The Blood Cytokine Profile of Young People with Early Ischemic Heart Disease Comorbid with Abdominal Obesity
Objective: The aim was to study the blood cytokine/chemokine profile of 25–44-year-old people with early ischemic heart disease (IHD) comorbid with abdominal obesity (AO). Methods: A cross-sectional medical examination of subjects in Novosibirsk, Russia, was conducted after random sampling of the ab...
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| Veröffentlicht in: | Journal of personalized medicine 2020-09, Vol.10 (3), p.87 |
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| creator | Ragino, Yulia I Oblaukhova, Veronika I Polonskaya, Yana V Kuzminykh, Natalya A Shcherbakova, Liliya V Kashtanova, Elena V |
| description | Objective: The aim was to study the blood cytokine/chemokine profile of 25–44-year-old people with early ischemic heart disease (IHD) comorbid with abdominal obesity (AO). Methods: A cross-sectional medical examination of subjects in Novosibirsk, Russia, was conducted after random sampling of the above age group. A total of 1457 subjects, 804 females and 653 males, were analyzed. The epidemiological diagnosis of IHD was made in accordance with 17 validated and functional criteria, employing exercise ECG for confirmation. Simultaneous quantitative analyses of 41 cytokines/chemokines in blood serum were performed by a multiplex assay using the HCYTMAG-60K-PX41 panel (MILLIPLEX MAP) on a Luminex 20 MAGPIX flow cytometer, with additional ELISA testing. Results: Flt3 ligand, GM-CSF, and MCP-1 were significantly associated with the relative risk of early IHD. In the presence of AO, GM-CSF, MCP-1 and IL-4 also significantly correlated with the relative risk of early IHD. By univariate regression analysis, the relative risk of early IHD was associated with lowered blood concentrations of Flt3 ligand, whereas the relative risk of early IHD in the presence of AO was associated with lowered blood concentrations of GM-CSF. Employing multivariable regression analysis, only lower blood levels of Flt3 ligand were associated with a relative risk of early IHD, whereas the relative risk of early IHD in the presence of AO was limited to lower levels of IL-4. Conclusion: Findings related to Flt3 ligand, GM-CSF, and IL-4 are consistent with the international literature. Results from the present study are partly confirmative and partly hypothesis generating. |
| doi_str_mv | 10.3390/jpm10030087 |
| format | Article |
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Methods: A cross-sectional medical examination of subjects in Novosibirsk, Russia, was conducted after random sampling of the above age group. A total of 1457 subjects, 804 females and 653 males, were analyzed. The epidemiological diagnosis of IHD was made in accordance with 17 validated and functional criteria, employing exercise ECG for confirmation. Simultaneous quantitative analyses of 41 cytokines/chemokines in blood serum were performed by a multiplex assay using the HCYTMAG-60K-PX41 panel (MILLIPLEX MAP) on a Luminex 20 MAGPIX flow cytometer, with additional ELISA testing. Results: Flt3 ligand, GM-CSF, and MCP-1 were significantly associated with the relative risk of early IHD. In the presence of AO, GM-CSF, MCP-1 and IL-4 also significantly correlated with the relative risk of early IHD. By univariate regression analysis, the relative risk of early IHD was associated with lowered blood concentrations of Flt3 ligand, whereas the relative risk of early IHD in the presence of AO was associated with lowered blood concentrations of GM-CSF. Employing multivariable regression analysis, only lower blood levels of Flt3 ligand were associated with a relative risk of early IHD, whereas the relative risk of early IHD in the presence of AO was limited to lower levels of IL-4. Conclusion: Findings related to Flt3 ligand, GM-CSF, and IL-4 are consistent with the international literature. Results from the present study are partly confirmative and partly hypothesis generating.</description><identifier>ISSN: 2075-4426</identifier><identifier>EISSN: 2075-4426</identifier><identifier>DOI: 10.3390/jpm10030087</identifier><identifier>PMID: 32823638</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Adipocytes ; Age ; Angina pectoris ; Blood ; Blood levels ; Cardiovascular disease ; Chemokines ; Comorbidity ; Coronary artery disease ; Cytokines ; EKG ; Enzyme-linked immunosorbent assay ; Epidemiology ; FLT3L protein ; Granulocyte-macrophage colony-stimulating factor ; Granulocytes ; Growth factors ; Health aspects ; Heart diseases ; Inflammation ; Interleukin 4 ; Ischemia ; Ligands ; Monocyte chemoattractant protein 1 ; Myocardial ischemia ; Obesity ; Physiological aspects ; Population ; Precision medicine ; Proteins ; Questionnaires ; Regression analysis ; Statistical sampling ; Tumor necrosis factor-TNF ; Young adults</subject><ispartof>Journal of