The potential roles of NAD(P)H:quinone oxidoreductase 1 in the development of diabetic nephropathy and actin polymerization

Diabetic nephropathy (DN) is a major complication of diabetes mellitus. NAD(P)H:quinone oxidoreductase 1 (NQO1) is an antioxidant enzyme that has been involved in the progression of several kidney injuries. However, the roles of NQO1 in DN are still unclear. We investigated the effects of NQO1 defic...

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Veröffentlicht in:	Scientific reports 2020-10, Vol.10 (1), p.17735-17735, Article 17735
Hauptverfasser:	Moon, Sung-Je, Jeong, Jin Young, Kim, Jae-Hoon, Choi, Dong-Hee, Choi, Hyunsu, Chang, Yoon-Kyung, Na, Ki Ryang, Lee, Kang Wook, Lee, Chul-Ho, Choi, Dae Eun, Hwang, Jung Hwan
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337 631/80 692/4022 692/420 692/699 Actins - metabolism Animals Cells, Cultured Diabetic Nephropathies - metabolism Disease Models, Animal Humanities and Social Sciences Humans Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Lipopolysaccharides - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout multidisciplinary NAD(P)H Dehydrogenase (Quinone) - genetics NAD(P)H Dehydrogenase (Quinone) - metabolism NADP - metabolism Polymerization Science Science (multidisciplinary) Streptozocin
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