Blood DNA Methylation and Aging: A Cross-Sectional Analysis and Longitudinal Validation in the InCHIANTI Study

Abstract Changes in DNA methylation have been found to be highly correlated with aging in humans, but causes or consequences of these changes are not understood. We characterized the DNA methylomes of several hundred people in the Invecchiare in Chianti study to identify DNA sites in which percent m...

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2020-11, Vol.75 (11), p.2051-2055
Hauptverfasser:	Tharakan, Ravi, Ubaida-Mohien, Ceereena, Moore, Ann Zenobia, Hernandez, Dena, Tanaka, Toshiko, Ferrucci, Luigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Aging Aging - genetics CCCTC-Binding Factor - genetics Chromatin CpG Islands Cross-Sectional Studies Deoxyribonucleic acid DNA DNA - blood DNA Methylation Epigenetics Epigenomics Female Genes Histone H3 Histones Humans Italy Longitudinal Studies Lysine Male Middle Aged Polycomb group proteins Prospective Studies Protein Binding THE JOURNAL OF GERONTOLOGY: Biological Sciences Transcription Factors - metabolism
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