Phase separation by ssDNA binding protein controlled via protein–protein and protein–DNA interactions

Bacterial single-stranded (ss)DNA-binding proteins (SSB) are essential for the replication and maintenance of the genome. SSBs share a conserved ssDNA-binding domain, a less conserved intrinsically disordered linker (IDL), and a highly conserved C-terminal peptide (CTP) motif that mediates a wide ar...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-10, Vol.117 (42), p.26206-26217
Hauptverfasser:	Harami, Gábor M., Kovács, Zoltán J., Pancsa, Rita, Pálinkás, János, Baráth, Veronika, Tárnok, Krisztián, Málnási-Csizmadia, András, Kovács, Mihály
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cellular structure Condensates Deoxyribonucleic acid DNA DNA Damage DNA Repair DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism DNA-binding protein DNA-Binding Proteins - genetics DNA-Binding Proteins - isolation & purification DNA-Binding Proteins - metabolism E coli Escherichia coli - genetics Escherichia coli - growth & development Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - isolation & purification Escherichia coli Proteins - metabolism Genomes Liquid phases Liquid-Liquid Extraction - methods Localization Phase separation Protein arrays Protein Binding Protein interaction Proteins Single-stranded DNA Single-stranded DNA-binding protein Stoichiometry
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