Gender- and age-related differences in homocysteine concentration: a cross-sectional study of the general population of China
The primary goals of this study were to evaluate the gender- and age-related differences in homocysteine concentration in the general population of China and possible influencing factors. A total of 7872 subjects, divided into male and female groups, participated in this retrospective study. The ave...
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| Veröffentlicht in: | Scientific reports 2020-10, Vol.10 (1), p.17401-17401, Article 17401 |
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| description | The primary goals of this study were to evaluate the gender- and age-related differences in homocysteine concentration in the general population of China and possible influencing factors. A total of 7872 subjects, divided into male and female groups, participated in this retrospective study. The average homocysteine level, prevalence of hyperhomocysteinemia, and independent factors affecting homocysteine concentration were analyzed. The homocysteine level was significantly higher in males than in females in each age range (aged 20–30, aged 30–40, aged 40–50, aged 50–60, aged 60–80, aged over 80) (
P
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| doi_str_mv | 10.1038/s41598-020-74596-7 |
| format | Article |
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P
< 0.0001), and the trend did not abate with age. The homocysteine concentration first decreased and then increased, being lowest at 30–50 years of age and significantly increased after 50 years of age. Factors associated with homocysteine concentration in males were smoking status (current smokers versus ex-smokers: β: 0.112), estimated glomerular filtration rate (
β
= − 0.192), blood urea nitrogen (
β
= − 0.14), diastolic blood pressure (
β
= − 0.113), free triiodothyronine (
β
= − 0.091), serum potassium (
β
= − 0.107) and cystatin C (
β
= 0.173). In females, independent factors associated with homocysteine concentration were cystatin C (
β
= 0.319), albumin (
β
= 0.227), free thyroxine (
β
= 0.179), age (
β
= 0.148), free triiodothyronine (
β
= − 0.217) and serum potassium (
β
= − 0.153). The homocysteine level was significantly higher in males than in females and increased markedly after 50 years of age in both groups. The independent factors associated with increased homocysteine concentration differed between males and females.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-74596-7</identifier><identifier>PMID: 33060744</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308 ; 692/4019 ; 692/499 ; 692/53 ; Adolescent ; Age Factors ; Aged ; Aged, 80 and over ; China ; Cross-Sectional Studies ; Female ; Homocysteine - blood ; Homocysteine - standards ; Humanities and Social Sciences ; Humans ; Male ; Middle Aged ; multidisciplinary ; Reference Standards ; Retrospective Studies ; Science ; Science (multidisciplinary) ; Sex Factors ; Young Adult</subject><ispartof>Scientific reports, 2020-10, Vol.10 (1), p.17401-17401, Article 17401</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-e328f74bc88a3d8c75ad0cefcdb812447cde7375b3e88ced1ea13b6464a152163</citedby><cites>FETCH-LOGICAL-c499t-e328f74bc88a3d8c75ad0cefcdb812447cde7375b3e88ced1ea13b6464a152163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566483/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566483/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33060744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Ranran</creatorcontrib><creatorcontrib>Huang, Fei</creatorcontrib><creatorcontrib>Wang, Yiru</creatorcontrib><creatorcontrib>Liu, Qingquan</creatorcontrib><creatorcontrib>Lv, Yongman</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><title>Gender- and age-related differences in homocysteine concentration: a cross-sectional study of the general population of China</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The primary goals of this study were to evaluate the gender- and age-related differences in homocysteine concentration in the general population of China and possible influencing factors. A total of 7872 subjects, divided into male and female groups, participated in this retrospective study. The average homocysteine level, prevalence of hyperhomocysteinemia, and independent factors affecting homocysteine concentration were analyzed. The homocysteine level was significantly higher in males than in females in each age range (aged 20–30, aged 30–40, aged 40–50, aged 50–60, aged 60–80, aged over 80) (
P
< 0.0001), and the trend did not abate with age. The homocysteine concentration first decreased and then increased, being lowest at 30–50 years of age and significantly increased after 50 years of age. Factors associated with homocysteine concentration in males were smoking status (current smokers versus ex-smokers: β: 0.112), estimated glomerular filtration rate (
β
= − 0.192), blood urea nitrogen (
β
= − 0.14), diastolic blood pressure (
β
= − 0.113), free triiodothyronine (
β
= − 0.091), serum potassium (
β
= − 0.107) and cystatin C (
β
= 0.173). In females, independent factors associated with homocysteine concentration were cystatin C (
β
= 0.319), albumin (
β
= 0.227), free thyroxine (
β
= 0.179), age (
β
= 0.148), free triiodothyronine (
β
= − 0.217) and serum potassium (
β
