Intraindividual comparison between 68Ga-PSMA-PET/CT and mpMRI for intraprostatic tumor delineation in patients with primary prostate cancer: a retrospective analysis in 101 patients
Purpose Accurate delineation of intraprostatic gross tumor volume (GTV) is mandatory for successful fusion biopsy guidance and focal therapy planning of prostate cancer (PCa). Multiparametric magnetic resonance imaging (mpMRI) is the current gold standard for GTV delineation; however, prostate-speci...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2020-11, Vol.47 (12), p.2796-2803 |
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| creator | Spohn, Simon Jaegle, Chiara Fassbender, Thomas F. Sprave, Tanja Gkika, Eleni Nicolay, Nils H. Bock, Michael Ruf, Juri Benndorf, Matthias Gratzke, Christian Grosu, Anca L. Zamboglou, Constantinos |
| description | Purpose
Accurate delineation of intraprostatic gross tumor volume (GTV) is mandatory for successful fusion biopsy guidance and focal therapy planning of prostate cancer (PCa). Multiparametric magnetic resonance imaging (mpMRI) is the current gold standard for GTV delineation; however, prostate-specific membrane antigen positron emission tomography (PSMA-PET) is emerging as a promising alternative. This study compares GTV delineation between mpMRI and
68
Ga-PSMA-PET in a large number of patients using validated contouring approaches.
Methods
One hundred one patients with biopsy-proven primary PCa who underwent mpMRI and
68
Ga-PSMA-PET within 3 months before primary treatment were retrospectively enrolled. Clinical parameters (age, PSA, Gleason score in biopsy) were documented. GTV based on MRI and PET images were delineated; volumes measured and laterality determined. Additionally, biopsy data from 77 patients was analyzed. Univariate and multivariate binary logistic regression analyses were performed using concordance in laterality as the endpoint.
Results
In total mpMRI and
68
Ga-PSMA-PET detected 151 and 159 lesions, respectively. Median GTV-MRI (2.8 ml, 95% CI 2.31–3.38 ml) was significantly (
p
|
| doi_str_mv | 10.1007/s00259-020-04827-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7567709</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2395605501</sourcerecordid><originalsourceid>FETCH-LOGICAL-c381t-b11c20c66a84b96ad3304296c7fef3f63c90fffc2fc98b17a6e1b5586da491fe3</originalsourceid><addsrcrecordid>eNp9ks1u1DAUhSMEoqXwAqwssWET6p_EjlkgVaO2jNSKCoa15TjXravECbYzVR-M98NhRlOVBStfXZ_z-frqFMV7gj8RjMVpxJjWssQUl7hqqCj5i-KYcCJLgRv58lALfFS8ifEeY9LQRr4ujhhlFSWSHhe_1z4F7Xzntq6bdY_MOEw6uDh61EJ6APCIN5e6vPlxfVbenG9OVxukfYeG6fr7GtkxILcQpjDGpJMzKM1DbnbQOw-5kTnOoylX4FNEDy7doSm4QYdHtDcBMtobCJ-RRgFSbk5gkttCfkj3j9HFBUEwOWDeFq-s7iO8258nxc-L883qa3n17XK9OrsqDWtIKltCDMWGc91UreS6YwxXVHIjLFhmOTMSW2sNtUY2LRGaA2nruuGdriSxwE6KLzvuNLcDdAaWr_ZqP78atVPPb7y7U7fjVomaC4FlBnzcA8L4a4aY1OCigb7XHsY5KspkzXFdY5KlH_6R3o9zyAvIqlrIRrA8eVbRncrkNcUA9jAMwWpJhdqlQuVUqL-pUIuJ7Uwxi_0thCf0f1x_AM5tvTk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2579873296</pqid></control><display><type>article</type><title>Intraindividual comparison between 68Ga-PSMA-PET/CT and mpMRI for intraprostatic tumor delineation in patients with primary prostate cancer: a retrospective analysis