Suboptimal management of hypertriglyceridemia in the outpatient setting is associated with the recurrent pancreatitis: A retrospective cohort study
Hyperlipemia is a well-established etiology of acute pancreatitis. However, few data are available in the medical literature about the management of triglyceride levels in the outpatient setting in patients with hypertriglyceridemic acute pancreatitis (HTG-AP). We evaluated the blood triglyceride le...
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| Veröffentlicht in: | Medicine (Baltimore) 2020-10, Vol.99 (43), p.e22887-e22887 |
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| creator | Yan, Ping Zhao, Hong-Xian Chen, Xia |
| description | Hyperlipemia is a well-established etiology of acute pancreatitis. However, few data are available in the medical literature about the management of triglyceride levels in the outpatient setting in patients with hypertriglyceridemic acute pancreatitis (HTG-AP). We evaluated the blood triglyceride levels and followed the triglyceride management of patients with HTG-AP.This retrospective study enrolled patients with HTG-AP from January 2013 to March 2019 in the Affiliated Hospital of Southwest Medical of University. By reviewing the hospitalization records and the follow-up data, the clinical features, blood triglyceride levels, use of lipid-lowering medications and rate of blood triglyceride levels monitoring after hospital discharge were analyzed.A total of 133 patients (46 women, 87 men; median age at presentation 37.4 years) diagnosed with HTG-AP were enrolled in the study. Thirty-two patients (24.1%) presented with recurrent acute pancreatitis (RAP). Patients who had RAP were younger and had higher blood triglyceride levels than those with a single attack (P |
| doi_str_mv | 10.1097/MD.0000000000022887 |
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However, few data are available in the medical literature about the management of triglyceride levels in the outpatient setting in patients with hypertriglyceridemic acute pancreatitis (HTG-AP). We evaluated the blood triglyceride levels and followed the triglyceride management of patients with HTG-AP.This retrospective study enrolled patients with HTG-AP from January 2013 to March 2019 in the Affiliated Hospital of Southwest Medical of University. By reviewing the hospitalization records and the follow-up data, the clinical features, blood triglyceride levels, use of lipid-lowering medications and rate of blood triglyceride levels monitoring after hospital discharge were analyzed.A total of 133 patients (46 women, 87 men; median age at presentation 37.4 years) diagnosed with HTG-AP were enrolled in the study. Thirty-two patients (24.1%) presented with recurrent acute pancreatitis (RAP). Patients who had RAP were younger and had higher blood triglyceride levels than those with a single attack (P < .05). No difference in serum amylase levels, hospitalization duration or mortality rate were observed between non-recurrent acute pancreatitis and RAP patients. Lipid monitoring was only observed in 12.8% of patients and 10 patients (7.5%) took medications to control their blood triglyceride levels after hospital discharge. The follow-up of triglyceride levels in the outpatient setting were higher in RAP patients than in patients with non-recurrent acute pancreatitis (P < .05). Among the patients who measured their triglyceride levels after discharge, 83.3% of patients with RAP had at least 1 follow-up triglyceride level that was higher than 500 mg/dL, while no patients had an HTG-AP attack with a triglyceride level higher than 500 mg/dL.Triglyceride levels after hospital discharge higher than 500 mg/dL may be associated with an increased risk of relapse of clinical acute pancreatitis events. Inappropriate management for triglyceride control in the outpatient setting may be associated with an increased risk of relapse of clinical HTG-AP events.