Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

Many unknowns exist about human immune responses to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2-reactive CD4 T cells have been reported in unexposed individuals, suggesting preexisting cross-reactive T cell memory in 20 to 50% of people. However, the source of...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2020-10, Vol.370 (6512), p.89-94
Hauptverfasser:	Mateus, Jose, Grifoni, Alba, Tarke, Alison, Sidney, John, Ramirez, Sydney I, Dan, Jennifer M, Burger, Zoe C, Rawlings, Stephen A, Smith, Davey M, Phillips, Elizabeth, Mallal, Simon, Lammers, Marshall, Rubiro, Paul, Quiambao, Lorenzo, Sutherland, Aaron, Yu, Esther Dawen, da Silva Antunes, Ricardo, Greenbaum, Jason, Frazier, April, Markmann, Alena J, Premkumar, Lakshmanane, de Silva, Aravinda, Peters, Bjoern, Crotty, Shane, Sette, Alessandro, Weiskopf, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	Betacoronavirus - genetics Betacoronavirus - immunology Blood Donors CD4 antigen CD4-Positive T-Lymphocytes - immunology Colds Common cold Coronaviridae Coronavirus Infections - immunology Coronaviruses COVID-19 Cross Reactions Epitope Mapping Epitopes Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology Genome, Viral Genomes Heterogeneity Homology Humans Immune response Immune system Immunologic Memory Immunological memory Immunology Interrogation Lymphocytes Lymphocytes T Memory Memory cells Microbio Open Reading Frames Pandemics Pneumonia, Viral - immunology Reactivity Respiratory diseases SARS-CoV-2 Sequence Homology Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Viral diseases Viruses
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