MicroRNAs Regulate Intestinal Immunity and Gut Microbiota for Gastrointestinal Health: A Comprehensive Review
MicroRNAs are small non-coding RNAs regulating gene expression at the post-transcriptional level. The regulation of microRNA expression in the gut intestine is gradually recognized as one of the crucial contributors of intestinal homeostasis and overall health. Recent studies indicated that both the...
Gespeichert in:
| Veröffentlicht in: | Genes 2020-09, Vol.11 (9), p.1075 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 9 |
| container_start_page | 1075 |
| container_title | Genes |
| container_volume | 11 |
| creator | Bi, Kefan Zhang, Xujun Chen, Wenbiao Diao, Hongyan |
| description | MicroRNAs are small non-coding RNAs regulating gene expression at the post-transcriptional level. The regulation of microRNA expression in the gut intestine is gradually recognized as one of the crucial contributors of intestinal homeostasis and overall health. Recent studies indicated that both the microRNAs endogenous in the gut intestine and exogenous from diets could play influential roles in modulating microbial colonization and intestinal immunity. In this review, we discuss the biological functions of microRNAs in regulating intestinal homeostasis by modulating intestinal immune responses and gut microbiota. We particularly focus on addressing the microRNA-dependent communication and interactions among microRNA, gut microbiota, and intestinal immune system. Besides, we also summarize the roles of diet-derived microRNAs in host-microbiome homeostasis and their benefits on intestinal health. A better understanding of the relationships among intestinal disorders, microRNAs, and other factors influencing intestinal health can facilitate the application of microRNA-based therapeutics for gastrointestinal diseases. |
| doi_str_mv | 10.3390/genes11091075 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7564790</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A641360981</galeid><sourcerecordid>A641360981</sourcerecordid><originalsourceid>FETCH-LOGICAL-c509t-9527d751d76c0bb5cda072f1fd82d0337a2944fa2194515569e760457bec70593</originalsourceid><addsrcrecordid>eNpdkUtrGzEURkVpaUKSZbdF0E03k-o5srooGNM6hqSBkK6FZuaOrTAjuZLGJf--cpzmUW0k0NG5uvdD6AMl55xr8mUNHhKlRFOi5Bt0zIjilRBMvn1xPkJnKd2RsgRhhMj36IgzzZmi9TEar1wbw83PecI3sJ4GmwGvfIaUnbcDXo3j5F2-x9Z3eDll_IA3LmSL-xDx0qYcg3t-cAF2yJuveI4XYdxG2IBPbgdFvnPw5xS96-2Q4OxxP0G_fny_XVxUl9fL1WJ-WbWS6FxpyVSnJO1U3ZKmkW1niWI97bsZ6wjnyjItRG8Z1UJSKWsNqiZCqgZaRaTmJ-jbwbudmhG6FnyOdjDb6EYb702wzry-8W5j1mFnlKyF0qQIPj8KYvg9lebM6FILw2A9hCkZJgSXjNaCFvTTf-hdmGKZxYGqxUzR2TO1tgMY5_tQ6rZ7qZnvLTXRs72rOlBlyClF6J--TInZJ25eJV74jy_7fKL_5cv_AhN8pmk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2443648718</pqid></control><display><type>article</type><title>MicroRNAs Regulate Intestinal Immunity and Gut Microbiota for Gastrointestinal Health: A Comprehensive Review</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Bi, Kefan ; Zhang, Xujun ; Chen, Wenbiao ; Diao, Hongyan</creator><creatorcontrib>Bi, Kefan ; Zhang, Xujun ; Chen, Wenbiao ; Diao, Hongyan</creatorcontrib><description>MicroRNAs are small non-coding RNAs regulating gene expression at the post-transcriptional level. The regulation of microRNA expression in the gut intestine is gradually recognized as one of the crucial contributors of intestinal homeostasis and overall health. Recent studies indicated that both the microRNAs endogenous in the gut intestine and exogenous from diets could play influential roles in modulating microbial colonization and intestinal immunity. In this review, we discuss the biological functions of microRNAs in regulating intestinal homeostasis by modulating intestinal immune responses and gut microbiota. We particularly focus on addressing the microRNA-dependent communication and interactions among microRNA, gut microbiota, and intestinal immune system. Besides, we also summarize the roles of diet-derived microRNAs in host-microbiome homeostasis and their benefits on intestinal health. A better understanding of the relationships among intestinal disorders, microRNAs, and other factors influencing intestinal health can facilitate the application of microRNA-based therapeutics for gastrointestinal diseases.