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000022887</identifier><identifier>PMID: 33120833</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Adult ; Amylases - blood ; Case-Control Studies ; China - epidemiology ; Female ; Follow-Up Studies ; Hospitalization - statistics & numerical data ; Humans ; Hyperlipidemias - complications ; Hypertriglyceridemia - drug therapy ; Hypertriglyceridemia - epidemiology ; Hypolipidemic Agents - therapeutic use ; Male ; Middle Aged ; Mortality ; Observational Study ; Outpatients - statistics & numerical data ; Pancreatitis - diagnosis ; Pancreatitis - etiology ; Patient Discharge ; Recurrence ; Retrospective Studies ; Triglycerides - blood</subject><ispartof>Medicine (Baltimore), 2020-10, Vol.99 (43), p.e22887-e22887</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3559-5091efca299eae6ce5a19df7334f94858bcc50f2b5636d9a264a5b950ee12a6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581036/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581036/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33120833$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Ping</creatorcontrib><creatorcontrib>Zhao, Hong-Xian</creatorcontrib><creatorcontrib>Chen, Xia</creatorcontrib><title>Suboptimal management of hypertriglyceridemia in the outpatient setting is associated with the recurrent pancreatitis: A retrospective cohort study</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Hyperlipemia is a well-established etiology of acute pancreatitis. However, few data are available in the medical literature about the management of triglyceride levels in the outpatient setting in patients with hypertriglyceridemic acute pancreatitis (HTG-AP). We evaluated the blood triglyceride levels and followed the triglyceride management of patients with HTG-AP.This retrospective study enrolled patients with HTG-AP from January 2013 to March 2019 in the Affiliated Hospital of Southwest Medical of University. By reviewing the hospitalization records and the follow-up data, the clinical features, blood triglyceride levels, use of lipid-lowering medications and rate of blood triglyceride levels monitoring after hospital discharge were analyzed.A total of 133 patients (46 women, 87 men; median age at presentation 37.4 years) diagnosed with HTG-AP were enrolled in the study. Thirty-two patients (24.1%) presented with recurrent acute pancreatitis (RAP). Patients who had RAP were younger and had higher blood triglyceride levels than those with a single attack (P < .05). No difference in serum amylase levels, hospitalization duration or mortality rate were observed between non-recurrent acute pancreatitis and RAP patients. Lipid monitoring was only observed in 12.8% of patients and 10 patients (7.5%) took medications to control their blood triglyceride levels after hospital discharge. The follow-up of triglyceride levels in the outpatient setting were higher in RAP patients than in patients with non-recurrent acute pancreatitis (P < .05). Among the patients who measured their triglyceride levels after discharge, 83.3% of patients with RAP had at least 1 follow-up triglyceride level that was higher than 500 mg/dL, while no patients had an HTG-AP attack with a triglyceride level higher than 500 mg/dL.Triglyceride levels after hospital discharge higher than 500 mg/dL may be associated with an increased risk of relapse of clinical acute pancreatitis events. Inappropriate management for triglyceride control in the outpatient setting may be associated with an increased risk of relapse of clinical HTG-AP events.</description><subject>Adult</subject><subject>Amylases - blood</subject><subject>Case-Control Studies</subject><subject>China - epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Hyperlipidemias - complications</subject><subject>Hypertriglyceridemia - drug therapy</subject><subject>Hypertriglyceridemia - epidemiology</subject><subject>Hypolipidemic Agents - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Observational Study</subject><subject>Outpatients - statistics & numerical data</subject><subject>Pancreatitis - diagnosis</subject><subject>Pancreatitis - etiology</subject><subject>Patient Discharge</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><subject>Triglycerides - blood</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkstu1DAUhi0EokPhCZCQl2xSfImTmAVS1XKTWrEA1taJczIxJHGwnY7mOXhhPJ1SLt5Y8vn-_xz7NyHPOTvjTNevri_P2J8lRNPUD8iGK1kVSlflQ7LJp6qodV2ekCcxfmOMy1qUj8mJlFywRsoN-fl5bf2S3AQjnWCGLU44J-p7OuwXDCm47bi3GFyHkwPqZpoGpH5NCyR3ICOm5OYtdZFCjN46SNjRnUvDLRnQriEcwAVmGzCrkouv6XmupODjgja5G6TWDz5kt7R2-6fkUQ9jxGd3-yn5-u7tl4sPxdWn9x8vzq8KK5XShWKaY29BaI2AlUUFXHd9LWXZ67JRTWutYr1oVSWrToOoSlCtVgyRC6h6eUreHH2XtZ2ws3nKAKNZQn6NsDcenPm3MrvBbP2NqVXDmayywcs7g-B_rBiTmVy0OI4wo1-jEaWqSp771hmVR9TmS8eA_X0bzswhTnN9af6PM6te_D3hveZ3fhkoj8DOjwlD_D6uOwxmQBjTcOunai0KwQTjTEhW5D_AtPwF_5OwWw</recordid><startdate>20201023</startdate><enddate>20201023</enddate><creator>Yan, Ping</creator><creator>Zhao, Hong-Xian</creator><creator>Chen, Xia</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201023</creationdate><title>Suboptimal management of hypertriglyceridemia