Demographical and Clinical Features of Marginal Zone Lymphomas: A Retrospective Study of Turkish Oncology Group (TOG)
Marginal zone lymphomas (MZLs) are rare and indolent subtypes of non-Hodgkin lymphomas, and their clinical behaviours are heterogeneous. The aim of this study was to evaluate the clinical and prognostic characteristics of MZL. In this multicentre retrospective study, we analyzed demographical, clini...
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| Veröffentlicht in: | Indian journal of hematology & blood transfusion 2020-10, Vol.36 (4), p.640-645 |
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| creator | Türkkan, Görkem Alkan, Ali Paydaş, Semra Tanrıverdi, Özgür Karakaş, Yusuf Karadurmuş, Nuri Sakin, Abdullah Temiz, Süleyman Arpacı, Erkan Akın, Mustafa Menekşe, Serkan Şen, Cenk Ahmet Barışta, İbrahim |
| description | Marginal zone lymphomas (MZLs) are rare and indolent subtypes of non-Hodgkin lymphomas, and their clinical behaviours are heterogeneous. The aim of this study was to evaluate the clinical and prognostic characteristics of MZL. In this multicentre retrospective study, we analyzed demographical, clinical and prognostic features of 64 MZL patients. The median age was 54.0 and 78.1% of the patients had extra-nodal disease at presentation. Most of the patients were treated with chemotherapy. The 5 years and 10 years overall survival (OS) rates were 74.5% and 62.1%, respectively. The analysis of factors associated with OS showed that ECOG performance score was an important prognostic factor, with 133.0 months (95% CI 49.3–216.5) versus 18.0 months (95% CI 12.1–23.7) for ECOG 0–1 and 2–3, respectively (
p
= 0.011). Prognosis of MZL is favorable and ECOG performance score was found associated with OS. Further detailed studies with large patient numbers are needed to clarify the clinical features and treatment management of MZLs. |
| doi_str_mv | 10.1007/s12288-020-01257-0 |
| format | Article |
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p
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p
= 0.011). Prognosis of MZL is favorable and ECOG performance score was found associated with OS. Further detailed studies with large patient numbers are needed to clarify the clinical features and treatment management of MZLs.</description><subject>Blood Transfusion Medicine</subject><subject>Chemotherapy</subject><subject>Demographics</subject><subject>Epidemiology</subject><subject>Hematology</subject><subject>Human Genetics</subject><subject>Lymphoma</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Radiation therapy</subject><issn>0971-4502</issn><issn>0974-0449</issn><issn>0974-0449</issn><issn>0971-4502</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU9v1DAQxSNERUvhC3CyxKUcAmPHf1IOSNVCF6StVoLlwsVy7EnWJYlTO6m0357sbgWih57GY7_3G2telr2h8J4CqA-JMlaWOTDIgTKhcniWncGl4jlwfvn8cKY5F8BOs5cp3QJIWnDxIjstij0AxFk2fcYuNNEMW29NS0zvyKL1_aG5RjNOERMJNbkxsfH9fPkr9EhWu27Yhs6kj-SKfMcxhjSgHf09kh_j5HZ7x2aKv33aknVvQxuaHVnGMA3kYrNevnuVndSmTfj6oZ5nP6-_bBZf89V6-W1xtcotBzbm1DklKicrWXGqaiN4WSphHWLJkRkoK1pWqnamkmhAQMGtkswxS0E6iWVxnn06coep6tBZ7MdoWj1E35m408F4_f9L77e6CfdaCVWAkDPg4gEQw92EadSdTxbb1vQYpqQZF5xT4Go_6-0j6W2Y4ryyg4pRKCUXs4odVXbeWYpY__0MBb0PRR9T1XOq-pCqhtlUHE1pFvcNxn_oJ1x_ACOapHo</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Türkkan, Görkem</creator><creator>Alkan, Ali</creator><creator>Paydaş, Semra</creator><creator>Tanrıverdi, Özgür</creator><creator>Karakaş, Yusuf</creator><creator>Karadurmuş, Nuri</creator><creator>Sakin, Abdullah</creator><creator>Temiz, Süleyman</creator><creator>Arpacı, Erkan</creator><creator>Akın, Mustafa</creator><creator>Menekşe, Serkan</creator><creator>Şen, Cenk Ahmet</creator><creator>Barışta, İbrahim</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9084-2599</orcidid></search><sort><creationdate>20201001</creationdate><title>Demographical