Fabrication of tri-layered electrospun polycaprolactone mats with improved sustained drug release profile

Modulation of initial burst and long term release from electrospun fibrous mats can be achieved by sandwiching the drug loaded mats between hydrophobic layers of fibrous polycaprolactone (PCL). Ibuprofen (IBU) loaded PCL fibrous mats (12% PCL-IBU) were sandwiched between fibrous polycaprolactone lay...

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Veröffentlicht in:	Scientific reports 2020-10, Vol.10 (1), p.18179-18179, Article 18179
Hauptverfasser:	Kamath, S. Manjunath, Sridhar, K., Jaison, D., Gopinath, V., Ibrahim, B. K. Mohamed, Gupta, Nilkantha, Sundaram, A., Sivaperumal, P., Padmapriya, S., Patil, S. Shantanu
Format:	Artikel
Sprache:	eng
Schlagworte:	631/61 631/80 639/301 Animals Cell Line Cytotoxicity Delayed-Action Preparations - chemistry Drug Liberation Fabrication Humanities and Social Sciences Hydrophobic and Hydrophilic Interactions Hydrophobicity Ibuprofen Ibuprofen - administration & dosage Ibuprofen - chemistry Long term Magnetic resonance spectroscopy Mice Microscopy, Electron, Scanning multidisciplinary NMR Nonsteroidal anti-inflammatory drugs Nuclear magnetic resonance Polycaprolactone Polyesters - chemistry Polymers Proton Magnetic Resonance Spectroscopy Scanning electron microscopy Science Science (multidisciplinary) Spectroscopy, Fourier Transform Infrared - methods Spectrum Analysis, Raman X-Ray Diffraction
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