Neural stem cells derived from the developing forebrain of YAC128 mice exhibit pathological features of Huntington’s disease

Objectives Huntington's disease (HD) is a devastating neurodegenerative disease caused by polyglutamine (polyQ) expansion in the huntingtin (HTT) gene. Mutant huntingtin (mHTT) is the main cause of HD and is associated with impaired mitochondrial dynamics, ubiquitin‐proteasome system and autoph...

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Veröffentlicht in:	Cell proliferation 2020-10, Vol.53 (10), p.e12893-n/a
Hauptverfasser:	Li, Endan, Park, Hee Ra, Hong, Chang Pyo, Kim, Younghoon, Choi, Jiwoo, Lee, Suji, Park, Hyun Jung, Lee, Bomi, Kim, Tae Aug, Kim, Seong Jin, Kim, Hyun Sook, Song, Jihwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Antibodies Artificial chromosomes Autophagy Axonal transport Biotechnology Calcium (intracellular) Calcium (mitochondrial) Calcium ions Chromosomes Deoxyribonucleic acid DNA Drug screening Embryos Epidermal growth factor Forebrain Huntingtin Huntington's disease Huntingtons disease Laboratories Membrane potential Mitochondria mutant Huntingtin Mutants Neural stem cells Neurodegenerative diseases Original Pathogenesis Penicillin Phagocytosis Polyglutamine diseases Proteasomes Sodium channels (voltage-gated) Stem cell transplantation Stem cells Tau protein Transgenic mice Trinucleotide repeat diseases Trinucleotide repeats Ubiquitin YAC128 transgenic mice Yeast artificial chromosomes Yeasts
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