Simultaneous Detection of Zinc and Its Pathway Metabolites Using MALDI MS Imaging of Prostate Tissue

Levels of zinc, along with its mechanistically related metabolites citrate and aspartate, are widely reported as reduced in prostate cancer compared to healthy tissue and are therefore pointed out as potential cancer biomarkers. Previously, it has only been possible to analyze zinc and metabolites b...

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Veröffentlicht in:	Analytical chemistry (Washington) 2020-02, Vol.92 (4), p.3171-3179
Hauptverfasser:	Andersen, Maria K, Krossa, Sebastian, Høiem, Therese S, Buchholz, Rebecca, Claes, Britt S. R, Balluff, Benjamin, Ellis, Shane R, Richardsen, Elin, Bertilsson, Helena, Heeren, Ron M. A, Bathen, Tone F, Karst, Uwe, Giskeødegård, Guro F, Tessem, May-Britt
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Aspartic Acid - metabolism Basale medisinske, odontologiske og veterinærmedisinske fag: 710 Basic medical, dental and veterinary science disciplines: 710 Biomarkers Chemistry Citrates - metabolism Citric acid Epithelium Humans Inductively coupled plasma Ionization Ions Laser ablation Male Mass spectrometry Mass spectroscopy Medical disciplines: 700 Medisinske Fag: 700 Metabolism Metabolites N-Acetylaspartate Prostate - cytology Prostate - metabolism Prostate - pathology Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Stroma Time Factors Tissues VDP Zinc Zinc - metabolism
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