic distribution were particularly common in patients with cytomegalovirus pneumonia. Large nodules were not found in any of patients with cytomegalovirus pneumonia. The presence of ground-glass opacity, reticulation, and bronchial wall thickening (all P>0.05) were common in both groups.ConclusionsAnalysis of consolidation, nodules, and halo signs may contribute to the differential diagnosis of pneumocystis pneumonia or cytomegalovirus pneumonia. However, some CT features considered typical in one or other diseases appear with similar frequency in both cohorts of AIDS patients. CT features are potentially useful for the differential diagnosis of pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients.</abstract><cop>LONDON</cop><pub>Springer Nature</pub><pmid>33106188</pmid><doi>10.1186/s40249-020-00768-2</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4680-7865</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2095-5162 |
| ispartof | Infectious diseases of poverty, 2020-10, Vol.9 (1), p.149-149, Article 149 |
| issn | 2095-5162 2049-9957 2049-9957 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7586649 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerNature Journals; PubMed Central Open Access; PubMed Central; Springer Nature OA/Free Journals |
| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - complications Adult AIDS AIDS (Disease) AIDS patients Bronchoscopy Care and treatment CAT scans Correlation analysis Cysts Cytomegalovirus Cytomegalovirus pneumonia Diagnostic imaging Female Fever HIV HIV-1 HIV/AIDS Human immunodeficiency virus Humans Infections Infectious Diseases Leukopenia Life Sciences & Biomedicine Lymphocytes Male Medical diagnosis Middle Aged Neutrophils Parasitology Pneumocystis pneumonia Pneumonia Pneumonia, Pneumocystis - complications Pneumonia, Pneumocystis - diagnostic imaging Pneumonia, Pneumocystis - pathology Pneumonia, Viral - complications Pneumonia, Viral - diagnostic imaging Pneumonia, Viral - pathology Regression analysis Science & Technology Tomography Tropical Medicine Viral Load |
| title | Differences and similarities of high-resolution computed tomography features between pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T23%3A01%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differences%20and%20similarities%20of%20high-resolution%20computed%20tomography%20features%20between%20pneumocystis%20pneumonia%20and%20cytomegalovirus%20pneumonia%20in%20AIDS%20patients&rft.jtitle=Infectious%20diseases%20of%20poverty&rft.au=Du,%20Chun-Jing&rft.date=2020-10-26&rft.volume=9&rft.issue=1&rft.spage=149&rft.epage=149&rft.pages=149-149&rft.artnum=149&rft.issn=2095-5162&rft.eissn=2049-9957&rft_id=info:doi/10.1186/s40249-020-00768-2&rft_dat=%3Cgale_pubme%3EA640295519%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2461930241&rft_id=info:pmid/33106188&rft_galeid=A640295519&rft_doaj_id=oai_doaj_org_article_10f48d23281e411ea52178f7b23fb628&rfr_iscdi=true |