Diagnostic ability of maximum blink interval together with Japanese version of Ocular Surface Disease Index score for dry eye disease
Various symptoms of the dry eye disease (DED) interfere with the quality of life and reduce work productivity. Therefore, screening, prevention, and treatment of DED are important. We aimed to investigate the potential diagnostic ability of the maximum blink interval (MBI) (the length of time partic...
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| Veröffentlicht in: | Scientific reports 2020-10, Vol.10 (1), p.18106-18106, Article 18106 |
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| creator | Hirosawa, Kunihiko Inomata, Takenori Sung, Jaemyoung Nakamura, Masahiro Okumura, Yuichi Midorikawa-Inomata, Akie Miura, Maria Fujio, Kenta Akasaki, Yasutsugu Fujimoto, Keiichi Zhu, Jun Eguchi, Atsuko Nagino, Ken Kuwahara, Mizu Shokirova, Hurramhon Yanagawa, Ai Murakami, Akira |
| description | Various symptoms of the dry eye disease (DED) interfere with the quality of life and reduce work productivity. Therefore, screening, prevention, and treatment of DED are important. We aimed to investigate the potential diagnostic ability of the maximum blink interval (MBI) (the length of time participants could keep their eyes open) with disease-specific questionnaire for DED. This cross-sectional study included 365 patients (252 with DED and 113 without DED) recruited between September 2017 and December 2019. Discriminant validity was assessed by comparing the non-DED and DED groups based on the MBI with a Japanese version of the Ocular Surface Disease Index (J-OSDI) and tear film breakup time (TFBUT) with J-OSDI classifications. The MBI with J-OSDI showed good discriminant validity by known-group comparisons. The positive and predictive values of MBI with J-OSDI were 96.0% (190/198 individuals) and 37.1% (62/167 individuals), respectively. The area under the receiver operating characteristic curve (AUC) of MBI with J-OSDI was 0.938 (95% confidence interval 0.904–0.971), the sensitivity was 75.4% (190/252 individuals), and the specificity was 92.9% (105/113 individuals), which are similar to the diagnostic ability of TFBUT with J-OSDI (AUC 0.954). In conclusion, MBI with J-OSDI may be a simple, non-invasive screening test for DED. |
| doi_str_mv | 10.1038/s41598-020-75193-4 |
| format | Article |
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Therefore, screening, prevention, and treatment of DED are important. We aimed to investigate the potential diagnostic ability of the maximum blink interval (MBI) (the length of time participants could keep their eyes open) with disease-specific questionnaire for DED. This cross-sectional study included 365 patients (252 with DED and 113 without DED) recruited between September 2017 and December 2019. Discriminant validity was assessed by comparing the non-DED and DED groups based on the MBI with a Japanese version of the Ocular Surface Disease Index (J-OSDI) and tear film breakup time (TFBUT) with J-OSDI classifications. The MBI with J-OSDI showed good discriminant validity by known-group comparisons. The positive and predictive values of MBI with J-OSDI were 96.0% (190/198 individuals) and 37.1% (62/167 individuals), respectively. The area under the receiver operating characteristic curve (AUC) of MBI with J-OSDI was 0.938 (95% confidence interval 0.904–0.971), the sensitivity was 75.4% (190/252 individuals), and the specificity was 92.9% (105/113 individuals), which are similar to the diagnostic ability of TFBUT with J-OSDI (AUC 0.954). In conclusion, MBI with J-OSDI may be a simple, non-invasive screening test for DED.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-75193-4</identifier><identifier>PMID: 33093551</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/53/2421 ; 692/699/3161/3163 ; 692/699/3161/3167 ; Blinking - physiology ; Conjunctival Diseases - physiopathology ; Corneal Diseases - physiopathology ; Cross-Sectional Studies ; Dry Eye Syndromes - diagnosis ; Eye ; Eye diseases ; Female ; Follow-Up Studies ; Humanities and Social Sciences ; Humans ; Male ; Mass Screening ; Middle Aged ; multidisciplinary ; Osmolar Concentration ; Prognosis ; Quality of Life ; ROC Curve ; Science ; Science (multidisciplinary) ; Surveys and Questionnaires</subject><ispartof>Scientific reports, 