Preferential transcription of the mutated allele in NPM1 mutated acute myeloid leukaemia

Nucleophosmin is commonly both over-expressed and mutated in acute myeloid leukemia (AML). NPM1 mutations are always heterozygous. In addition, NPM1 has a number of different splice variants with the major variant encoded by exons 1–9 and 11–12 ( NPM1.1 ). Further variants include NPM1.2 which lacks...

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Veröffentlicht in:	Scientific reports 2020-10, Vol.10 (1), p.17695-17695, Article 17695
Hauptverfasser:	Bailey, G. D., Doolan, L., Baskar, A., Smith, L. C., Seedhouse, C. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2017/2003 692/4028/67/1990/283/1897 Alleles Humanities and Social Sciences Humans Leukemia, Myeloid, Acute - genetics multidisciplinary Mutation Nuclear Proteins - genetics Science Science (multidisciplinary) Transcription, Genetic
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