LIGHT aggravates sepsis‐associated acute kidney injury via TLR4‐MyD88‐NF‐κB pathway

Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical critical care syndrome. It has received increasing attention due to its high morbidity and mortality; however, its pathophysiological mechanisms remain elusive. LIGHT, the 14th member of the tumour necrosis factor (TNF) superfamily...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-10, Vol.24 (20), p.11936-11948
Hauptverfasser:	Zhong, Yu, Wu, Shun, Yang, Yan, Li, Gui‐qing, Meng, Li, Zheng, Quan‐you, Li, You, Xu, Gui‐lian, Zhang, Ke‐qin, Peng, Kan‐fu
Format:	Artikel
Sprache:	eng
Schlagworte:	acute kidney injury Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Animals Apoptosis Cell injury Cell Line Down-Regulation Fc receptors Gene expression Humans Immunoregulation Inflammation Inflammation - pathology Inflammation Mediators - metabolism Kidneys Laboratory animals LIGHT Lipopolysaccharides Metastases Mice, Knockout Models, Biological Morbidity MyD88 protein Myeloid Differentiation Factor 88 - metabolism NF-kappa B - metabolism NF‐κB Original Pathophysiology Proteins Reagents Renal function Sepsis Sepsis - metabolism Signal Transduction Survival Analysis TLR4 TLR4 protein Toll-Like Receptor 4 - metabolism Toll-like receptors Tumor necrosis factor Tumor Necrosis Factor Ligand Superfamily Member 14 - deficiency Tumor Necrosis Factor Ligand Superfamily Member 14 - metabolism Tumors
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