An injectable self-healing anesthetic glycolipid-based oleogel with antibiofilm and diabetic wound skin repair properties

Globally, wound infections are considered as one of the major healthcare problems owing to the delayed healing process in diabetic patients and microbial contamination. Thus, the development of advanced materials for wound skin repair is of great research interest. Even though several biomaterials w...

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Veröffentlicht in:Scientific reports 2020-10, Vol.10 (1), p.18017-18017, Article 18017
Hauptverfasser: Prasad, Yadavali Siva, Miryala, Sandeep, Lalitha, Krishnamoorthy, Saritha, Balasubramani, Maheswari, C. Uma, Sridharan, Vellaisamy, Srinandan, C. S., Nagarajan, Subbiah
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container_title Scientific reports
container_volume 10
creator Prasad, Yadavali Siva
Miryala, Sandeep
Lalitha, Krishnamoorthy
Saritha, Balasubramani
Maheswari, C. Uma
Sridharan, Vellaisamy
Srinandan, C. S.
Nagarajan, Subbiah
description Globally, wound infections are considered as one of the major healthcare problems owing to the delayed healing process in diabetic patients and microbial contamination. Thus, the development of advanced materials for wound skin repair is of great research interest. Even though several biomaterials were identified as wound healing agents, gel-based scaffolds derived from either polymer or small molecules have displayed promising wound closure mechanism. Herein, for the first time, we report an injectable and self-healing self-assembled anesthetic oleogel derived from glycolipid, which exhibits antibiofilm and wound closure performance in diabetic rat. Glycolipid derived by the reaction of hydrophobic vinyl ester with α-chloralose in the presence of novozyme 435 undergoes spontaneous self-assembly in paraffin oil furnished an oleogel displaying self-healing behavior. In addition, we have prepared composite gel by encapsulating curcumin in the 3D fibrous network of oleogel. More interestingly, glycolipid in its native form demoed potential in disassembling methicillin-resistant Staphylococcus aureus , methicillin-susceptible Staphylococcus aureus , and Pseudomonas aeruginosa biofilms . Both oleogel and composite gel enhanced the wound skin repair in diabetic induced Wistar rats by promoting collagen synthesis, controlling free radical generation and further regulating tissue remodeling phases. Altogether, the reported supramolecular self-assembled anesthetic glycolipid could be potentially used for diabetic skin wound repair and to treat bacterial biofilm related infections.
doi_str_mv 10.1038/s41598-020-73708-7
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subjects 631/326/22
631/326/41
631/326/46
639/301
639/638
639/925
692/4017
692/700
Anesthetics - pharmacology
Animals
Biofilms
Biofilms - drug effects
Biofilms - growth & development
Biomaterials
Collagen
Curcumin
Diabetes
Diabetes mellitus
Diabetes Mellitus, Experimental - physiopathology
Drug resistance
Female
Glycolipids - pharmacology
Humanities and Social Sciences
Hydrophobicity
Methicillin
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Microbial contamination
multidisciplinary
Organic Chemicals - administration & dosage
Organic Chemicals - pharmacology
Paraffin
Polymers
Rats
Rats, Wistar
Science
Science (multidisciplinary)
Self-assembly
Skin
Skin Diseases - drug therapy
Skin Diseases - etiology
Skin Diseases - pathology
Staphylococcal Infections - complications
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus infections
Wound healing
Wound Healing - drug effects
Wound Infection - drug therapy
Wound Infection - etiology
Wound Infection - pathology
title An injectable self-healing anesthetic glycolipid-based oleogel with antibiofilm and diabetic wound skin repair properties
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