Modifications of Titin Contribute to the Progression of Cardiomyopathy and Represent a Therapeutic Target for Treatment of Heart Failure

Titin is the largest human protein and an essential component of the cardiac sarcomere. With multiple immunoglobulin(Ig)-like domains that serve as molecular springs, titin contributes significantly to the passive tension, systolic function, and diastolic function of the heart. Mutations leading to...

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Veröffentlicht in:	Journal of clinical medicine 2020-08, Vol.9 (9), p.2770
Hauptverfasser:	Tharp, Charles, Mestroni, Luisa, Taylor, Matthew
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Blood Cardiac function Cardiomyocytes Cardiomyopathy Clinical medicine Genotype & phenotype Heart failure Mutation Physiology Proteins Review Stroke
Online-Zugang:	Volltext
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