Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia

The suppression of energy metabolism is one of cornerstones of cardiac dysfunction in sepsis/endotoxaemia. To investigate the role of fatty acid oxidation (FAO) in the progression of inflammation‐induced cardiac dysfunction, we compared the effects of FAO‐targeting compounds on mitochondrial and car...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-10, Vol.24 (20), p.11903-11911
Hauptverfasser:	Makrecka‐Kuka, Marina, Korzh, Stanislava, Videja, Melita, Vilskersts, Reinis, Sevostjanovs, Eduards, Zharkova‐Malkova, Olga, Arsenyan, Pavel, Kuka, Janis, Dambrova, Maija, Liepinsh, Edgars
Format:	Artikel
Sprache:	eng
Schlagworte:	acylcarnitine AMP Animals Biomarkers - blood Blood Glucose - metabolism Body Temperature Cardiac function Carnitine O-Palmitoyltransferase - antagonists & inhibitors Carnitine O-Palmitoyltransferase - metabolism Carnitine palmitoyltransferase Disease Progression endotoxaemia Endotoxemia - blood Endotoxemia - enzymology Endotoxemia - physiopathology Energy Energy Metabolism fatty acid oxidation Fatty acids Fatty Acids - metabolism Fatty-acid synthase Female Food Gene expression Glucose Heart Heart - physiopathology Inflammation Inflammation - blood Inflammation - complications Inflammation - enzymology Inflammation - pathology Intermediates Kinases Lipopolysaccharides Mechanical properties Metabolism Mice Mitochondria Mitochondria, Heart - metabolism Original Oxidation Palmitoyltransferase Phosphorylation Protein kinase Pyruvic acid Respiration Sepsis
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