Evaluation of New Octacalcium Phosphate-Coated Xenograft in Rats Calvarial Defect Model on Bone Regeneration

Bone graft material is essential for satisfactory and sufficient bone growth which leads to a successful implant procedure. It is classified into autogenous bone, allobone, xenobone and alloplastic materials. Among them, it has been reported that heterogeneous bone graft material has a porous micros...

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Veröffentlicht in:Materials 2020-10, Vol.13 (19), p.4391, Article 4391
Hauptverfasser: Jung, Yoona, Kim, Won-Hyeon, Lee, Sung-Ho, Ju, Kyung Won, Jang, Eun-Hee, Kim, Sung-O, Kim, Bongju, Lee, Jong-Ho
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container_issue 19
container_start_page 4391
container_title Materials
container_volume 13
creator Jung, Yoona
Kim, Won-Hyeon
Lee, Sung-Ho
Ju, Kyung Won
Jang, Eun-Hee
Kim, Sung-O
Kim, Bongju
Lee, Jong-Ho
description Bone graft material is essential for satisfactory and sufficient bone growth which leads to a successful implant procedure. It is classified into autogenous bone, allobone, xenobone and alloplastic materials. Among them, it has been reported that heterogeneous bone graft material has a porous microstructure that increases blood vessels and bone formation, and shows faster bone formation than other types of bone graft materials. We observed new bone tissue formation and bone remodeling using Ti-oss (R) (Chiyewon Co., Ltd., Guri, Korea), a heterologous bone graft material. Using a Sprague-Dawley rat calvarial defect model to evaluate the bone healing e ffect of biomaterials, the efficacy of the newly developed xenograft Ti-oss (R) and Bio-Oss (R) (Geistilch Pharma AG, Wolhusen, Switzerland). The experimental animals were sacrificed at 8 and 12 weeks after surgery for each group and the experimental site was extracted. The average new bone area for the Ti-oss (R) experimental group at 8 weeks was 17.6%. The remaining graft material was 22.7% for the experimental group. The average new bone area for the Ti-oss (R) group was 24.3% at 12 weeks. The remaining graft material was 22.8% for the experimental group. It can be evaluated that the new bone-forming ability of Ti-oss (R) with octacalcium phosphate (OCP) has the bone-forming ability corresponding to the conventional products.
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The average new bone area for the Ti-oss (R) group was 24.3% at 12 weeks. The remaining graft material was 22.8% for the experimental group. 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The average new bone area for the Ti-oss (R) group was 24.3% at 12 weeks. The remaining graft material was 22.8% for the experimental group. It can be evaluated that the new bone-forming ability of Ti-oss (R) with octacalcium phosphate (OCP) has the bone-forming ability corresponding to the conventional products.</abstract><cop>BASEL</cop><pub>Mdpi</pub><pmid>33019762</pmid><doi>10.3390/ma13194391</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9742-7945</orcidid><orcidid>https://orcid.org/0000-0003-3553-761X</orcidid><orcidid>https://orcid.org/0000-0002-8843-545X</orcidid><oa>free_for_read</oa></addata></record>
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subjects Animals
Biocompatibility
Biodegradable materials
Biomedical materials
Blood vessels
Bones
Calcium phosphates
Chemistry
Chemistry, Physical
Connective tissue
Evaluation
Grafting
Grafts
Materials Science
Materials Science, Multidisciplinary
Metallurgy & Metallurgical Engineering
Pharmaceuticals
Physical Sciences
Physics
Physics, Applied
Physics, Condensed Matter
Pore size
Porous materials
Regeneration (physiology)
Science & Technology
Skin & tissue grafts
Substitute bone
Supply & demand
Surgical implants
Technology
Titanium alloys
Transplants & implants
Xenotransplantation
title Evaluation of New Octacalcium Phosphate-Coated Xenograft in Rats Calvarial Defect Model on Bone Regeneration
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