Aryl-fluorosulfate-based Lysine Covalent pan-Inhibitors of Apoptosis Proteins (IAP) Antagonists with Cellular Efficacy

We have recently investigated the reactivity of aryl-fluorosulfates as warheads to form covalent adducts with Lys, Tyr, and His residues. However, the rate of reaction of aryl-fluorosulfates seemed relatively slow, putting into question their effectiveness to form covalent adducts in cell. Unlike th...

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Veröffentlicht in:	Journal of medicinal chemistry 2019-10, Vol.62 (20), p.9188-9200
Hauptverfasser:	Baggio, Carlo, Udompholkul, Parima, Gambini, Luca, Salem, Ahmed F., Jossart, Jennifer, Perry, J. Jefferson P., Pellecchia, Maurizio
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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