Circles of Life: linking metabolic and epigenetic cycles to immunity
Summary Metabolites are the essential substrates for epigenetic modification enzymes to write or erase the epigenetic blueprint in cells. Hence, the availability of nutrients and activity of metabolic pathways strongly influence the enzymatic function. Recent studies have shed light on the choreogra...
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| Veröffentlicht in: | Immunology 2020-11, Vol.161 (3), p.165-174 |
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| container_title | Immunology |
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| creator | Lio, Chan‐Wang Jerry Huang, Stanley Ching‐Cheng |
| description | Summary
Metabolites are the essential substrates for epigenetic modification enzymes to write or erase the epigenetic blueprint in cells. Hence, the availability of nutrients and activity of metabolic pathways strongly influence the enzymatic function. Recent studies have shed light on the choreography between metabolome and epigenome in the control of immune cell differentiation and function, with a major focus on histone modifications. Yet, despite its importance in gene regulation, DNA methylation and its relationship with metabolism is relatively unclear. In this review, we will describe how the metabolic flux can influence epigenetic networks in innate and adaptive immune cells, with a focus on the DNA methylation cycle and the metabolites S‐adenosylmethionine and α‐ketoglutarate. Future directions will be discussed for this rapidly emerging field.
The interconnected metabolic and DNA methylation cycles. |
| doi_str_mv | 10.1111/imm.13207 |
| format | Article |
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Metabolites are the essential substrates for epigenetic modification enzymes to write or erase the epigenetic blueprint in cells. Hence, the availability of nutrients and activity of metabolic pathways strongly influence the enzymatic function. Recent studies have shed light on the choreography between metabolome and epigenome in the control of immune cell differentiation and function, with a major focus on histone modifications. Yet, despite its importance in gene regulation, DNA methylation and its relationship with metabolism is relatively unclear. In this review, we will describe how the metabolic flux can influence epigenetic networks in innate and adaptive immune cells, with a focus on the DNA methylation cycle and the metabolites S‐adenosylmethionine and α‐ketoglutarate. Future directions will be discussed for this rapidly emerging field.
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Metabolites are the essential substrates for epigenetic modification enzymes to write or erase the epigenetic blueprint in cells. Hence, the availability of nutrients and activity of metabolic pathways strongly influence the enzymatic function. Recent studies have shed light on the choreography between metabolome and epigenome in the control of immune cell differentiation and function, with a major focus on histone modifications. Yet, despite its importance in gene regulation, DNA methylation and its relationship with metabolism is relatively unclear. In this review, we will describe how the metabolic flux can influence epigenetic networks in innate and adaptive immune cells, with a focus on the DNA methylation cycle and the metabolites S‐adenosylmethionine and α‐ketoglutarate. Future directions will be discussed for this rapidly emerging field.
The interconnected metabolic and DNA methylation cycles.</description><subject>5‐hydroxymethylcytosine</subject><subject>Adenosylmethionine</subject><subject>B cells</subject><subject>Cell differentiation</subject><subject>Deoxyribonucleic acid</subject><subject>Differentiation (biology)</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>DNA methyltransferases</subject><subject>Epigenetics</subject><subject>Gene regulation</subject><subject>Histones</subject><subject>Immune system</subject><subject>Immunity</subject><subject>immunometabolism</subject><subject>Krebs cycle</subject><subject>macrophages</subject><subject>Metabolic flux</subject><subject>Metabolic pathways</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>mitochondria</subject><subject>Nutrient availability</subject><subject>Nutrients</subject><subject>one‐carbon metabolism</subject><subject>Review</subject><subject>Review Series: The Immunometabolism of Infection</subject><subject>Substrates</subject><subject>T cells</subject><subject>ten–eleven