Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo

Tumor necrosis factor-like cytokine 1A (TL1A, TNFSF15 ) is implicated in inflammatory bowel disease, modulating the location and severity of inflammation and fibrosis. TL1A expression is increased in inflamed mucosa and associated with fibrostenosing Crohn’s disease. Tl1a-overexpression in mice caus...

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Veröffentlicht in:	Scientific reports 2020-10, Vol.10 (1), p.18189-18189, Article 18189
Hauptverfasser:	Jacob, Noam, Kumagai, Kotaro, Abraham, Jay P., Shimodaira, Yosuke, Ye, Yuefang, Luu, Justin, Blackwood, Anna Y., Castanon, Sofi L., Stamps, Dalton T., Thomas, Lisa S., Gonsky, Rivkah, Shih, David Q., Michelsen, Kathrin S., Targan, Stephan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250 631/250/127 631/250/256 692/4020 692/4020/1503/257 Animals Colitis Collagen Crohn's disease Fibroblasts Fibroblasts - metabolism Fibrosis Fibrosis - metabolism Humanities and Social Sciences Ileitis Inflammation Inflammatory bowel disease Inflammatory bowel diseases Intestinal Diseases - metabolism Intestine Lymphocytes T Mice Mice, Transgenic Mucosa multidisciplinary Receptors, Tumor Necrosis Factor, Member 25 - genetics Receptors, Tumor Necrosis Factor, Member 25 - metabolism Ribonucleic acid RNA Science Science (multidisciplinary) Signal Transduction Tumor Necrosis Factor Ligand Superfamily Member 15 - genetics Tumor Necrosis Factor Ligand Superfamily Member 15 - metabolism
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