Breast Tumor Cell Invasion and Pro-Invasive Activity of Cancer-Associated Fibroblasts Co-Targeted by Novel Urokinase-Derived Decapeptides

Among peritumoral cells, cancer-associated fibroblasts (CAFs) are major facilitators of tumor progression. This study describes the effects of two urokinase-derived, novel decapeptides, denoted as Pep 1 and its cyclic derivative Pep 2. In a mouse model of tumor dissemination, using HT1080 fibrosarco...

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Veröffentlicht in:	Cancers 2020-09, Vol.12 (9), p.2404
Hauptverfasser:	Belli, Stefania, Franco, Paola, Iommelli, Francesca, De Vincenzo, Anna, Brancaccio, Diego, Telesca, Marialucia, Merlino, Francesco, Novellino, Ettore, Ranson, Marie, Del Vecchio, Silvana, Grieco, Paolo, Carotenuto, Alfonso, Stoppelli, Maria Patrizia
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Brain tumors Breast cancer Breast carcinoma Carcinoma Collagen Fibroblasts Fibrosarcoma Health aspects Insulin-like growth factors Invasiveness Lungs Mammary gland Metastases Metastasis NMR Nuclear magnetic resonance Peptides Phenotypes Smooth muscle Telomerase Tumors U-Plasminogen activator Vitronectin
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