TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer

Breast cancer is one of the most common female malignant cancers. Biorhythm disorder largely increases the risk of breast cancer. We aimed to investigate the biological functions and molecular mechanisms of circadian gene TIMELESS circadian regulator (TIM) in estrogen receptor (ER)-positive breast c...

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Veröffentlicht in:	Cell death & disease 2020-10, Vol.11 (10), p.892-892, Article 892
Hauptverfasser:	Zhang, Shan, Huang, Peiqi, Dai, Huijuan, Li, Qing, Hu, Lipeng, Peng, Jing, Jiang, Shuheng, Xu, Yaqian, Wu, Ziping, Nie, Huizhen, Zhang, Zhigang, Yin, Wenjin, Zhang, Xueli, Lu, Jinsong
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 13/1 13/51 13/89 14/19 38 631/67/1347 631/67/2327 96/109 Alkaline Ceramidase - physiology Animals Antibodies Biochemistry Biomedical and Life Sciences Biopsy Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Biology Cell Culture Cell Cycle Proteins - physiology Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Ceramidase Circadian rhythms Estrogen receptors Female Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans Immunology Intracellular Signaling Peptides and Proteins - physiology Life Sciences Lipid metabolism Lysophospholipids - physiology Metabolism Mice Mice, Nude Mitochondria Mitochondria - drug effects Molecular modelling Respiration Sp1 protein Sp1 Transcription Factor - physiology Sphingolipids - metabolism Sphingosine - analogs & derivatives Sphingosine - physiology Therapeutic applications Xenograft Model Antitumor Assays
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