MiR-184 Combined with STC2 Promotes Endometrial Epithelial Cell Apoptosis in Dairy Goats via RAS/RAF/MEK/ERK Pathway
The endometrium undergoes a series of complex changes to form a receptive endometrium (RE) that allows the embryo to be implanted. The inability to establish endometrial receptivity of livestock causes embryo implantation failure and considerable losses to animal husbandry. MicroRNAs (miRNAs) are a...
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| Veröffentlicht in: | Genes 2020-09, Vol.11 (9), p.1052 |
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| creator | Cui, Jiuzeng Liu, Xiaorui Yang, Lichun Che, Sicheng Guo, Hongran Han, Jincheng Zhu, Zhongshi Cao, Binyun An, Xiaopeng Zhang, Lei Song, Yuxuan |
| description | The endometrium undergoes a series of complex changes to form a receptive endometrium (RE) that allows the embryo to be implanted. The inability to establish endometrial receptivity of livestock causes embryo implantation failure and considerable losses to animal husbandry. MicroRNAs (miRNAs) are a class of noncoding RNAs. Studies have found that miRNAs can regulate many critical physiological processes, including the establishment of RE during embryo implantation. miR-184 is highly expressed in the endometrial receptive period of dairy goats. This study aimed to explore the effect of miR-184 on endometrial epithelial cell (EEC) apoptosis and RE establishment. Stanniocalcin2 (STC2) is a direct target of miR-184, and miR-184 decreases the expression of STC2 in dairy goat EECs. miR-184 can activate EECs apoptosis through the RAS/RAF/MEK/ERK pathway. Additionally, miR-184 increases the expression levels of RE marker genes, such as forkhead box M1 (FOXM1) and vascular endothelial growth factor (VEGF). These findings indicate that miR-184 promotes the apoptosis of endometrial epithelial cells in dairy goats by downregulating STC2 via the RAS/RAF/MEK/ERK pathway, and that it may also regulate the establishment of RE in dairy goats. |
| doi_str_mv | 10.3390/genes11091052 |
| format | Article |
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The inability to establish endometrial receptivity of livestock causes embryo implantation failure and considerable losses to animal husbandry. MicroRNAs (miRNAs) are a class of noncoding RNAs. Studies have found that miRNAs can regulate many critical physiological processes, including the establishment of RE during embryo implantation. miR-184 is highly expressed in the endometrial receptive period of dairy goats. This study aimed to explore the effect of miR-184 on endometrial epithelial cell (EEC) apoptosis and RE establishment. Stanniocalcin2 (STC2) is a direct target of miR-184, and miR-184 decreases the expression of STC2 in dairy goat EECs. miR-184 can activate EECs apoptosis through the RAS/RAF/MEK/ERK pathway. Additionally, miR-184 increases the expression levels of RE marker genes, such as forkhead box M1 (FOXM1) and vascular endothelial growth factor (VEGF). These findings indicate that miR-184 promotes the apoptosis of endometrial epithelial cells in dairy goats by downregulating STC2 via the RAS/RAF/MEK/ERK pathway, and that it may also regulate the establishment of RE in dairy goats.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes11091052</identifier><identifier>PMID: 32906580</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animal husbandry ; Animals ; Apoptosis ; Binding sites ; Cell cycle ; Cell growth ; Cloning ; Endometrium ; Endometrium - metabolism ; Endometrium - pathology ; Enzymes ; Epithelial cells ; Epithelial Cells - metabolism ; Epithelial Cells - pathology ; Experiments ; Extracellular signal-regulated kinase ; Female ; Forkhead protein ; Gene expression ; Gene Expression Regulation ; Genetic aspects ; Glycoproteins - genetics ; Glycoproteins - metabolism ; Goats ; Health aspects ; Liver cancer ; Livestock ; Mammals ; MAP Kinase Signaling System ; Metabolic pathways ; MicroRNA ; MicroRNAs - genetics ; miRNA ; Physiological aspects ; Pregnancy ; Proteins ; raf Kinases - genetics ; raf Kinases - metabolism ; ras Proteins - genetics ; ras Proteins - metabolism ; Vascular endothelial growth factor</subject><ispartof>Genes, 2020-09, Vol.11 (9), p.1052</ispartof><rights>COPYRIGHT 2020 MDPI AG</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-9a984211e245e381c4b4a0e00b2a37b51c51bf3f494178fed12ddef047d1c3143</citedby><cites>FETCH-LOGICAL-c443t-9a984211e245e381c4b4a0e00b2a37b51c51bf3f494178fed12ddef047d1c3143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565287/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565287/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32906580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cui, Jiuzeng</creatorcontrib><creatorcontrib>Liu, Xiaorui</creatorcontrib><creatorcontrib>Yang, Lichun</creatorcontrib><creatorcontrib>Che, Sicheng</creatorcontrib><creatorcontrib>Guo, Hongran</creatorcontrib><creatorcontrib>Han, Jincheng</creatorcontrib><creatorcontrib>Zhu, Zhongshi</creatorcontrib><creatorcontrib>Cao, Binyun</creatorcontrib><creatorcontrib>An, Xiaopeng</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Song, Yuxuan</creatorcontrib><title>MiR-184 Combined with STC2 Promotes Endometrial Epithelial Cell Apoptosis in Dairy Goats via RAS/RAF/MEK/ERK Pathway</title><title>Genes</title><addtitle>Genes (Basel)</addtitle><description>The endometrium undergoes a series of complex changes to form a receptive endometrium (RE) that allows the embryo to be implanted. The inability to establish endometrial receptivity of livestock causes embryo implantation failure and considerable losses to animal husbandry. MicroRNAs (miRNAs) are a class of noncoding RNAs. Studies have found that miRNAs can regulate many critical physiological processes, including the establishment of RE during embryo implantation. miR-184 is highly expressed in the endometrial receptive period of dairy goats. This study aimed to explore the effect of miR-184 on endometrial epithelial cell (EEC) apoptosis and RE establishment. Stanniocalcin2 (STC2) is a direct target of miR-184, and miR-184 decreases the expression of STC2 in dairy goat EECs. miR-184 can activate EECs apoptosis through the RAS/RAF/MEK/ERK pathway. Additionally, miR-184 increases the expression levels of RE marker genes, such as forkhead box M1 (FOXM1) and vascular endothelial growth factor (VEGF). These findings indicate that miR-184 promotes the apoptosis of endometrial epithelial cells in dairy goats by downregulating STC2 via the RAS/RAF/MEK/ERK pathway, and that it may also regulate the establishment of RE in dairy goats.</description><subject>Animal husbandry</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Binding sites</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Cloning</subject><subject>Endometrium</subject><subject>Endometrium - metabolism</subject><subject>Endometrium - pathology</subject><subject>Enzymes</subject><subject>Epithelial cells</subject><subject>Epithelial Cells - metabolism</subject><subject>Epithelial Cells - pathology</subject><subject>Experiments</subject><subject>Extracellular signal-regulated kinase</subject><subject>Female</subject><subject>Forkhead protein</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Genetic aspects</subject><subject>Glycoproteins - genetics</subject><subject>Glycoproteins - metabolism</subject><subject>Goats</subject><subject>Health aspects</subject><subject>Liver cancer</subject><subject>Livestock</subject><subject>Mammals</subject><subject>MAP Kinase Signaling System</subject><subject>Metabolic