in the outpatient setting is associated with the recurrent pancreatitis: A retrospective cohort study</title><author>Yan, Ping ; Zhao, Hong-Xian ; Chen, Xia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3559-5091efca299eae6ce5a19df7334f94858bcc50f2b5636d9a264a5b950ee12a6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Amylases - blood</topic><topic>Case-Control Studies</topic><topic>China - epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Hyperlipidemias - complications</topic><topic>Hypertriglyceridemia - drug therapy</topic><topic>Hypertriglyceridemia - epidemiology</topic><topic>Hypolipidemic Agents - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Observational Study</topic><topic>Outpatients - statistics & numerical data</topic><topic>Pancreatitis - diagnosis</topic><topic>Pancreatitis - etiology</topic><topic>Patient Discharge</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Ping</creatorcontrib><creatorcontrib>Zhao, Hong-Xian</creatorcontrib><creatorcontrib>Chen, Xia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Ping</au><au>Zhao, Hong-Xian</au><au>Chen, Xia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suboptimal management of hypertriglyceridemia in the outpatient setting is associated with the recurrent pancreatitis: A retrospective cohort study</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2020-10-23</date><risdate>2020</risdate><volume>99</volume><issue>43</issue><spage>e22887</spage><epage>e22887</epage><pages>e22887-e22887</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Hyperlipemia is a well-established etiology of acute pancreatitis. However, few data are available in the medical literature about the management of triglyceride levels in the outpatient setting in patients with hypertriglyceridemic acute pancreatitis (HTG-AP). We evaluated the blood triglyceride levels and followed the triglyceride management of patients with HTG-AP.This retrospective study enrolled patients with HTG-AP from January 2013 to March 2019 in the Affiliated Hospital of Southwest Medical of University. By reviewing the hospitalization records and the follow-up data, the clinical features, blood triglyceride levels, use of lipid-lowering medications and rate of blood triglyceride levels monitoring after hospital discharge were analyzed.A total of 133 patients (46 women, 87 men; median age at presentation 37.4 years) diagnosed with HTG-AP were enrolled in the study. Thirty-two patients (24.1%) presented with recurrent acute pancreatitis (RAP). Patients who had RAP were younger and had higher blood triglyceride levels than those with a single attack (P < .05). No difference in serum amylase levels, hospitalization duration or mortality rate were observed between non-recurrent acute pancreatitis and RAP patients. Lipid monitoring was only observed in 12.8% of patients and 10 patients (7.5%) took medications to control their blood triglyceride levels after hospital discharge. The follow-up of triglyceride levels in the outpatient setting were higher in RAP patients than in patients with non-recurrent acute pancreatitis (P < .05). Among the patients who measured their triglyceride levels after discharge, 83.3% of patients with RAP had at least 1 follow-up triglyceride level that was higher than 500 mg/dL, while no patients had an HTG-AP attack with a triglyceride level higher than 500 mg/dL.Triglyceride levels after hospital discharge higher than 500 mg/dL may be associated with an increased risk of relapse of clinical acute pancreatitis events. Inappropriate management for triglyceride control in the outpatient setting may be associated with an increased risk of relapse of clinical HTG-AP events.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>33120833</pmid><doi>10.1097/MD.0000000000022887</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Amylases - blood Case-Control Studies China - epidemiology Female Follow-Up Studies Hospitalization - statistics & numerical data Humans Hyperlipidemias - complications Hypertriglyceridemia - drug therapy Hypertriglyceridemia - epidemiology Hypolipidemic Agents - therapeutic use Male Middle Aged Mortality Observational Study Outpatients - statistics & numerical data Pancreatitis - diagnosis Pancreatitis - etiology Patient Discharge Recurrence Retrospective Studies Triglycerides - blood |
| title | Suboptimal management of hypertriglyceridemia in the outpatient setting is associated with the recurrent pancreatitis: A retrospective cohort study |
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