in 101 patients</title><source>SpringerLink Journals - AutoHoldings</source><creator>Spohn, Simon ; Jaegle, Chiara ; Fassbender, Thomas F. ; Sprave, Tanja ; Gkika, Eleni ; Nicolay, Nils H. ; Bock, Michael ; Ruf, Juri ; Benndorf, Matthias ; Gratzke, Christian ; Grosu, Anca L. ; Zamboglou, Constantinos</creator><creatorcontrib>Spohn, Simon ; Jaegle, Chiara ; Fassbender, Thomas F. ; Sprave, Tanja ; Gkika, Eleni ; Nicolay, Nils H. ; Bock, Michael ; Ruf, Juri ; Benndorf, Matthias ; Gratzke, Christian ; Grosu, Anca L. ; Zamboglou, Constantinos</creatorcontrib><description>Purpose
Accurate delineation of intraprostatic gross tumor volume (GTV) is mandatory for successful fusion biopsy guidance and focal therapy planning of prostate cancer (PCa). Multiparametric magnetic resonance imaging (mpMRI) is the current gold standard for GTV delineation; however, prostate-specific membrane antigen positron emission tomography (PSMA-PET) is emerging as a promising alternative. This study compares GTV delineation between mpMRI and
68
Ga-PSMA-PET in a large number of patients using validated contouring approaches.
Methods
One hundred one patients with biopsy-proven primary PCa who underwent mpMRI and
68
Ga-PSMA-PET within 3 months before primary treatment were retrospectively enrolled. Clinical parameters (age, PSA, Gleason score in biopsy) were documented. GTV based on MRI and PET images were delineated; volumes measured and laterality determined. Additionally, biopsy data from 77 patients was analyzed. Univariate and multivariate binary logistic regression analyses were performed using concordance in laterality as the endpoint.
Results
In total mpMRI and
68
Ga-PSMA-PET detected 151 and 159 lesions, respectively. Median GTV-MRI (2.8 ml, 95% CI 2.31–3.38 ml) was significantly (
p
< 0.0001) smaller than median GTV-PET (4.9 ml, 95% CI 3.9–6.6 ml).
68
Ga-PSMA-PET detected significantly more bilateral lesions than mpMRI (71 vs 57,
p
= 0.03). Analysis of patients with bilateral lesions in biopsy showed a significant higher concordance of laterality in
68
Ga-PSMA-PET (
p
= 0.03). In univariate analysis, PSA level and volume of GTV-MRI had an impact on concordance in laterality (
p
= 0.02 and
p
= 0.01), whereas in multivariate analysis, only GTV-MRI volume remained significant (
p
= 0.04).
Conclusion
MpMRI and
68
Ga-PSMA-PET detect a similar amount of PCa lesions. However, GTV-PET had approximately twice the volume (median 4.9 ml vs 2.8 ml) and detected significantly more bilateral lesions than mpMRI. Thus,
68
Ga-PSMA-PET gives highly important complementary information. Since we could not find any strong evidence for parameters to guide when
68
Ga-PSMA-PET is dispensable, it should be performed additionally to MRI in patients with intermediate and high-risk PCa according to D’Amico classification to improve GTV delineation.