Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases

With aging, the nervous system gradually undergoes degeneration. Increased oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction, and cell death are considered to be common pathophysiological mechanisms of various neurodegenerative diseases (NDDs) such as Alzheimer's disease...

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Veröffentlicht in:	International journal of molecular sciences 2020-10, Vol.21 (19), p.7174
Hauptverfasser:	Luo, Fang, Sandhu, Aaron F, Rungratanawanich, Wiramon, Williams, George E, Akbar, Mohammed, Zhou, Shuanhu, Song, Byoung-Joon, Wang, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Aging - metabolism Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - prevention & control Alzheimer's disease Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Amyotrophic Lateral Sclerosis - prevention & control Animals Antioxidants Antioxidants - metabolism Antioxidants - pharmacology Apoptosis Autophagy Autophagy (Cytology) Autophagy - drug effects Autophagy - genetics Autophagy-Related Proteins - agonists Autophagy-Related Proteins - genetics Autophagy-Related Proteins - metabolism Calcium channels Cell death Chemical compounds Circadian Rhythm - physiology Circadian rhythms Cytoplasm Degeneration Endoplasmic reticulum Etiology Health aspects Homeostasis Humans Huntington Disease - genetics Huntington Disease - metabolism Huntington Disease - pathology Huntington Disease - prevention & control Huntington's disease Huntingtons disease Kinases Melatonin Melatonin - biosynthesis Melatonin - pharmacology Membranes Mitochondria Nervous system Nervous System - drug effects Nervous System - metabolism Nervous System - pathology Neurodegeneration neurodegenerative diseases Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotection Neuroprotective Agents - metabolism Neuroprotective Agents - pharmacology Organelles Organophosphates Oxidative stress Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson Disease - prevention & control Parkinson's disease Pathogenesis Phagocytosis Pharmacology Physiology Pineal gland Pineal Gland - physiology Proteins Review
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