Antibacterial Activity of Selected Essential Oil Compounds Alone and in Combination with β-Lactam Antibiotics Against MRSA Strains
This study aimed to determine the effect of selected essential oil compounds (EOCs) on the antibacterial activity of β-lactam antibiotics (βLAs) against methicillin-resistant (MRSA) strains. The following parameters were studied: antibiotic susceptibility testing, detection of gene and evaluation of...
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| Veröffentlicht in: | International journal of molecular sciences 2020-09, Vol.21 (19), p.7106 |
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| creator | Kwiatkowski, Paweł Łopusiewicz, Łukasz Pruss, Agata Kostek, Mateusz Sienkiewicz, Monika Bonikowski, Radosław Wojciechowska-Koszko, Iwona Dołęgowska, Barbara |
| description | This study aimed to determine the effect of selected essential oil compounds (EOCs) on the antibacterial activity of β-lactam antibiotics (βLAs) against methicillin-resistant
(MRSA) strains. The following parameters were studied: antibiotic susceptibility testing, detection of
gene and evaluation of genotypic relativity of isolates using molecular techniques, analysis of chemical composition applying Fourier-transform infrared (FTIR) spectroscopy, and determination of antibacterial activity of EOCs alone and in combination with βLAs against MRSA strains using microdilution and checkerboard methods. It was found that all isolates expressed MRSA and resistance phenotypes for macrolides, lincosamides, and streptogramins B. All isolates harbored the
gene and belonged to three distinct genotypes. Eight of the 10 EOCs showed efficient antimicrobial activity against the MRSA reference strain. The analysis of interaction between EOCs and βLAs against the MRSA reference strain revealed a synergistic and additive effect of the following combinations: methicillin (Met)-linalyl acetate (LinAc), penicillin G (Pen)-1,8-cineole (Cin), and Pen-LinAc. Analysis of EOC-βLA interactions showed a synergistic and additive effect in the following combinations: Met-LinAc (against low- and high-level βLAs resistance strains), Pen-Cin, and Pen-LinAc (against low-level βLAs resistance strains). It was also confirmed that changes in phosphodiester, -OH, -CH
and -CH
groups may change the interactions with βLAs. Moreover, the presence of two CH
O- moieties in the Met molecule could also play a key role in the synergistic and additive mechanism of LinAc action with Met against MRSA strains. Direct therapy using a Met-LinAc combination may become an alternative treatment method for staphylococcal infections caused by MRSA. However, this unconventional therapy must be preceded by numerous cytotoxicity tests. |
| doi_str_mv | 10.3390/ijms21197106 |
| format | Article |
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(MRSA) strains. The following parameters were studied: antibiotic susceptibility testing, detection of
gene and evaluation of genotypic relativity of isolates using molecular techniques, analysis of chemical composition applying Fourier-transform infrared (FTIR) spectroscopy, and determination of antibacterial activity of EOCs alone and in combination with βLAs against MRSA strains using microdilution and checkerboard methods. It was found that all isolates expressed MRSA and resistance phenotypes for macrolides, lincosamides, and streptogramins B. All isolates harbored the
gene and belonged to three distinct genotypes. Eight of the 10 EOCs showed efficient antimicrobial activity against the MRSA reference strain. The analysis of interaction between EOCs and βLAs against the MRSA reference strain revealed a synergistic and additive effect of the following combinations: methicillin (Met)-linalyl acetate (LinAc), penicillin G (Pen)-1,8-cineole (Cin), and Pen-LinAc. Analysis of EOC-βLA interactions showed a synergistic and additive effect in the following combinations: Met-LinAc (against low- and high-level βLAs resistance strains), Pen-Cin, and Pen-LinAc (against low-level βLAs resistance strains). It was also confirmed that changes in phosphodiester, -OH, -CH
and -CH
groups may change the interactions with βLAs. Moreover, the presence of two CH