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-020-04827-6</identifier><identifier>PMID: 32342192</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Antigens ; Biopsy ; Cardiology ; Computed tomography ; Contouring ; Delineation ; Emission analysis ; Imaging ; Lesions ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Multivariate analysis ; Nuclear Medicine ; Oncology ; Oncology – Genitourinary ; Original ; Original Article ; Orthopedics ; Parameters ; Patients ; Positron emission ; Positron emission tomography ; Prostate cancer ; Radiology ; Tomography ; Tumors</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2020-11, Vol.47 (12), p.2796-2803</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-b11c20c66a84b96ad3304296c7fef3f63c90fffc2fc98b17a6e1b5586da491fe3</citedby><cites>FETCH-LOGICAL-c381t-b11c20c66a84b96ad3304296c7fef3f63c90fffc2fc98b17a6e1b5586da491fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-020-04827-6$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-020-04827-6$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Spohn, Simon</creatorcontrib><creatorcontrib>Jaegle, Chiara</creatorcontrib><creatorcontrib>Fassbender, Thomas F.</creatorcontrib><creatorcontrib>Sprave, Tanja</creatorcontrib><creatorcontrib>Gkika, Eleni</creatorcontrib><creatorcontrib>Nicolay, Nils H.</creatorcontrib><creatorcontrib>Bock, Michael</creatorcontrib><creatorcontrib>Ruf, Juri</creatorcontrib><creatorcontrib>Benndorf, Matthias</creatorcontrib><creatorcontrib>Gratzke, Christian</creatorcontrib><creatorcontrib>Grosu, Anca L.</creatorcontrib><creatorcontrib>Zamboglou, Constantinos</creatorcontrib><title>Intraindividual comparison between 68Ga-PSMA-PET/CT and mpMRI for intraprostatic tumor delineation in patients with primary prostate cancer: a retrospective analysis in 101 patients</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
Accurate delineation of intraprostatic gross tumor volume (GTV) is mandatory for successful fusion biopsy guidance and focal therapy planning of prostate cancer (PCa). Multiparametric magnetic resonance imaging (mpMRI) is the current gold standard for GTV delineation; however, prostate-specific membrane antigen positron emission tomography (PSMA-PET) is emerging as a promising alternative. This study compares GTV delineation between mpMRI and
68
Ga-PSMA-PET in a large number of patients using validated contouring approaches.
Methods
One hundred one patients with biopsy-proven primary PCa who underwent mpMRI and
68
Ga-PSMA-PET within 3 months before primary treatment were retrospectively enrolled. Clinical parameters (age, PSA, Gleason score in biopsy) were documented. GTV based on MRI and PET images were delineated; volumes measured and laterality determined. Additionally, biopsy data from 77 patients was analyzed. Univariate and multivariate binary logistic regression analyses were performed using concordance in laterality as the endpoint.
Results
In total mpMRI and
68
Ga-PSMA-PET detected 151 and 159 lesions, respectively. Median GTV-MRI (2.8 ml, 95% CI 2.31–3.38 ml) was significantly (
p
< 0.0001) smaller than median GTV-PET (4.9 ml, 95% CI 3.9–6.6 ml).
68
Ga-PSMA-PET detected significantly more bilateral lesions than mpMRI (71 vs 57,
p
= 0.03). Analysis of patients with bilateral lesions in biopsy showed a significant higher concordance of laterality in
68
Ga-PSMA-PET (
p
= 0.03). In univariate analysis, PSA level and volume of GTV-MRI had an impact on concordance in laterality (
p
= 0.02 and
p
= 0.01), whereas in multivariate analysis, only GTV-MRI volume remained significant (
p
= 0.04).