personalized medicine, 2020-09, Vol.10 (3), p.87</ispartof><rights>COPYRIGHT 2020 MDPI AG</rights><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-8e74cbbca16e674fc3d7180ffdd2d0b16ee96e0224f6aec212cddeef692132333</citedby><cites>FETCH-LOGICAL-c453t-8e74cbbca16e674fc3d7180ffdd2d0b16ee96e0224f6aec212cddeef692132333</cites><orcidid>0000-0002-4936-8362</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565846/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565846/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Ragino, Yulia I</creatorcontrib><creatorcontrib>Oblaukhova, Veronika I</creatorcontrib><creatorcontrib>Polonskaya, Yana V</creatorcontrib><creatorcontrib>Kuzminykh, Natalya A</creatorcontrib><creatorcontrib>Shcherbakova, Liliya V</creatorcontrib><creatorcontrib>Kashtanova, Elena V</creatorcontrib><title>The Blood Cytokine Profile of Young People with Early Ischemic Heart Disease Comorbid with Abdominal Obesity</title><title>Journal of personalized medicine</title><description>Objective: The aim was to study the blood cytokine/chemokine profile of 25–44-year-old people with early ischemic heart disease (IHD) comorbid with abdominal obesity (AO). Methods: A cross-sectional medical examination of subjects in Novosibirsk, Russia, was conducted after random sampling of the above age group. A total of 1457 subjects, 804 females and 653 males, were analyzed. The epidemiological diagnosis of IHD was made in accordance with 17 validated and functional criteria, employing exercise ECG for confirmation. Simultaneous quantitative analyses of 41 cytokines/chemokines in blood serum were performed by a multiplex assay using the HCYTMAG-60K-PX41 panel (MILLIPLEX MAP) on a Luminex 20 MAGPIX flow cytometer, with additional ELISA testing. Results: Flt3 ligand, GM-CSF, and MCP-1 were significantly associated with the relative risk of early IHD. In the presence of AO, GM-CSF, MCP-1 and IL-4 also significantly correlated with the relative risk of early IHD. By univariate regression analysis, the relative risk of early IHD was associated with lowered blood concentrations of Flt3 ligand, whereas the relative risk of early IHD in the presence of AO was associated with lowered blood concentrations of GM-CSF. Employing multivariable regression analysis, only lower blood levels of Flt3 ligand were associated with a relative risk of early IHD, whereas the relative risk of early IHD in the presence of AO was limited to lower levels of IL-4. Conclusion: Findings related to Flt3 ligand, GM-CSF, and IL-4 are consistent with the international literature. Results from the present study are partly confirmative and partly hypothesis generating.</description><subject>Adipocytes</subject><subject>Age</subject><subject>Angina pectoris</subject><subject>Blood</subject><subject>Blood levels</subject><subject>Cardiovascular disease</subject><subject>Chemokines</subject><subject>Comorbidity</subject><subject>Coronary artery disease</subject><subject>Cytokines</subject><subject>EKG</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Epidemiology</subject><subject>FLT3L protein</subject><subject>Granulocyte-macrophage colony-stimulating factor</subject><subject>Granulocytes</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Heart diseases</subject><subject>Inflammation</subject><subject>Interleukin 4</subject><subject>Ischemia</subject><subject>Ligands</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Myocardial ischemia</subject><subject>Obesity</subject><subject>Physiological aspects</subject><subject>Population</subject><subject>Precision medicine</subject><subject>Proteins</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Statistical sampling</subject><subject>Tumor necrosis factor-TNF</subject><subject>Young adults</subject><issn>2075-4426</issn><issn>2075-4426</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkk1PGzEQhq2qVUHAqX_AUi-VqlB_rXf3UilNKSAhwQEOPVlee5w49a5Te5cq_74OQQUqPAfb42fe0YwHoQ-UnHLeki_rTU8J4YQ09Rt0yEhdzYRg8u2z8wE6yXlNymoqxiR5jw44axiXvDlE4XYF-FuI0eLFdoy__AD4JkXnA-Do8M84DUt8A3FT7n_8uMJnOoUtvsxmBb03-AJ0GvF3n0FnwIvYx9R5u0fnnY29H3TA1x1kP26P0TunQ4aTx_0I3f04u11czK6uzy8X86uZERUfZw3UwnSd0VSCrIUz3Na0Ic5ZyyzpihdaCYQx4aQGwygz1gI42TLKGef8CH3d626mrgdrYBiTDmqTfK_TVkXt1cuXwa_UMt6rupJVI2QR-PQokOLvCfKoep8NhKAHiFNWTJTutZy0pKAf_0PXcUql6AdKtHVL2_qJWuoAyg8ulrxmJ6rmUlBS8ZK1UKevUMXsrtdxgN23vAz4vA8wKeacwP2rkRK1mw_1bD74X9AXq2U</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Ragino, Yulia I</creator><creator>Oblaukhova, Veronika I</creator><creator>Polonskaya, Yana V</creator><creator>Kuzminykh, Natalya A</creator><creator>Shcherbakova, Liliya V</creator><creator>Kashtanova, Elena V</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4936-8362</orcidid></search><sort><creationdate>20200901</creationdate><title>The Blood Cytokine Profile of Young People with Early Ischemic Heart Disease Comorbid with Abdominal Obesity</title><author>Ragino, Yulia