The Down-Regulation of Clusterin Expression Enhances the αSynuclein Aggregation Process

Parkinson's Disease (PD) is a progressive neurodegenerative disease characterized by the presence of proteinaceous aggregates of αSynuclein (αSyn) in the dopaminergic neurons. Chaperones are key components of the proteostasis network that are able to counteract αSyn's aggregation, as well...

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Veröffentlicht in:	International journal of molecular sciences 2020-09, Vol.21 (19), p.7181
Hauptverfasser:	Lenzi, Chiara, Ramazzina, Ileana, Russo, Isabella, Filippini, Alice, Bettuzzi, Saverio, Rizzi, Federica
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates alpha-Synuclein - genetics Alzheimer's disease Amyloid beta-Peptides - genetics Brain research Cell viability Chaperones Clusterin Clusterin - genetics Dopamine receptors Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology Gene Expression Regulation - genetics Heat shock proteins Heat-Shock Proteins - genetics Hsp27 protein HSP70 Heat-Shock Proteins - genetics Hsp70 protein HSP90 Heat-Shock Proteins - genetics Hsp90 protein Humans Immunoprecipitation Molecular Chaperones - genetics Molecular interactions Molecular weight Neuroblastoma Parkinson Disease - genetics Parkinson Disease - pathology Parkinson's disease Pathogenesis Proteasomes Protein Aggregation, Pathological - genetics Protein Aggregation, Pathological - pathology Protein folding Unfolded Protein Response - genetics
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