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes11091075</identifier><identifier>PMID: 32932716</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Biomarkers ; Colonization ; Cytokines ; Dendritic cells ; Diet ; Digestive system ; Gastrointestinal diseases ; Gastrointestinal Diseases - genetics ; Gastrointestinal Diseases - immunology ; Gastrointestinal Diseases - pathology ; Gastrointestinal Microbiome - genetics ; Gastrointestinal Microbiome - immunology ; Gastrointestinal tract ; Gastrointestinal Tract - immunology ; Gastrointestinal Tract - metabolism ; Gastrointestinal Tract - pathology ; Gene expression ; Gene regulation ; Genetic aspects ; Genetic regulation ; Homeostasis ; Humans ; Immune response ; Immune system ; Immunity, Innate - immunology ; Infections ; Inflammatory bowel disease ; Intestinal microflora ; Intestine ; Intestines ; Intestines - immunology ; Microbiomes ; Microbiota ; Microbiota (Symbiotic organisms) ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; miRNA ; Non-coding RNA ; Observations ; Pathogenesis ; Pathogens ; Physiological aspects ; Post-transcription ; Review ; RNA polymerase ; Roles</subject><ispartof>Genes, 2020-09, Vol.11 (9), p.1075</ispartof><rights>COPYRIGHT 2020 MDPI AG</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-9527d751d76c0bb5cda072f1fd82d0337a2944fa2194515569e760457bec70593</citedby><cites>FETCH-LOGICAL-c509t-9527d751d76c0bb5cda072f1fd82d0337a2944fa2194515569e760457bec70593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564790/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564790/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32932716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bi, Kefan</creatorcontrib><creatorcontrib>Zhang, Xujun</creatorcontrib><creatorcontrib>Chen, Wenbiao</creatorcontrib><creatorcontrib>Diao, Hongyan</creatorcontrib><title>MicroRNAs Regulate Intestinal Immunity and Gut Microbiota for Gastrointestinal Health: A Comprehensive Review</title><title>Genes</title><addtitle>Genes (Basel)</addtitle><description>MicroRNAs are small non-coding RNAs regulating gene expression at the post-transcriptional level. The regulation of microRNA expression in the gut intestine is gradually recognized as one of the crucial contributors of intestinal homeostasis and overall health. Recent studies indicated that both the microRNAs endogenous in the gut intestine and exogenous from diets could play influential roles in modulating microbial colonization and intestinal immunity. In this review, we discuss the biological functions of microRNAs in regulating intestinal homeostasis by modulating intestinal immune responses and gut microbiota. We particularly focus on addressing the microRNA-dependent communication and interactions among microRNA, gut microbiota, and intestinal immune system. Besides, we also summarize the roles of diet-derived microRNAs in host-microbiome homeostasis and their benefits on intestinal health. A better understanding of the relationships among intestinal disorders, microRNAs, and other factors influencing intestinal health can facilitate the application of microRNA-based therapeutics for gastrointestinal diseases.