2020-10, Vol.10 (1), p.18106-18106, Article 18106</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-a8d426a36d5fef4ffca7e19c12695cdca1f0cfcb28158188142a2d89de3a83e23</citedby><cites>FETCH-LOGICAL-c522t-a8d426a36d5fef4ffca7e19c12695cdca1f0cfcb28158188142a2d89de3a83e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582156/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582156/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,41119,42188,51575,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33093551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirosawa, Kunihiko</creatorcontrib><creatorcontrib>Inomata, Takenori</creatorcontrib><creatorcontrib>Sung, Jaemyoung</creatorcontrib><creatorcontrib>Nakamura, Masahiro</creatorcontrib><creatorcontrib>Okumura, Yuichi</creatorcontrib><creatorcontrib>Midorikawa-Inomata, Akie</creatorcontrib><creatorcontrib>Miura, Maria</creatorcontrib><creatorcontrib>Fujio, Kenta</creatorcontrib><creatorcontrib>Akasaki, Yasutsugu</creatorcontrib><creatorcontrib>Fujimoto, Keiichi</creatorcontrib><creatorcontrib>Zhu, Jun</creatorcontrib><creatorcontrib>Eguchi, Atsuko</creatorcontrib><creatorcontrib>Nagino, Ken</creatorcontrib><creatorcontrib>Kuwahara, Mizu</creatorcontrib><creatorcontrib>Shokirova, Hurramhon</creatorcontrib><creatorcontrib>Yanagawa, Ai</creatorcontrib><creatorcontrib>Murakami, Akira</creatorcontrib><title>Diagnostic ability of maximum blink interval together with Japanese version of Ocular Surface Disease Index score for dry eye disease</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Various symptoms of the dry eye disease (DED) interfere with the quality of life and reduce work productivity. Therefore, screening, prevention, and treatment of DED are important. We aimed to investigate the potential diagnostic ability of the maximum blink interval (MBI) (the length of time participants could keep their eyes open) with disease-specific questionnaire for DED. This cross-sectional study included 365 patients (252 with DED and 113 without DED) recruited between September 2017 and December 2019. Discriminant validity was assessed by comparing the non-DED and DED groups based on the MBI with a Japanese version of the Ocular Surface Disease Index (J-OSDI) and tear film breakup time (TFBUT) with J-OSDI classifications. The MBI with J-OSDI showed good discriminant validity by known-group comparisons. The positive and predictive values of MBI with J-OSDI were 96.0% (190/198 individuals) and 37.1% (62/167 individuals), respectively. The area under the receiver operating characteristic curve (AUC) of MBI with J-OSDI was 0.938 (95% confidence interval 0.904–0.971), the sensitivity was 75.4% (190/252 individuals), and the specificity was 92.9% (105/113 individuals), which are similar to the diagnostic ability of TFBUT with J-OSDI (AUC 0.954). In conclusion, MBI with J-OSDI may be a simple, non-invasive screening test for DED.</description><subject>692/53/2421</subject><subject>692/699/3161/3163</subject><subject>692/699/3161/3167</subject><subject>Blinking - physiology</subject><subject>Conjunctival Diseases - physiopathology</subject><subject>Corneal Diseases - physiopathology</subject><subject>Cross-Sectional Studies</subject><subject>Dry Eye Syndromes - diagnosis</subject><subject>Eye</subject><subject>Eye diseases</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Mass Screening</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Osmolar Concentration</subject><subject>Prognosis</subject><subject>Quality of Life</subject><subject>ROC Curve</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Surveys and Questionnaires</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1u1DAUhS0EolXpC7BAltiwCfh3xtkgoRZKUaUugLV1x7mecUnswU6GzgPw3nVJKYUF3tjS-c6xrw8hzzl7zZk0b4riujUNE6xZat7KRj0ih4Ip3QgpxOMH5wNyXMoVq0uLVvH2KTmQkrVSa35Ifp4GWMdUxuAorEIfxj1Nng5wHYZpoKs-xG80xBHzDno6pjWOG8z0Rxg39BNsIWJBusNcQoq3xks39ZDp5yl7cEhPQ0GoxHns8JoWlzJSnzLt8p7iHmk368_IEw99weO7_Yh8_fD-y8nH5uLy7Pzk3UXjtBBjA6ZTYgFy0WmPXnnvYIm8dVwsWu06B9wz591KGK4NN4YrAaIzbYcSjEQhj8jbOXc7rQbsHMYxQ2-3OQyQ9zZBsH8rMWzsOu3sUhvB9aIGvLoLyOn7hGW0QygO-75-RJqKFUqrWo-SrKIv_0Gv0pRjHa9SS66F4oZXSsyUy6mUjP7-MZzZ26LtXLStRdtfRVtVTS8ejnFv-V1rBeQMlCrFNeY_d_8n9gbtZbaD</recordid><startdate>20201022</startdate><enddate>20201022</enddate><creator>Hirosawa, Kunihiko</creator><creator>Inomata, Takenori</creator><creator>Sung, Jaemyoung</creator><creator>Nakamura, Masahiro</creator><creator>Okumura, Yuichi</creator><creator>Midorikawa-Inomata, Akie</creator><creator>Miura, Maria</creator><creator>Fujio, Kenta</creator><creator>Akasaki, Yasutsugu</creator><creator>Fujimoto, Keiichi</creator><creator>Zhu, Jun</creator><creator>Eguchi, Atsuko</creator><creator>Nagino, Ken</creator><creator>Kuwahara, Mizu</creator><creator>Shokirova, Hurramhon</creator><creator>Yanagawa, Ai</creator><creator>Murakami, Akira</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201022</creationdate><title>Diagnostic