Effects of Fluoride Long-Term Exposure over the Cerebellum: Global Proteomic Profile, Oxidative Biochemistry, Cell Density, and Motor Behavior Evaluation

Although the literature does not provide evidence of health risks from exposure to fluoride (F) in therapeutic doses, questions remain about the effects of long-term and high-dose use on the function of the central nervous system. The objective of this study was to investigate the effect of long-ter...

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Veröffentlicht in:	International journal of molecular sciences 2020-10, Vol.21 (19), p.7297
Hauptverfasser:	Lopes, Géssica Oliveira, Martins Ferreira, Maria Karolina, Davis, Lodinikki, Bittencourt, Leonardo Oliveira, Bragança Aragão, Walessa Alana, Dionizio, Aline, Rabelo Buzalaf, Marília Afonso, Crespo-Lopez, Maria Elena, Maia, Cristiane Socorro Ferraz, Lima, Rafael Rodrigues
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cognition Animals Antioxidants Antioxidants - metabolism Biochemistry Cell death Cell density Central nervous system Central Nervous System - drug effects Central Nervous System - metabolism Cerebellum Cerebellum - drug effects Cerebellum - metabolism Exploratory behavior Exposure Fluorides Fluorides - adverse effects Fluorides - pharmacology Fluorosis Health aspects Humans Lipid peroxidation Lipid Peroxidation - drug effects Lipids Mice Motor ability Oxidation-Reduction - drug effects Oxidative stress Oxidative Stress - drug effects Peroxides - antagonists & inhibitors Peroxyl radicals Proteins Proteomics - methods Sodium fluoride Sodium Fluoride - pharmacology
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