O- moieties in the Met molecule could also play a key role in the synergistic and additive mechanism of LinAc action with Met against MRSA strains. Direct therapy using a Met-LinAc combination may become an alternative treatment method for staphylococcal infections caused by MRSA. However, this unconventional therapy must be preceded by numerous cytotoxicity tests.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21197106</identifier><identifier>PMID: 32993130</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acetic acid ; Amides ; Anti-Bacterial Agents - pharmacology ; Antibacterial activity ; Antibiotics ; Antimicrobial activity ; Antimicrobial agents ; beta-Lactams - pharmacology ; Chemical composition ; Cineole ; Cytotoxicity ; Drug resistance ; Drug Synergism ; Essential oils ; Genotypes ; Humans ; Infrared analysis ; Linalyl acetate ; Lincosamides ; MecA protein ; Metabolites ; Methicillin ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Microbial Sensitivity Tests ; Oils & fats ; Oils, Volatile - pharmacology ; Optimization ; Penicillin ; Phenotypes ; Relativity ; Spectrum analysis ; Staphylococcal Infections - drug therapy ; Staphylococcus aureus ; Staphylococcus infections ; Strains (organisms) ; Streptogramins ; β-Lactam antibiotics</subject><ispartof>International journal of molecular sciences, 2020-09, Vol.21 (19), p.7106</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-993018b1d01c9668f80d60a13c26c19c7b2858ff39ae7ddd1ebe81fcfa7682c03</citedby><cites>FETCH-LOGICAL-c412t-993018b1d01c9668f80d60a13c26c19c7b2858ff39ae7ddd1ebe81fcfa7682c03</cites><orcidid>0000-0003-4887-4113 ; 0000-0001-9499-8366 ; 0000-0003-3327-8984 ; 0000-0003-0016-0541 ; 0000-0001-7493-4656 ; 0000-0002-9823-4176 ; 0000-0003-3138-1013</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582342/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582342/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32993130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwiatkowski, Paweł</creatorcontrib><creatorcontrib>Łopusiewicz, Łukasz</creatorcontrib><creatorcontrib>Pruss, Agata</creatorcontrib><creatorcontrib>Kostek, Mateusz</creatorcontrib><creatorcontrib>Sienkiewicz, Monika</creatorcontrib><creatorcontrib>Bonikowski, Radosław</creatorcontrib><creatorcontrib>Wojciechowska-Koszko, Iwona</creatorcontrib><creatorcontrib>Dołęgowska, Barbara</creatorcontrib><title>Antibacterial Activity of Selected Essential Oil Compounds Alone and in Combination with β-Lactam Antibiotics Against MRSA Strains</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>This study aimed to determine the effect of selected essential oil compounds (EOCs) on the antibacterial activity of β-lactam antibiotics (βLAs) against methicillin-resistant
(MRSA) strains. The following parameters were studied: antibiotic susceptibility testing, detection of
gene and evaluation of genotypic relativity of isolates using molecular techniques, analysis of chemical composition applying Fourier-transform infrared (FTIR) spectroscopy, and determination of antibacterial activity of EOCs alone and in combination with βLAs against MRSA strains using microdilution and checkerboard methods. It was found that all isolates expressed MRSA and resistance phenotypes for macrolides, lincosamides, and streptogramins B. All isolates harbored the
gene and belonged to three distinct genotypes. Eight of the 10 EOCs showed efficient antimicrobial activity against the MRSA reference strain. The analysis of interaction between EOCs and βLAs against the MRSA reference strain revealed a synergistic and additive effect of the following combinations: methicillin (Met)-linalyl acetate (LinAc), penicillin G (Pen)-1,8-cineole (Cin), and Pen-LinAc. Analysis of EOC-βLA interactions showed a synergistic and additive effect in the following combinations: Met-LinAc (against low- and high-level βLAs resistance strains), Pen-Cin, and Pen-LinAc (against low-level βLAs resistance strains). It was also confirmed that changes in phosphodiester, -OH, -CH
and -CH
groups may change the interactions with βLAs. Moreover, the presence of two CH
