Large scale, robust, and accurate whole transcriptome profiling from clinical formalin-fixed paraffin-embedded samples

Transcriptome profiling can provide information of great value in clinical decision-making, yet RNA from readily available formalin-fixed paraffin-embedded (FFPE) tissue is often too degraded for quality sequencing. To assess the clinical utility of FFPE-derived RNA, we performed ribo-deplete RNA ex...

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Veröffentlicht in:	Scientific reports 2020-10, Vol.10 (1), p.17597-17597, Article 17597
Hauptverfasser:	Newton, Yulia, Sedgewick, Andrew J., Cisneros, Luis, Golovato, Justin, Johnson, Mark, Szeto, Christopher W., Rabizadeh, Shahrooz, Sanborn, J. Zachary, Benz, Stephen Charles, Vaske, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114 631/114/1314 631/114/2163 631/114/2400 631/114/2401 631/114/2413 631/114/2415 631/337 631/61 631/67 692/308 692/4017 692/4028 692/4028/67/1059 692/4028/67/1857 692/4028/67/2322 692/4028/67/69 692/53 Computational Biology Databases, Factual Gene Expression Profiling - methods High-Throughput Nucleotide Sequencing - methods Humanities and Social Sciences Humans multidisciplinary Paraffin Embedding Reproducibility of Results Science Science (multidisciplinary) Sequence Analysis, RNA Tissue Fixation - methods
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