Overexpression of Phospho-eIF4E Is Associated with Survival through AKT Pathway in Non–Small Cell Lung Cancer

Purpose: The eukaryotic translation initiation factor complex 4E (eIF4E) is downstream in the mammalian target of rapamycin (mTOR) pathway. This study explored expression of eIF4E and its relationship with the PTEN/AKT and RAS/MEK/ERK pathways in non–small cell lung carcinoma (NSCLC). Experimental D...

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Veröffentlicht in:	Clinical cancer research 2010-01, Vol.16 (1), p.240-248
Hauptverfasser:	Yoshizawa, Akihiko, Fukuoka, Junya, Shimizu, Shigeki, Shilo, Konstantin, Franks, Teri J, Hewitt, Stephen M, Fujii, Takeshi, Cordon-Cardo, Carlos, Jen, Jin, Travis, William D
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT pathway Antineoplastic agents Biological and medical sciences Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality eIF4E Erk1/2 Eukaryotic Initiation Factor-4E - metabolism Female Humans Lung Neoplasms - metabolism Lung Neoplasms - mortality Male Medical sciences Mitogen-Activated Protein Kinase 3 - metabolism non–small cell lung cancer Pharmacology. Drug treatments Phosphorylation Pneumology Prognosis Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - metabolism Signal Transduction Tissue Array Analysis Tumors of the respiratory system and mediastinum
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