Conclusion
MpMRI and
68
Ga-PSMA-PET detect a similar amount of PCa lesions. However, GTV-PET had approximately twice the volume (median 4.9 ml vs 2.8 ml) and detected significantly more bilateral lesions than mpMRI. Thus,
68
Ga-PSMA-PET gives highly important complementary information. Since we could not find any strong evidence for parameters to guide when
68
Ga-PSMA-PET is dispensable, it should be performed additionally to MRI in patients with intermediate and high-risk PCa according to D’Amico classification to improve GTV delineation.</description><subject>Antigens</subject><subject>Biopsy</subject><subject>Cardiology</subject><subject>Computed tomography</subject><subject>Contouring</subject><subject>Delineation</subject><subject>Emission analysis</subject><subject>Imaging</subject><subject>Lesions</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multivariate analysis</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Oncology – Genitourinary</subject><subject>Original</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Parameters</subject><subject>Patients</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Prostate cancer</subject><subject>Radiology</subject><subject>Tomography</subject><subject>Tumors</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp9ks1u1DAUhSMEoqXwAqwssWET6p_EjlkgVaO2jNSKCoa15TjXravECbYzVR-M98NhRlOVBStfXZ_z-frqFMV7gj8RjMVpxJjWssQUl7hqqCj5i-KYcCJLgRv58lALfFS8ifEeY9LQRr4ujhhlFSWSHhe_1z4F7Xzntq6bdY_MOEw6uDh61EJ6APCIN5e6vPlxfVbenG9OVxukfYeG6fr7GtkxILcQpjDGpJMzKM1DbnbQOw-5kTnOoylX4FNEDy7doSm4QYdHtDcBMtobCJ-RRgFSbk5gkttCfkj3j9HFBUEwOWDeFq-s7iO8258nxc-L883qa3n17XK9OrsqDWtIKltCDMWGc91UreS6YwxXVHIjLFhmOTMSW2sNtUY2LRGaA2nruuGdriSxwE6KLzvuNLcDdAaWr_ZqP78atVPPb7y7U7fjVomaC4FlBnzcA8L4a4aY1OCigb7XHsY5KspkzXFdY5KlH_6R3o9zyAvIqlrIRrA8eVbRncrkNcUA9jAMwWpJhdqlQuVUqL-pUIuJ7Uwxi_0thCf0f1x_AM5tvTk</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Spohn, Simon</creator><creator>Jaegle, Chiara</creator><creator>Fassbender, Thomas F.</creator><creator>Sprave, Tanja</creator><creator>Gkika, Eleni</creator><creator>Nicolay, Nils H.</creator><creator>Bock, Michael</creator><creator>Ruf, Juri</creator><creator>Benndorf, Matthias</creator><creator>Gratzke, Christian</creator><creator>Grosu, Anca L.</creator><creator>Zamboglou, Constantinos</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201101</creationdate><title>Intraindividual comparison between 68Ga-PSMA-PET/CT and mpMRI for intraprostatic tumor delineation in patients with primary prostate cancer: a retrospective analysis in 101 patients</title><author>Spohn, Simon ; Jaegle, Chiara ; Fassbender, Thomas F. ; Sprave, Tanja ; Gkika, Eleni ; Nicolay, Nils H. ; Bock, Michael ; Ruf, Juri ; Benndorf, Matthias ; Gratzke, Christian ; Grosu, Anca L. ; Zamboglou, Constantinos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-b11c20c66a84b96ad3304296c7fef3f63c90fffc2fc98b17a6e1b5586da491fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antigens</topic><topic>Biopsy</topic><topic>Cardiology</topic><topic>Computed tomography</topic><topic>Contouring</topic><topic>Delineation</topic><topic>Emission analysis</topic><topic>Imaging</topic><topic>Lesions</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multivariate analysis</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Oncology – Genitourinary</topic><topic>Original</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Parameters</topic><topic>Patients</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Prostate cancer</topic><topic>Radiology</topic><topic>Tomography</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spohn, Simon</creatorcontrib><creatorcontrib>Jaegle, Chiara</creatorcontrib><creatorcontrib>Fassbender, Thomas F.</creatorcontrib><creatorcontrib>Sprave, Tanja</creatorcontrib><creatorcontrib>Gkika, Eleni</creatorcontrib><creatorcontrib>Nicolay, Nils H.</creatorcontrib><creatorcontrib>Bock, Michael</creatorcontrib><creatorcontrib>Ruf, Juri</creatorcontrib><creatorcontrib>Benndorf, Matthias</creatorcontrib><creatorcontrib>Gratzke, Christian</creatorcontrib><creatorcontrib>Grosu, Anca L.