mTOR-Dependent Role of Sestrin2 in Regulating Tumor Progression of Human Endometrial Cancer

Oncogenic activation of the mammalian target of rapamycin complex 1 (mTORC1) leads to endometrial cancer cell growth and proliferation. Sestrin2 (SESN2), a highly conserved stress-inducible protein, is involved in homeostatic regulation via inhibition of reactive oxygen species (ROS) and mTORC1. How...

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Veröffentlicht in:	Cancers 2020-09, Vol.12 (9), p.2515
Hauptverfasser:	Shin, Jiha, Bae, Jeongyun, Park, Sumi, Kang, Hyun-Goo, Shin, Seong Min, Won, Gunho, Kim, Jong-Seok, Cho, Ssang-Goo, Choi, Youngsok, Oh, Sang-Muk, Shin, Jongdae, Kim, Jeong Sig, Park, Hwan-Woo
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cell cycle Cell growth Cell migration Cell proliferation Development and progression Endometrial cancer Endometrium Gene expression Health aspects Hypoxia Kinases Liver cancer Mammals Medical prognosis Mesenchyme Metabolism Obesity Pathogenesis Phosphorylation Proteins Rapamycin Reactive oxygen species TOR protein Tumor cell lines Xenografts
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