I ; Oblaukhova, Veronika I ; Polonskaya, Yana V ; Kuzminykh, Natalya A ; Shcherbakova, Liliya V ; Kashtanova, Elena V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-8e74cbbca16e674fc3d7180ffdd2d0b16ee96e0224f6aec212cddeef692132333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adipocytes</topic><topic>Age</topic><topic>Angina pectoris</topic><topic>Blood</topic><topic>Blood levels</topic><topic>Cardiovascular disease</topic><topic>Chemokines</topic><topic>Comorbidity</topic><topic>Coronary artery disease</topic><topic>Cytokines</topic><topic>EKG</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Epidemiology</topic><topic>FLT3L protein</topic><topic>Granulocyte-macrophage colony-stimulating factor</topic><topic>Granulocytes</topic><topic>Growth factors</topic><topic>Health aspects</topic><topic>Heart diseases</topic><topic>Inflammation</topic><topic>Interleukin 4</topic><topic>Ischemia</topic><topic>Ligands</topic><topic>Monocyte chemoattractant protein 1</topic><topic>Myocardial ischemia</topic><topic>Obesity</topic><topic>Physiological aspects</topic><topic>Population</topic><topic>Precision medicine</topic><topic>Proteins</topic><topic>Questionnaires</topic><topic>Regression analysis</topic><topic>Statistical sampling</topic><topic>Tumor necrosis factor-TNF</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ragino, Yulia I</creatorcontrib><creatorcontrib>Oblaukhova, Veronika I</creatorcontrib><creatorcontrib>Polonskaya, Yana V</creatorcontrib><creatorcontrib>Kuzminykh, Natalya A</creatorcontrib><creatorcontrib>Shcherbakova, Liliya V</creatorcontrib><creatorcontrib>Kashtanova, Elena V</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of personalized medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ragino, Yulia I</au><au>Oblaukhova, Veronika I</au><au>Polonskaya, Yana V</au><au>Kuzminykh, Natalya A</au><au>Shcherbakova, Liliya V</au><au>Kashtanova, Elena V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Blood Cytokine Profile of Young People with Early Ischemic Heart Disease Comorbid with Abdominal Obesity</atitle><jtitle>Journal of personalized medicine</jtitle><date>2020-09-01</date><risdate>2020</risdate><volume>10</volume><issue>3</issue><spage>87</spage><pages>87-</pages><issn>2075-4426</issn><eissn>2075-4426</eissn><abstract>Objective: The aim was to study the blood cytokine/chemokine profile of 25–44-year-old people with early ischemic heart disease (IHD) comorbid with abdominal obesity (AO). Methods: A cross-sectional medical examination of subjects in Novosibirsk, Russia, was conducted after random sampling of the above age group. A total of 1457 subjects, 804 females and 653 males, were analyzed. The epidemiological diagnosis of IHD was made in accordance with 17 validated and functional criteria, employing exercise ECG for confirmation. Simultaneous quantitative analyses of 41 cytokines/chemokines in blood serum were performed by a multiplex assay using the HCYTMAG-60K-PX41 panel (MILLIPLEX MAP) on a Luminex 20 MAGPIX flow cytometer, with additional ELISA testing. Results: Flt3 ligand, GM-CSF, and MCP-1 were significantly associated with the relative risk of early IHD. In the presence of AO, GM-CSF, MCP-1 and IL-4 also significantly correlated with the relative risk of early IHD. By univariate regression analysis, the relative risk of early IHD was associated with lowered blood concentrations of Flt3 ligand, whereas the relative risk of early IHD in the presence of AO was associated with lowered blood concentrations of GM-CSF. Employing multivariable regression analysis, only lower blood levels of Flt3 ligand were associated with a relative risk of early IHD, whereas the relative risk of early IHD in the presence of AO was limited to lower levels of IL-4. Conclusion: Findings related to Flt3 ligand, GM-CSF, and IL-4 are consistent with the international literature. Results from the present study are partly confirmative and partly hypothesis generating.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>32823638</pmid><doi>10.3390/jpm10030087</doi><orcidid>https://orcid.org/0000-0002-4936-8362</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipocytes Age Angina pectoris Blood Blood levels Cardiovascular disease Chemokines Comorbidity Coronary artery disease Cytokines EKG Enzyme-linked immunosorbent assay Epidemiology FLT3L protein Granulocyte-macrophage colony-stimulating factor Granulocytes Growth factors Health aspects Heart diseases Inflammation Interleukin 4 Ischemia Ligands Monocyte chemoattractant protein 1 Myocardial ischemia Obesity Physiological aspects Population Precision medicine Proteins Questionnaires Regression analysis Statistical sampling Tumor necrosis factor-TNF Young adults |
| title | The Blood Cytokine Profile of Young People with Early Ischemic Heart Disease Comorbid with Abdominal Obesity |
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