pathways</subject><subject>MicroRNA</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Physiological aspects</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>raf Kinases - genetics</subject><subject>raf Kinases - metabolism</subject><subject>ras Proteins - genetics</subject><subject>ras Proteins - metabolism</subject><subject>Vascular endothelial growth factor</subject><issn>2073-4425</issn><issn>2073-4425</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkc1P3DAQxaOqVUGUY6-VpV56Sdcf43xcKkXbQBGgooWeLSeZ7BolcWp7Qfvf1wuUQn2Zkean53nzkuQjo1-FKOlijRN6xmjJqORvkkNOc5ECcPn2RX-QHHt_S-MDyimV75MDwUuayYIeJuHSrFJWAFnasTETduTehA25vllycuXsaAN6Uk-dHTE4owdSz3GOw75d4jCQarZzsN54YibyXRu3I6dWB0_ujCar6nqxqk4Wl_X5ol6dkysdNvd69yF51-vB4_FTPUp-ndQ3yx_pxc_Ts2V1kbYAIqSlLgvgjCEHiaJgLTSgKVLacC3yRrJWsqYXPZTA8qLHjvGuw55C3rFWMBBHybdH3XnbjNi1OAWnBzU7M2q3U1Yb9XoymY1a2zuVy0zyIo8CX54EnP29RR_UaHwbbesJ7dYrDsCyeHqgEf38H3prt26K9h6oopQg2D9qrQdUZupt_Lfdi6oqAyYyWsoiUukj1TrrvcP-eWVG1T549Sr4yH966fOZ_huz-AMzeaYW</recordid><startdate>20200907</startdate><enddate>20200907</enddate><creator>Cui, Jiuzeng</creator><creator>Liu, Xiaorui</creator><creator>Yang, Lichun</creator><creator>Che, Sicheng</creator><creator>Guo, Hongran</creator><creator>Han, Jincheng</creator><creator>Zhu, Zhongshi</creator><creator>Cao, Binyun</creator><creator>An, Xiaopeng</creator><creator>Zhang, Lei</creator><creator>Song, Yuxuan</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200907</creationdate><title>MiR-184 Combined with STC2 Promotes Endometrial Epithelial Cell Apoptosis in Dairy Goats via RAS/RAF/MEK/ERK Pathway</title><author>Cui, Jiuzeng ; 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The inability to establish endometrial receptivity of livestock causes embryo implantation failure and considerable losses to animal husbandry. MicroRNAs (miRNAs) are a class of noncoding RNAs. Studies have found that miRNAs can regulate many critical physiological processes, including the establishment of RE during embryo implantation. miR-184 is highly expressed in the endometrial receptive period of dairy goats. This study aimed to explore the effect of miR-184 on endometrial epithelial cell (EEC) apoptosis and RE establishment. Stanniocalcin2 (STC2) is a direct target of miR-184, and miR-184 decreases the expression of STC2 in dairy goat EECs. miR-184 can activate EECs apoptosis through the RAS/RAF/MEK/ERK pathway. Additionally, miR-184 increases the expression levels of RE marker genes, such as forkhead box M1 (FOXM1) and vascular endothelial growth factor (VEGF). These findings indicate that miR-184 promotes the apoptosis of endometrial epithelial cells in dairy goats by downregulating STC2 via the RAS/RAF/MEK/ERK pathway, and that it may also regulate the establishment of RE in dairy goats.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32906580</pmid><doi>10.3390/genes11091052</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Animal husbandry Animals Apoptosis Binding sites Cell cycle Cell growth Cloning Endometrium Endometrium - metabolism Endometrium - pathology Enzymes Epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Experiments Extracellular signal-regulated kinase Female Forkhead protein Gene expression Gene Expression Regulation Genetic aspects Glycoproteins - genetics Glycoproteins - metabolism Goats Health aspects Liver cancer Livestock Mammals MAP Kinase Signaling System Metabolic pathways MicroRNA MicroRNAs - genetics miRNA Physiological aspects Pregnancy Proteins raf Kinases - genetics raf Kinases - metabolism ras Proteins - genetics ras Proteins - metabolism Vascular endothelial growth factor |
| title | MiR-184 Combined with STC2 Promotes Endometrial Epithelial Cell Apoptosis in Dairy Goats via RAS/RAF/MEK/ERK Pathway |
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