O- moieties in the Met molecule could also play a key role in the synergistic and additive mechanism of LinAc action with Met against MRSA strains. Direct therapy using a Met-LinAc combination may become an alternative treatment method for staphylococcal infections caused by MRSA. However, this unconventional therapy must be preceded by numerous cytotoxicity tests.</description><subject>Acetic acid</subject><subject>Amides</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial activity</subject><subject>Antibiotics</subject><subject>Antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>beta-Lactams - pharmacology</subject><subject>Chemical composition</subject><subject>Cineole</subject><subject>Cytotoxicity</subject><subject>Drug resistance</subject><subject>Drug Synergism</subject><subject>Essential oils</subject><subject>Genotypes</subject><subject>Humans</subject><subject>Infrared analysis</subject><subject>Linalyl acetate</subject><subject>Lincosamides</subject><subject>MecA protein</subject><subject>Metabolites</subject><subject>Methicillin</subject><subject>Methicillin-Resistant Staphylococcus aureus - drug effects</subject><subject>Microbial Sensitivity Tests</subject><subject>Oils & fats</subject><subject>Oils, Volatile - pharmacology</subject><subject>Optimization</subject><subject>Penicillin</subject><subject>Phenotypes</subject><subject>Relativity</subject><subject>Spectrum analysis</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus infections</subject><subject>Strains (organisms)</subject><subject>Streptogramins</subject><subject>β-Lactam antibiotics</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpVkc1uGyEUhVHVqknT7rqukLrtJFywGdhUGllJWslRpLpdIwaYBGsGXMCJsu4b5UHyTMXNj9wVcO_HuefqIPQRyDFjkpz49ZQpgGyB8FfoEGaUNoTw9vXe_QC9y3lNCGV0Lt-iA0alZMDIIfrTheJ7bYpLXo-4M8Xf-HKH44BXbnS1bvFpzq5StX3pR7yI0yZug824G2NwWAeLfdiVex908THgW1-u8cN9s6y6esL_RvhYvKl_rrQPueCLH6sOr0ravd6jN4Mes_vwdB6hX2enPxffmuXl-fdFt2zMDGhpqmUCogdLwEjOxSCI5UQDM5QbkKbtqZiLYWBSu9ZaC653AgYz6JYLagg7Ql8fdTfbfnLW1KWSHtUm-UmnOxW1V_93gr9WV_FGtXNB2YxWgc9PAin-3rpc1DpuU6ieFZ3PBJcEOFTqyyNlUsw5ueFlAhC1i0ztR1bxT_uuXuDnjNhfrhOVKg</recordid><startdate>20200926</startdate><enddate>20200926</enddate><creator>Kwiatkowski, Paweł</creator><creator>Łopusiewicz, Łukasz</creator><creator>Pruss, Agata</creator><creator>Kostek, Mateusz</creator><creator>Sienkiewicz, Monika</creator><creator>Bonikowski, Radosław</creator><creator>Wojciechowska-Koszko, Iwona</creator><creator>Dołęgowska, Barbara</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4887-4113</orcidid><orcidid>https://orcid.org/0000-0001-9499-8366</orcidid><orcidid>https://orcid.org/0000-0003-3327-8984</orcidid><orcidid>https://orcid.org/0000-0003-0016-0541</orcidid><orcidid>https://orcid.org/0000-0001-7493-4656</orcidid><orcidid>https://orcid.org/0000-0002-9823-4176</orcidid><orcidid>https://orcid.org/0000-0003-3138-1013</orcidid></search><sort><creationdate>20200926</creationdate><title>Antibacterial Activity of Selected Essential Oil Compounds Alone and in Combination with β-Lactam Antibiotics Against MRSA Strains</title><author>Kwiatkowski, Paweł ; Łopusiewicz, Łukasz ; Pruss, Agata ; Kostek, Mateusz ; Sienkiewicz, Monika ; Bonikowski, Radosław ; Wojciechowska-Koszko, Iwona ; Dołęgowska, Barbara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-993018b1d01c9668f80d60a13c26c19c7b2858ff39ae7ddd1ebe81fcfa7682c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acetic acid</topic><topic>Amides</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial activity</topic><topic>Antibiotics</topic><topic>Antimicrobial activity</topic><topic>Antimicrobial agents</topic><topic>beta-Lactams - pharmacology</topic><topic>Chemical composition</topic><topic>Cineole</topic><topic>Cytotoxicity</topic><topic>Drug resistance</topic><topic>Drug Synergism</topic><topic>Essential oils</topic><topic>Genotypes</topic><topic>Humans</topic><topic>Infrared analysis</topic><topic>Linalyl acetate</topic><topic>Lincosamides</topic><topic>MecA protein</topic><topic>Metabolites</topic><topic>Methicillin</topic><topic>Methicillin-Resistant Staphylococcus aureus - drug effects</topic><topic>Microbial Sensitivity Tests</topic><topic>Oils & fats</topic><topic>Oils, Volatile - pharmacology</topic><topic>Optimization</topic><topic>Penicillin</topic><topic>Phenotypes</topic><topic>Relativity</topic><topic>Spectrum analysis</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus infections</topic><topic>Strains (organisms)</topic><topic>Streptogramins</topic><topic>β-Lactam antibiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwiatkowski, Paweł</creatorcontrib><creatorcontrib>Łopusiewicz, Łukasz</creatorcontrib><creatorcontrib>Pruss, Agata</creatorcontrib><creatorcontrib>Kostek, Mateusz</creatorcontrib><creatorcontrib>Sienkiewicz, Monika</creatorcontrib><creatorcontrib>Bonikowski, Radosław</creatorcontrib><creatorcontrib>Wojciechowska-Koszko, Iwona</creatorcontrib><creatorcontrib>Dołęgowska, Barbara</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwiatkowski, Paweł</au><au>Łopusiewicz, Łukasz</au><au>Pruss, Agata</au><au>Kostek, Mateusz</au><au>Sienkiewicz, Monika</au><au>Bonikowski, Radosław</au><au>Wojciechowska-Koszko, Iwona</au><au>Dołęgowska, Barbara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibacterial Activity of Selected Essential Oil Compounds Alone and in Combination with β-Lactam Antibiotics Against MRSA Strains</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2020-09-26</date><risdate>2020</risdate><volume>21</volume><issue>19</issue><spage>7106</spage><pages>7106-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>This study aimed to determine the effect of selected essential oil compounds (EOCs) on the antibacterial activity of β-lactam antibiotics (βLAs) against methicillin-resistant
(MRSA) strains. The following parameters were studied: antibiotic susceptibility testing, detection of
gene and evaluation of genotypic relativity of isolates using molecular techniques, analysis of chemical composition applying Fourier-transform infrared (FTIR) spectroscopy, and determination of antibacterial activity of EOCs alone and in combination with βLAs against MRSA strains using microdilution and checkerboard methods. It was found that all isolates expressed MRSA and resistance phenotypes for macrolides, lincosamides, and streptogramins B. All isolates harbored the
gene and belonged to three distinct genotypes. Eight of the 10 EOCs showed efficient antimicrobial activity against the MRSA reference strain. The analysis of interaction between EOCs and βLAs against the MRSA reference strain revealed a synergistic and additive effect of the following combinations: methicillin (Met)-linalyl acetate (LinAc), penicillin G (Pen)-1,8-cineole (Cin), and Pen-LinAc. Analysis of EOC-βLA interactions showed a synergistic and additive effect in the following combinations: Met-LinAc (against low- and high-level βLAs resistance strains), Pen-Cin, and Pen-LinAc (against low-level βLAs resistance strains). It was also confirmed that changes in phosphodiester, -OH, -CH
and -CH
groups may change the interactions with βLAs. Moreover, the presence of two CH
O- moieties in the Met molecule could also play a key role in the synergistic and additive mechanism of LinAc action with Met against MRSA strains. Direct therapy using a Met-LinAc combination may become an alternative treatment method for staphylococcal infections caused by MRSA. However, this unconventional therapy must be preceded by numerous cytotoxicity tests.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32993130</pmid><doi>10.3390/ijms21197106</doi><orcidid>https://orcid.org/0000-0003-4887-4113</orcidid><orcidid>https://orcid.org/0000-0001-9499-8366</orcidid><orcidid>https://orcid.org/0000-0003-3327-8984</orcidid><orcidid>https://orcid.org/0000-0003-0016-0541</orcidid><orcidid>https://orcid.org/0000-0001-7493-4656</orcidid><orcidid>https://orcid.org/0000-0002-9823-4176</orcidid><orcidid>https://orcid.org/0000-0003-3138-1013</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular sciences, 2020-09, Vol.21 (19), p.7106 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Acetic acid Amides Anti-Bacterial Agents - pharmacology Antibacterial activity Antibiotics Antimicrobial activity Antimicrobial agents beta-Lactams - pharmacology Chemical composition Cineole Cytotoxicity Drug resistance Drug Synergism Essential oils Genotypes Humans Infrared analysis Linalyl acetate Lincosamides MecA protein Metabolites Methicillin Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Oils & fats Oils, Volatile - pharmacology Optimization Penicillin Phenotypes Relativity Spectrum analysis Staphylococcal Infections - drug therapy Staphylococcus aureus Staphylococcus infections Strains (organisms) Streptogramins β-Lactam antibiotics |
| title | Antibacterial Activity of Selected Essential Oil Compounds Alone and in Combination with β-Lactam Antibiotics Against MRSA Strains |
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