Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions

Vascular endothelial growth factor A (VEGFA) stimulates angiogenesis in human endothelial cells, and increasing its expression is a potential treatment for heart failure. Here, we report the design of a small molecule (TGP-377) that specifically and potently enhances VEGFA expression by the targetin...

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Veröffentlicht in:	Nature chemistry 2020-10, Vol.12 (10), p.952-961
Hauptverfasser:	Haniff, Hafeez S., Knerr, Laurent, Liu, Xiaohui, Crynen, Gogce, Boström, Jonas, Abegg, Daniel, Adibekian, Alexander, Lekah, Elizabeth, Wang, Kye Won, Cameron, Michael D., Yildirim, Ilyas, Lemurell, Malin, Disney, Matthew D.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/500 639/638/309 639/638/630 Analytical Chemistry Angiogenesis Biochemistry Biomolecules Chemistry Chemistry and Materials Science Chemistry/Food Science Combinatorial analysis Congestive heart failure Datasets Design Drug Design Drug Evaluation, Preclinical Endothelial cells Growth factors Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Inorganic Chemistry MicroRNAs MicroRNAs - chemistry MicroRNAs - genetics MicroRNAs - metabolism miRNA Molecular Structure mRNA Organic Chemistry Physical Chemistry Ribonucleic acid RNA RNA Folding Screening Small Molecule Libraries - chemical synthesis Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Umbilical vein Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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