= − 0.153). The homocysteine level was significantly higher in males than in females and increased markedly after 50 years of age in both groups. The independent factors associated with increased homocysteine concentration differed between males and females.</description><subject>692/308</subject><subject>692/4019</subject><subject>692/499</subject><subject>692/53</subject><subject>Adolescent</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>China</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Homocysteine - blood</subject><subject>Homocysteine - standards</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Reference Standards</subject><subject>Retrospective Studies</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sex Factors</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9UU1rFDEYDqLYUvsHPEiOXqL5nGQ8CLJoFQpe9BwyyTu7KbPJmswIe-h_N7tTS72YS8LzlZf3Qeg1o-8YFeZ9lUz1hlBOiZaq74h-hi45lYpwwfnzJ-8LdF3rHW1H8V6y_iW6EIJ2VEt5ie5vIAUoBLsUsNsCKTC5GQIOcRyhQPJQcUx4l_fZH-sMMQH2ucFpLm6OOX3ADvuSayUV_AlwE67zEo44j3jeAd5CgtLAQz4s09lyYja7mNwr9GJ0U4Xrh_sK_fzy-cfmK7n9fvNt8-mWeNn3MwHBzajl4I1xIhivlQvUw-jDYBiXUvsAWmg1CDDGQ2DgmBg62UnHFGeduEIf19zDMuwhrMNP9lDi3pWjzS7af5kUd3abf1utuk4a0QLePgSU_GuBOtt9rB6mySXIS7VcKmZk10vepHyVnpdSYHz8hlF7qs6u1dlWnT1XZ3UzvXk64KPlb1FNIFZBbVTaQrF3eSlt1_V_sX8ARt-n_w</recordid><startdate>20201015</startdate><enddate>20201015</enddate><creator>Xu, Ranran</creator><creator>Huang, Fei</creator><creator>Wang, Yiru</creator><creator>Liu, Qingquan</creator><creator>Lv, Yongman</creator><creator>Zhang, Qian</creator><general>Nature Publishing Group UK</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201015</creationdate><title>Gender- and age-related differences in homocysteine concentration: a cross-sectional study of the general population of China</title><author>Xu, Ranran ; Huang, Fei ; Wang, Yiru ; Liu, Qingquan ; Lv, Yongman ; Zhang, Qian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-e328f74bc88a3d8c75ad0cefcdb812447cde7375b3e88ced1ea13b6464a152163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/308</topic><topic>692/4019</topic><topic>692/499</topic><topic>692/53</topic><topic>Adolescent</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>China</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Homocysteine - blood</topic><topic>Homocysteine - standards</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Reference Standards</topic><topic>Retrospective Studies</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sex Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Ranran</creatorcontrib><creatorcontrib>Huang, Fei</creatorcontrib><creatorcontrib>Wang, Yiru</creatorcontrib><creatorcontrib>Liu, Qingquan</creatorcontrib><creatorcontrib>Lv, Yongman</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Ranran</au><au>Huang, Fei</au><au>Wang, Yiru</au><au>Liu, Qingquan</au><au>Lv, Yongman</au><au>Zhang, Qian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gender- and age-related differences in homocysteine concentration: a cross-sectional study of the general population of China</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-10-15</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>17401</spage><epage>17401</epage><pages>17401-17401</pages><artnum>17401</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The primary goals of this study were to evaluate the gender- and age-related differences in homocysteine concentration in the general population of China and possible influencing factors. A total of 7872 subjects, divided into male and female groups, participated in this retrospective study. The average homocysteine level, prevalence of hyperhomocysteinemia, and independent factors affecting homocysteine concentration were analyzed. The homocysteine level was significantly higher in males than in females in each age range (aged 20–30, aged 30–40, aged 40–50, aged 50–60, aged 60–80, aged over 80) (
P
< 0.0001), and the trend did not abate with age. The homocysteine concentration first decreased and then increased, being lowest at 30–50 years of age and significantly increased after 50 years of age. Factors associated with homocysteine concentration in males were smoking status (current smokers versus ex-smokers: β: 0.112), estimated glomerular filtration rate (
β
= − 0.192), blood urea nitrogen (
β
= − 0.14), diastolic blood pressure (
β
= − 0.113), free triiodothyronine (
β
= − 0.091), serum potassium (
β
= − 0.107) and cystatin C (
β
= 0.173). In females, independent factors associated with homocysteine concentration were cystatin C (
β
= 0.319), albumin (
β
= 0.227), free thyroxine (
β
= 0.179), age (
β
= 0.148), free triiodothyronine (
β
= − 0.217) and serum potassium (
β
= − 0.153). The homocysteine level was significantly higher in males than in females and increased markedly after 50 years of age in both groups. The independent factors associated with increased homocysteine concentration differed between males and females.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33060744</pmid><doi>10.1038/s41598-020-74596-7</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/308 692/4019 692/499 692/53 Adolescent Age Factors Aged Aged, 80 and over China Cross-Sectional Studies Female Homocysteine - blood Homocysteine - standards Humanities and Social Sciences Humans Male Middle Aged multidisciplinary Reference Standards Retrospective Studies Science Science (multidisciplinary) Sex Factors Young Adult |
| title | Gender- and age-related differences in homocysteine concentration: a cross-sectional study of the general population of China |
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