</creatorcontrib><creatorcontrib>Zamboglou, Constantinos</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest 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Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spohn, Simon</au><au>Jaegle, Chiara</au><au>Fassbender, Thomas F.</au><au>Sprave, Tanja</au><au>Gkika, Eleni</au><au>Nicolay, Nils H.</au><au>Bock, Michael</au><au>Ruf, Juri</au><au>Benndorf, Matthias</au><au>Gratzke, Christian</au><au>Grosu, Anca L.</au><au>Zamboglou, Constantinos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraindividual comparison between 68Ga-PSMA-PET/CT and mpMRI for intraprostatic tumor delineation in patients with primary prostate cancer: a retrospective analysis in 101 patients</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><date>2020-11-01</date><risdate>2020</risdate><volume>47</volume><issue>12</issue><spage>2796</spage><epage>2803</epage><pages>2796-2803</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
Accurate delineation of intraprostatic gross tumor volume (GTV) is mandatory for successful fusion biopsy guidance and focal therapy planning of prostate cancer (PCa). Multiparametric magnetic resonance imaging (mpMRI) is the current gold standard for GTV delineation; however, prostate-specific membrane antigen positron emission tomography (PSMA-PET) is emerging as a promising alternative. This study compares GTV delineation between mpMRI and
68
Ga-PSMA-PET in a large number of patients using validated contouring approaches.
Methods
One hundred one patients with biopsy-proven primary PCa who underwent mpMRI and
68
Ga-PSMA-PET within 3 months before primary treatment were retrospectively enrolled. Clinical parameters (age, PSA, Gleason score in biopsy) were documented. GTV based on MRI and PET images were delineated; volumes measured and laterality determined. Additionally, biopsy data from 77 patients was analyzed. Univariate and multivariate binary logistic regression analyses were performed using concordance in laterality as the endpoint.
Results
In total mpMRI and
68
Ga-PSMA-PET detected 151 and 159 lesions, respectively. Median GTV-MRI (2.8 ml, 95% CI 2.31–3.38 ml) was significantly (
p
< 0.0001) smaller than median GTV-PET (4.9 ml, 95% CI 3.9–6.6 ml).
68
Ga-PSMA-PET detected significantly more bilateral lesions than mpMRI (71 vs 57,
p
= 0.03). Analysis of patients with bilateral lesions in biopsy showed a significant higher concordance of laterality in
68
Ga-PSMA-PET (
p
= 0.03). In univariate analysis, PSA level and volume of GTV-MRI had an impact on concordance in laterality (
p
= 0.02 and
p
= 0.01), whereas in multivariate analysis, only GTV-MRI volume remained significant (
p
= 0.04).
Conclusion
MpMRI and
68
Ga-PSMA-PET detect a similar amount of PCa lesions. However, GTV-PET had approximately twice the volume (median 4.9 ml vs 2.8 ml) and detected significantly more bilateral lesions than mpMRI. Thus,
68
Ga-PSMA-PET gives highly important complementary information. Since we could not find any strong evidence for parameters to guide when
68
Ga-PSMA-PET is dispensable, it should be performed additionally to MRI in patients with intermediate and high-risk PCa according to D’Amico classification to improve GTV delineation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32342192</pmid><doi>10.1007/s00259-020-04827-6</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of nuclear medicine and molecular imaging, 2020-11, Vol.47 (12), p.2796-2803 |
| issn | 1619-7070 1619-7089 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Antigens Biopsy Cardiology Computed tomography Contouring Delineation Emission analysis Imaging Lesions Magnetic resonance imaging Medicine Medicine & Public Health Multivariate analysis Nuclear Medicine Oncology Oncology – Genitourinary Original Original Article Orthopedics Parameters Patients Positron emission Positron emission tomography Prostate cancer Radiology Tomography Tumors |
| title | Intraindividual comparison between 68Ga-PSMA-PET/CT and mpMRI for intraprostatic tumor delineation in patients with primary prostate cancer: a retrospective analysis in 101 patients |
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