A parallel-group, multicenter randomized, double-blinded, placebo-controlled, phase 2/3, clinical trial to test the efficacy of pyridostigmine bromide at low doses to reduce mortality or invasive mechanical ventilation in adults with severe SARS-CoV-2 infection: the Pyridostigmine In Severe COvid-19 (PISCO) trial protocol

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the causative agent of coronavirus disease 2019 (COVID-19), may lead to severe systemic inflammatory response, pulmonary damage, and even acute respiratory distress syndrome (ARDS). This in turn may result in respiratory failure...

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Veröffentlicht in:	BMC infectious diseases 2020-10, Vol.20 (1), p.765-765, Article 765
Hauptverfasser:	Fragoso-Saavedra, Sergio, Iruegas-Nunez, David A, Quintero-Villegas, Alejandro, García-González, H Benjamín, Nuñez, Isaac, Carbajal-Morelos, Sergio L, Audelo-Cruz, Belem M, Arias-Martínez, Sarahi, Caro-Vega, Yanink, Calva, Juan José, Luqueño-Martínez, Verónica, González-Duarte, Alejandra, Crabtree-Ramírez, Brenda, Crispín, José C, Sierra-Madero, Juan, Belaunzarán-Zamudio, Pablo F, Valdés-Ferrer, Sergio I
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Adult Adult respiratory distress syndrome Adults Betacoronavirus - pathogenicity Bone disorder agents Bromine compounds Cholinesterase Inhibitors - therapeutic use Clinical trials Coronaviridae Coronavirus Infections - drug therapy Coronavirus Infections - mortality Coronavirus Infections - pathology Coronavirus Infections - physiopathology Coronaviruses COVID-19 Esterase Fatalities HIV Hospitalization Human immunodeficiency virus Humans Immunomodulation Infection Infections Infectious diseases Inflammation Inflammatory diseases Inflammatory response Intervention Invasive mechanical ventilation Lung - drug effects Lung - pathology Lung - physiopathology Mechanical ventilation Mimicry Mortality Pandemics Pneumonia, Viral - drug therapy Pneumonia, Viral - mortality Pneumonia, Viral - pathology Pneumonia, Viral - physiopathology Product development Pyridostigmine Pyridostigmine bromide Pyridostigmine Bromide - therapeutic use Respiration, Artificial Respiratory diseases Respiratory distress syndrome Respiratory failure SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Study Protocol Ventilation Ventilators Viral diseases
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