and Clinical Features of Marginal Zone Lymphomas: A Retrospective Study of Turkish Oncology Group (TOG)</title><author>Türkkan, Görkem ; Alkan, Ali ; Paydaş, Semra ; Tanrıverdi, Özgür ; Karakaş, Yusuf ; Karadurmuş, Nuri ; Sakin, Abdullah ; Temiz, Süleyman ; Arpacı, Erkan ; Akın, Mustafa ; Menekşe, Serkan ; Şen, Cenk Ahmet ; Barışta, İbrahim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-1dd75bd6b6b417fa548875cdee84e2a08b18b7fdab6ea05034c762d2c106d6e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Blood Transfusion Medicine</topic><topic>Chemotherapy</topic><topic>Demographics</topic><topic>Epidemiology</topic><topic>Hematology</topic><topic>Human Genetics</topic><topic>Lymphoma</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Pathology</topic><topic>Radiation therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Türkkan, Görkem</creatorcontrib><creatorcontrib>Alkan, Ali</creatorcontrib><creatorcontrib>Paydaş, Semra</creatorcontrib><creatorcontrib>Tanrıverdi, Özgür</creatorcontrib><creatorcontrib>Karakaş, Yusuf</creatorcontrib><creatorcontrib>Karadurmuş, Nuri</creatorcontrib><creatorcontrib>Sakin, Abdullah</creatorcontrib><creatorcontrib>Temiz, Süleyman</creatorcontrib><creatorcontrib>Arpacı, Erkan</creatorcontrib><creatorcontrib>Akın, Mustafa</creatorcontrib><creatorcontrib>Menekşe, Serkan</creatorcontrib><creatorcontrib>Şen, Cenk Ahmet</creatorcontrib><creatorcontrib>Barışta, İbrahim</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of hematology & blood transfusion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Türkkan, Görkem</au><au>Alkan, Ali</au><au>Paydaş, Semra</au><au>Tanrıverdi, Özgür</au><au>Karakaş, Yusuf</au><au>Karadurmuş, Nuri</au><au>Sakin, Abdullah</au><au>Temiz, Süleyman</au><au>Arpacı, Erkan</au><au>Akın, Mustafa</au><au>Menekşe, Serkan</au><au>Şen, Cenk Ahmet</au><au>Barışta, İbrahim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Demographical and Clinical Features of Marginal Zone Lymphomas: A Retrospective Study of Turkish Oncology Group (TOG)</atitle><jtitle>Indian journal of hematology & blood transfusion</jtitle><stitle>Indian J Hematol Blood Transfus</stitle><date>2020-10-01</date><risdate>2020</risdate><volume>36</volume><issue>4</issue><spage>640</spage><epage>645</epage><pages>640-645</pages><issn>0971-4502</issn><issn>0974-0449</issn><eissn>0974-0449</eissn><eissn>0971-4502</eissn><abstract>Marginal zone lymphomas (MZLs) are rare and indolent subtypes of non-Hodgkin lymphomas, and their clinical behaviours are heterogeneous. The aim of this study was to evaluate the clinical and prognostic characteristics of MZL. In this multicentre retrospective study, we analyzed demographical, clinical and prognostic features of 64 MZL patients. The median age was 54.0 and 78.1% of the patients had extra-nodal disease at presentation. Most of the patients were treated with chemotherapy. The 5 years and 10 years overall survival (OS) rates were 74.5% and 62.1%, respectively. The analysis of factors associated with OS showed that ECOG performance score was an important prognostic factor, with 133.0 months (95% CI 49.3–216.5) versus 18.0 months (95% CI 12.1–23.7) for ECOG 0–1 and 2–3, respectively (
p
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| source | Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Blood Transfusion Medicine Chemotherapy Demographics Epidemiology Hematology Human Genetics Lymphoma Medical prognosis Medicine Medicine & Public Health Oncology Original Original Article Pathology Radiation therapy |
| title | Demographical and Clinical Features of Marginal Zone Lymphomas: A Retrospective Study of Turkish Oncology Group (TOG) |
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