Chaperone Sigma1R and Antidepressant Effect

This review analyzes the current scientific literature on the role of the Sigma1R chaperone in the pathogenesis of depressive disorders and pharmacodynamics of antidepressants. As a result of ligand activation, Sigma1R is capable of intracellular translocation from the endoplasmic reticulum (ER) int...

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Veröffentlicht in:	International journal of molecular sciences 2020-10, Vol.21 (19), p.7088
Hauptverfasser:	Voronin, Mikhail V, Vakhitova, Yulia V, Seredenin, Sergei B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressants Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Binding sites Cell membranes Clinical medicine Depressive Disorder - drug therapy Depressive Disorder - metabolism Endoplasmic reticulum Health aspects Humans Ion channels Laboratory animals Ligands Lipids Mental depression Mental disorders Mitochondria Molecular chaperones Molecular modelling Pathogenesis Pharmacodynamics Proteins Psychotropic drugs Receptor mechanisms Receptors, sigma - physiology Review Sensors Sigma-1 Receptor Transcription factors
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