RhoA Mediates Epithelial Cell Shape Changes via Mechanosensitive Endocytosis

Epithelial remodeling involves ratcheting behavior whereby periodic contractility produces transient changes in cell-cell contact lengths, which stabilize to produce lasting morphogenetic changes. Pulsatile RhoA activity is thought to underlie morphogenetic ratchets, but how RhoA governs transient c...

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Veröffentlicht in:	Developmental cell 2020-01, Vol.52 (2), p.152-166.e5
Hauptverfasser:	Cavanaugh, Kate E., Staddon, Michael F., Munro, Edwin, Banerjee, Shiladitya, Gardel, Margaret L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adherens Junctions - physiology biophysics Cadherins - metabolism cell biology Cell Movement Cell Shape developmental biology Endocytosis Epithelial Cells - cytology Humans junction length junction remodeling Mechanotransduction, Cellular Morphogenesis ratcheting RhoA rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism
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