</description><subject>Animals</subject><subject>Biomarkers</subject><subject>Colonization</subject><subject>Cytokines</subject><subject>Dendritic cells</subject><subject>Diet</subject><subject>Digestive system</subject><subject>Gastrointestinal diseases</subject><subject>Gastrointestinal Diseases - genetics</subject><subject>Gastrointestinal Diseases - immunology</subject><subject>Gastrointestinal Diseases - pathology</subject><subject>Gastrointestinal Microbiome - genetics</subject><subject>Gastrointestinal Microbiome - immunology</subject><subject>Gastrointestinal tract</subject><subject>Gastrointestinal Tract - immunology</subject><subject>Gastrointestinal Tract - metabolism</subject><subject>Gastrointestinal Tract - pathology</subject><subject>Gene expression</subject><subject>Gene regulation</subject><subject>Genetic aspects</subject><subject>Genetic regulation</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity, Innate - immunology</subject><subject>Infections</subject><subject>Inflammatory bowel disease</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Intestines</subject><subject>Intestines - immunology</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Non-coding RNA</subject><subject>Observations</subject><subject>Pathogenesis</subject><subject>Pathogens</subject><subject>Physiological aspects</subject><subject>Post-transcription</subject><subject>Review</subject><subject>RNA polymerase</subject><subject>Roles</subject><issn>2073-4425</issn><issn>2073-4425</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkUtrGzEURkVpaUKSZbdF0E03k-o5srooGNM6hqSBkK6FZuaOrTAjuZLGJf--cpzmUW0k0NG5uvdD6AMl55xr8mUNHhKlRFOi5Bt0zIjilRBMvn1xPkJnKd2RsgRhhMj36IgzzZmi9TEar1wbw83PecI3sJ4GmwGvfIaUnbcDXo3j5F2-x9Z3eDll_IA3LmSL-xDx0qYcg3t-cAF2yJuveI4XYdxG2IBPbgdFvnPw5xS96-2Q4OxxP0G_fny_XVxUl9fL1WJ-WbWS6FxpyVSnJO1U3ZKmkW1niWI97bsZ6wjnyjItRG8Z1UJSKWsNqiZCqgZaRaTmJ-jbwbudmhG6FnyOdjDb6EYb702wzry-8W5j1mFnlKyF0qQIPj8KYvg9lebM6FILw2A9hCkZJgSXjNaCFvTTf-hdmGKZxYGqxUzR2TO1tgMY5_tQ6rZ7qZnvLTXRs72rOlBlyClF6J--TInZJ25eJV74jy_7fKL_5cv_AhN8pmk</recordid><startdate>20200912</startdate><enddate>20200912</enddate><creator>Bi, Kefan</creator><creator>Zhang, Xujun</creator><creator>Chen, Wenbiao</creator><creator>Diao, Hongyan</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200912</creationdate><title>MicroRNAs Regulate Intestinal Immunity and Gut Microbiota for Gastrointestinal Health: A Comprehensive Review</title><author>Bi, Kefan ; Zhang, Xujun ; Chen, Wenbiao ; Diao, Hongyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-9527d751d76c0bb5cda072f1fd82d0337a2944fa2194515569e760457bec70593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Biomarkers</topic><topic>Colonization</topic><topic>Cytokines</topic><topic>Dendritic cells</topic><topic>Diet</topic><topic>Digestive system</topic><topic>Gastrointestinal diseases</topic><topic>Gastrointestinal Diseases - genetics</topic><topic>Gastrointestinal Diseases - immunology</topic><topic>Gastrointestinal Diseases - pathology</topic><topic>Gastrointestinal Microbiome - genetics</topic><topic>Gastrointestinal Microbiome - immunology</topic><topic>Gastrointestinal tract</topic><topic>Gastrointestinal Tract - immunology</topic><topic>Gastrointestinal Tract - metabolism</topic><topic>Gastrointestinal Tract - pathology</topic><topic>Gene expression</topic><topic>Gene regulation</topic><topic>Genetic aspects</topic><topic>Genetic regulation</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity, Innate - immunology</topic><topic>Infections</topic><topic>Inflammatory bowel disease</topic><topic>Intestinal microflora</topic><topic>Intestine</topic><topic>Intestines</topic><topic>Intestines - immunology</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>miRNA</topic><topic>Non-coding RNA</topic><topic>Observations</topic><topic>Pathogenesis</topic><topic>Pathogens</topic><topic>Physiological aspects</topic><topic>Post-transcription</topic><topic>Review</topic><topic>RNA