A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets

The identification of true substrates of an E3 ligase is biologically important but biochemically difficult. In recent years, several techniques for identifying substrates have been developed, but these approaches cannot exclude indirect ubiquitination or have other limitations. Here we develop an E...

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Veröffentlicht in:	Communications biology 2020-10, Vol.3 (1), p.592-592, Article 592
Hauptverfasser:	Watanabe, Masashi, Saeki, Yasushi, Takahashi, Hidehisa, Ohtake, Fumiaki, Yoshida, Yukiko, Kasuga, Yusuke, Kondo, Takeshi, Yaguchi, Hiroaki, Suzuki, Masanobu, Ishida, Hiroki, Tanaka, Keiji, Hatakeyama, Shigetsugu
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 631/1647/2067 631/45/607/468 631/80/474/582 82/58 Biology Biomedical and Life Sciences Cyclin A Life Sciences S phase Transcription initiation factor TFIIB Trapping Ubiquitin Ubiquitin-protein ligase Ubiquitination
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