Ser and Thr acceptor preferences of the GalNAc-Ts vary among isoenzymes to modulate mucin-type O-glycosylation

Abstract A family of polypeptide GalNAc-transferases (GalNAc-Ts) initiates mucin-type O-glycosylation, transferring GalNAc onto hydroxyl groups of Ser and Thr residues of target substrates. The 20 GalNAc-T isoenzymes in humans are classified into nine subfamilies according to sequence similarity. Ga...

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Veröffentlicht in:	Glycobiology (Oxford) 2020-10, Vol.30 (11), p.910-922
Hauptverfasser:	Daniel, Earnest James Paul, las Rivas, Matilde, Lira-Navarrete, Erandi, García-García, Ana, Hurtado-Guerrero, Ramon, Clausen, Henrik, Gerken, Thomas A
Format:	Artikel
Sprache:	eng
Schlagworte:	Glycan Synthesis Glycosylation Humans Isoenzymes - chemistry Isoenzymes - metabolism Mucins - chemistry Mucins - metabolism N-Acetylgalactosaminyltransferases - chemistry N-Acetylgalactosaminyltransferases - metabolism Polypeptide N-acetylgalactosaminyltransferase Serine - chemistry Serine - metabolism Threonine - chemistry Threonine - metabolism
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