Placental Epigenome-Wide Association Study Identified Loci Associated with Childhood Adiposity at 3 Years of Age

The aim of this study was to identify placental DNA methylation (DNAm) variations associated with adiposity at 3 years of age. We quantified placental DNAm using the Infinium MethylationEPIC BeadChips. We assessed associations between DNAm at single-CpGs and skinfold thickness using robust linear re...

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Veröffentlicht in:	International journal of molecular sciences 2020-10, Vol.21 (19), p.7201
Hauptverfasser:	Gagné-Ouellet, Valérie, Breton, Edith, Thibeault, Kathrine, Fortin, Carol-Ann, Desgagné, Véronique, Girard Tremblay, Élise, Cardenas, Andres, Guérin, Renée, Perron, Patrice, Hivert, Marie-France, Bouchard, Luigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adiposity - genetics Adult Biomarkers Body mass index Child, Preschool Childhood Children Chromosome 1 Chromosomes Deoxyribonucleic acid Deposition Diabetes in children DNA DNA methylation DNA Methylation - genetics Epigenetic inheritance Epigenetics Epigenome - genetics Female Fetuses Gene expression Genetic aspects Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Gestational age Glucose Health aspects Heterogeneity Humans Male Metabolism Mothers mRNA Obesity Pediatric Obesity - genetics Pediatric Obesity - pathology Placenta Placenta - metabolism Placenta - pathology Pregnancy Regression analysis Skinfold Thickness Thickness
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