translocation</subject><issn>0019-2805</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kU1PwyAYx4nRuDk9-AVMEy966MZLKa0HEzNfky1e9EwohclsYZZWs28vbnNRE7mQJ_z48Tz8AThGcIjCGpm6HiKCIdsBfURSGmOasl3QhxDlMc4g7YED7-ehJJDSfdAjOEEZhnkfXI9NIyvlI6ejidHqIqqMfTV2FtWqFYWrjIyELSO1MDNlVRtKuVxdaF0U3u2saZeHYE-LyqujzT4Az7c3T-P7ePJ49zC-msQySQiLNWKZEDRnqWJlKQgqU8lyCDXMmMRFganGZYFFoctE4jADThPE8qyUokBIF2QALtfeRVfUqpTKto2o-KIxtWiW3AnDf59Y88Jn7p0zytIsI0FwthE07q1TvuW18VJVlbDKdZ7jBCYkI5glAT39g85d19gwXqAoJilCNA3U-ZqSjfO-UXrbDIL8Kxse_oivsgnsyc_ut-R3GAEYrYEPU6nl_yb-MJ2ulZ-sXZiJ</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Lio, Chan‐Wang Jerry</creator><creator>Huang, Stanley Ching‐Cheng</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QR</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3876-6741</orcidid><orcidid>https://orcid.org/0000-0002-6557-3737</orcidid></search><sort><creationdate>202011</creationdate><title>Circles of Life: linking metabolic and epigenetic cycles to immunity</title><author>Lio, Chan‐Wang Jerry ; Huang, Stanley Ching‐Cheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4437-f178aa5976e7dda31d6c7900f087c2bb25f2db2abfd4c22562641798dcab11fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>5‐hydroxymethylcytosine</topic><topic>Adenosylmethionine</topic><topic>B cells</topic><topic>Cell differentiation</topic><topic>Deoxyribonucleic acid</topic><topic>Differentiation (biology)</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>DNA methyltransferases</topic><topic>Epigenetics</topic><topic>Gene regulation</topic><topic>Histones</topic><topic>Immune system</topic><topic>Immunity</topic><topic>immunometabolism</topic><topic>Krebs cycle</topic><topic>macrophages</topic><topic>Metabolic flux</topic><topic>Metabolic pathways</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>mitochondria</topic><topic>Nutrient availability</topic><topic>Nutrients</topic><topic>one‐carbon metabolism</topic><topic>Review</topic><topic>Review Series: The Immunometabolism of Infection</topic><topic>Substrates</topic><topic>T cells</topic><topic>ten–eleven translocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lio, Chan‐Wang Jerry</creatorcontrib><creatorcontrib>Huang, Stanley Ching‐Cheng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lio, Chan‐Wang Jerry</au><au>Huang, Stanley Ching‐Cheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circles of Life: linking metabolic and epigenetic cycles to immunity</atitle><jtitle>Immunology</jtitle><addtitle>Immunology</addtitle><date>2020-11</date><risdate>2020</risdate><volume>161</volume><issue>3</issue><spage>165</spage><epage>174</epage><pages>165-174</pages><issn>0019-2805</issn><eissn>1365-2567</eissn><abstract>Summary
Metabolites are the essential substrates for epigenetic modification enzymes to write or erase the epigenetic blueprint in cells. Hence, the availability of nutrients and activity of metabolic pathways strongly influence the enzymatic function. Recent studies have shed light on the choreography between metabolome and epigenome in the control of immune cell differentiation and function, with a major focus on histone modifications. Yet, despite its importance in gene regulation, DNA methylation and its relationship with metabolism is relatively unclear. In this review, we will describe how the metabolic flux can influence epigenetic networks in innate and adaptive immune cells, with a focus on the DNA methylation cycle and the metabolites S‐adenosylmethionine and α‐ketoglutarate. Future directions will be discussed for this rapidly emerging field.
The interconnected metabolic and DNA methylation cycles.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32418209</pmid><doi>10.1111/imm.13207</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-3876-6741</orcidid><orcidid>https://orcid.org/0000-0002-6557-3737</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete; Wiley Free Content; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | 5‐hydroxymethylcytosine Adenosylmethionine B cells Cell differentiation Deoxyribonucleic acid Differentiation (biology) DNA DNA methylation DNA methyltransferases Epigenetics Gene regulation Histones Immune system Immunity immunometabolism Krebs cycle macrophages Metabolic flux Metabolic pathways Metabolism Metabolites mitochondria Nutrient availability Nutrients one‐carbon metabolism Review Review Series: The Immunometabolism of Infection Substrates T cells ten–eleven translocation |
| title | Circles of Life: linking metabolic and epigenetic cycles to immunity |
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