VMAT2 Safeguards β-Cells Against Dopamine Cytotoxicity Under High-Fat Diet-Induced Stress

Vesicular monoamine transporter 2 (VMAT2) uptakes cytoplasmic monoamines into vesicles for storage. VMAT2 plays a role in modulating insulin release by regulating dopamine levels in the pancreas, although the exact mechanism remains elusive. We found that VMAT2 expression in β-cells specifically inc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2020-11, Vol.69 (11), p.2377-2391
Hauptverfasser:	Sakano, Daisuke, Uefune, Fumiya, Tokuma, Hiraku, Sonoda, Yuki, Matsuura, Kumi, Takeda, Naoki, Nakagata, Naomi, Kume, Kazuhiko, Shiraki, Nobuaki, Kume, Shoen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amine oxidase (flavin-containing) Animals Beta cells Blood Glucose Cell Line Cell Survival - drug effects Cytotoxicity Diet, High-Fat Dietary Fats - adverse effects Dopamine Dopamine - metabolism Gene Expression Regulation Glucose Glucose tolerance Glucose Tolerance Test High fat diet Hyperglycemia Insulin Insulin secretion Insulin-Secreting Cells - metabolism Islet Studies Mice Mice, Inbred Strains Mice, Knockout Obesity - chemically induced Oxidative stress Pancreas Reactive Oxygen Species Secretion Vesicular Monoamine Transport Proteins - genetics Vesicular Monoamine Transport Proteins - metabolism Vesicular monoamine transporter 2
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!