Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma

Enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), the catalytic subunit of polycomb repressive complex 2 (PRC2), regulates genes involved in cell lineage and differentiation through methylating lysine 27 on histone H3 (H3K27me3). Recurrent gain-of-function mutations of EZH2 have been...

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Veröffentlicht in:	Cancers 2020-09, Vol.12 (9), p.2541
Hauptverfasser:	Park, Sungryul, Jo, Seung-Hyun, Kim, Jong-Hwan, Kim, Seon-Young, Ha, Jae Du, Hwang, Jong Yeon, Lee, Myeong Youl, Kang, Jong Soon, Han, Tae-Su, Park, Sung Goo, Kim, Sunhong, Park, Byoung Chul, Kim, Jeong-Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Apoptosis B cells B-cell lymphoma Cell differentiation Cell lineage Cyclin-dependent kinases Cytotoxicity Gene expression Genome-wide association studies Genomes Health aspects Histone H3 Ikaros protein Kinases Lymphocytes B Lymphoma Lymphomas Lysine Mutants Mutation Physiological aspects Polycomb group proteins Ribonucleic acid RNA Xenografts Zinc finger proteins
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