ability of maximum blink interval together with Japanese version of Ocular Surface Disease Index score for dry eye disease</title><author>Hirosawa, Kunihiko ; Inomata, Takenori ; Sung, Jaemyoung ; Nakamura, Masahiro ; Okumura, Yuichi ; Midorikawa-Inomata, Akie ; Miura, Maria ; Fujio, Kenta ; Akasaki, Yasutsugu ; Fujimoto, Keiichi ; Zhu, Jun ; Eguchi, Atsuko ; Nagino, Ken ; Kuwahara, Mizu ; Shokirova, Hurramhon ; Yanagawa, Ai ; Murakami, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-a8d426a36d5fef4ffca7e19c12695cdca1f0cfcb28158188142a2d89de3a83e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/53/2421</topic><topic>692/699/3161/3163</topic><topic>692/699/3161/3167</topic><topic>Blinking - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirosawa, Kunihiko</au><au>Inomata, Takenori</au><au>Sung, Jaemyoung</au><au>Nakamura, Masahiro</au><au>Okumura, Yuichi</au><au>Midorikawa-Inomata, Akie</au><au>Miura, Maria</au><au>Fujio, Kenta</au><au>Akasaki, Yasutsugu</au><au>Fujimoto, Keiichi</au><au>Zhu, Jun</au><au>Eguchi, Atsuko</au><au>Nagino, Ken</au><au>Kuwahara, Mizu</au><au>Shokirova, Hurramhon</au><au>Yanagawa, Ai</au><au>Murakami, Akira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic ability of maximum blink interval together with Japanese version of Ocular Surface Disease Index score for dry eye disease</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-10-22</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>18106</spage><epage>18106</epage><pages>18106-18106</pages><artnum>18106</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Various symptoms of the dry eye disease (DED) interfere with the quality of life and reduce work productivity. Therefore, screening, prevention, and treatment of DED are important. We aimed to investigate the potential diagnostic ability of the maximum blink interval (MBI) (the length of time participants could keep their eyes open) with disease-specific questionnaire for DED. This cross-sectional study included 365 patients (252 with DED and 113 without DED) recruited between September 2017 and December 2019. Discriminant validity was assessed by comparing the non-DED and DED groups based on the MBI with a Japanese version of the Ocular Surface Disease Index (J-OSDI) and tear film breakup time (TFBUT) with J-OSDI classifications. The MBI with J-OSDI showed good discriminant validity by known-group comparisons. The positive and predictive values of MBI with J-OSDI were 96.0% (190/198 individuals) and 37.1% (62/167 individuals), respectively. The area under the receiver operating characteristic curve (AUC) of MBI with J-OSDI was 0.938 (95% confidence interval 0.904–0.971), the sensitivity was 75.4% (190/252 individuals), and the specificity was 92.9% (105/113 individuals), which are similar to the diagnostic ability of TFBUT with J-OSDI (AUC 0.954). In conclusion, MBI with J-OSDI may be a simple, non-invasive screening test for DED.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33093551</pmid><doi>10.1038/s41598-020-75193-4</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/53/2421 692/699/3161/3163 692/699/3161/3167 Blinking - physiology Conjunctival Diseases - physiopathology Corneal Diseases - physiopathology Cross-Sectional Studies Dry Eye Syndromes - diagnosis Eye Eye diseases Female Follow-Up Studies Humanities and Social Sciences Humans Male Mass Screening Middle Aged multidisciplinary Osmolar Concentration Prognosis Quality of Life ROC Curve Science Science (multidisciplinary) Surveys and Questionnaires |
| title | Diagnostic ability of maximum blink interval together with Japanese version of Ocular Surface Disease Index score for dry eye disease |
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