polymerase</topic><topic>Roles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bi, Kefan</creatorcontrib><creatorcontrib>Zhang, Xujun</creatorcontrib><creatorcontrib>Chen, Wenbiao</creatorcontrib><creatorcontrib>Diao, Hongyan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bi, Kefan</au><au>Zhang, Xujun</au><au>Chen, Wenbiao</au><au>Diao, Hongyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNAs Regulate Intestinal Immunity and Gut Microbiota for Gastrointestinal Health: A Comprehensive Review</atitle><jtitle>Genes</jtitle><addtitle>Genes (Basel)</addtitle><date>2020-09-12</date><risdate>2020</risdate><volume>11</volume><issue>9</issue><spage>1075</spage><pages>1075-</pages><issn>2073-4425</issn><eissn>2073-4425</eissn><abstract>MicroRNAs are small non-coding RNAs regulating gene expression at the post-transcriptional level. The regulation of microRNA expression in the gut intestine is gradually recognized as one of the crucial contributors of intestinal homeostasis and overall health. Recent studies indicated that both the microRNAs endogenous in the gut intestine and exogenous from diets could play influential roles in modulating microbial colonization and intestinal immunity. In this review, we discuss the biological functions of microRNAs in regulating intestinal homeostasis by modulating intestinal immune responses and gut microbiota. We particularly focus on addressing the microRNA-dependent communication and interactions among microRNA, gut microbiota, and intestinal immune system. Besides, we also summarize the roles of diet-derived microRNAs in host-microbiome homeostasis and their benefits on intestinal health. A better understanding of the relationships among intestinal disorders, microRNAs, and other factors influencing intestinal health can facilitate the application of microRNA-based therapeutics for gastrointestinal diseases.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32932716</pmid><doi>10.3390/genes11091075</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2073-4425 |
| ispartof | Genes, 2020-09, Vol.11 (9), p.1075 |
| issn | 2073-4425 2073-4425 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7564790 |
| source | MEDLINE; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Biomarkers Colonization Cytokines Dendritic cells Diet Digestive system Gastrointestinal diseases Gastrointestinal Diseases - genetics Gastrointestinal Diseases - immunology Gastrointestinal Diseases - pathology Gastrointestinal Microbiome - genetics Gastrointestinal Microbiome - immunology Gastrointestinal tract Gastrointestinal Tract - immunology Gastrointestinal Tract - metabolism Gastrointestinal Tract - pathology Gene expression Gene regulation Genetic aspects Genetic regulation Homeostasis Humans Immune response Immune system Immunity, Innate - immunology Infections Inflammatory bowel disease Intestinal microflora Intestine Intestines Intestines - immunology Microbiomes Microbiota Microbiota (Symbiotic organisms) MicroRNA MicroRNAs MicroRNAs - genetics miRNA Non-coding RNA Observations Pathogenesis Pathogens Physiological aspects Post-transcription Review RNA polymerase Roles |
| title | MicroRNAs Regulate Intestinal Immunity and Gut Microbiota for Gastrointestinal Health: A Comprehensive Review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T07%3A46%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=MicroRNAs%20Regulate%20Intestinal%20Immunity%20and%20Gut%20Microbiota%20for%20Gastrointestinal%20Health:%20A%20Comprehensive%20Review&rft.jtitle=Genes&rft.au=Bi,%20Kefan&rft.date=2020-09-12&rft.volume=11&rft.issue=9&rft.spage=1075&rft.pages=1075-&rft.issn=2073-4425&rft.eissn=2073-4425&rft_id=info:doi/10.3390/genes11091075&rft_dat=%3Cgale_pubme%3EA641360981%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2443648718&rft_id=info:pmid/32932716&rft_galeid=A641360981&rfr_iscdi=true |