A Systematic Review of COVID-19 Infection in Kidney Transplant Recipients: A Universal Effort to Preserve Patients' Lives and Allografts
The coronavirus disease 2019 (COVID-19) pandemic has posed a significant challenge to physicians and healthcare systems worldwide. Evidence about kidney transplant (KTx) recipients is still limited. A systematic literature review was performed. We included 63 articles published from 1 January until...
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| Veröffentlicht in: | Journal of clinical medicine 2020-09, Vol.9 (9), p.2986 |
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| creator | Marinaki, Smaragdi Tsiakas, Stathis Korogiannou, Maria Grigorakos, Konstantinos Papalois, Vassilios Boletis, Ioannis |
| description | The coronavirus disease 2019 (COVID-19) pandemic has posed a significant challenge to physicians and healthcare systems worldwide. Evidence about kidney transplant (KTx) recipients is still limited. A systematic literature review was performed. We included 63 articles published from 1 January until 7 July 2020, reporting on 420 adult KTx recipients with confirmed COVID-19. The mean age of patients was 55 ± 15 years. There was a male predominance (67%). The majority (74%) were deceased donor recipients, and 23% were recently transplanted ( |
| doi_str_mv | 10.3390/jcm9092986 |
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Evidence about kidney transplant (KTx) recipients is still limited. A systematic literature review was performed. We included 63 articles published from 1 January until 7 July 2020, reporting on 420 adult KTx recipients with confirmed COVID-19. The mean age of patients was 55 ± 15 years. There was a male predominance (67%). The majority (74%) were deceased donor recipients, and 23% were recently transplanted (<1 year). Most patients (88%) had at least one comorbidity, 29% had two, and 18% three. Ninety-three percent of cases were hospitalized. Among them, 30% were admitted to the intensive care unit, 45% developed acute respiratory distress syndrome, and 44% had acute kidney injury with 23% needing renal replacement therapy. From the hospitalized patients a total of 22% died, 59% were discharged, and 19% were still in hospital at the time of publication. Immunosuppression was reduced in 27%, discontinued in 31%, and remained unchanged in 5%. Hydroxychloroquine was administered to 78% of patients, antibiotics to 73%, and antivirals to 30% while 25% received corticosteroid boluses, 28% received anti-interleukin agents, and 8% were given immunoglobulin. The main finding of our analysis was that the incidence of COVID-19 among kidney transplant patients is not particularly high, but when they do get infected, this is related to significant morbidity and mortality.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm9092986</identifier><identifier>PMID: 32947798</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Chronic obstructive pulmonary disease ; Clinical medicine ; Clinical outcomes ; Coronaviruses ; COVID-19 ; Creatinine ; Cytokines ; Fatalities ; Hepatitis ; Hospitalization ; Infections ; Kidney transplants ; Patients ; Review ; Severe acute respiratory syndrome coronavirus 2 ; Systematic review ; Viral infections</subject><ispartof>Journal of clinical medicine, 2020-09, Vol.9 (9), p.2986</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). 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Evidence about kidney transplant (KTx) recipients is still limited. A systematic literature review was performed. We included 63 articles published from 1 January until 7 July 2020, reporting on 420 adult KTx recipients with confirmed COVID-19. The mean age of patients was 55 ± 15 years. There was a male predominance (67%). The majority (74%) were deceased donor recipients, and 23% were recently transplanted (<1 year). Most patients (88%) had at least one comorbidity, 29% had two, and 18% three. Ninety-three percent of cases were hospitalized. Among them, 30% were admitted to the intensive care unit, 45% developed acute respiratory distress syndrome, and 44% had acute kidney injury with 23% needing renal replacement therapy. From the hospitalized patients a total of 22% died, 59% were discharged, and 19% were still in hospital at the time of publication. Immunosuppression was reduced in 27%, discontinued in 31%, and remained unchanged in 5%. Hydroxychloroquine was administered to 78% of patients, antibiotics to 73%, and antivirals to 30% while 25% received corticosteroid boluses, 28% received anti-interleukin agents, and 8% were given immunoglobulin. The main finding of our analysis was that the incidence of COVID-19 among kidney transplant patients is not particularly high, but when they do get infected, this is related to significant morbidity and mortality.</description><subject>Chronic obstructive pulmonary disease</subject><subject>Clinical medicine</subject><subject>Clinical outcomes</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Creatinine</subject><subject>Cytokines</subject><subject>Fatalities</subject><subject>Hepatitis</subject><subject>Hospitalization</subject><subject>Infections</subject><subject>Kidney transplants</subject><subject>Patients</subject><subject>Review</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Systematic review</subject><subject>Viral infections</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkd9qFDEUxgex2NL2xgeQgBcWYTT_J_FCWLZVFxdatPU2ZDJJzTKTrEl2Zd-gj92U1lrNTQLnl-9853xN8xLBd4RI-H5lJgklloI_aw4w7LoWEkGeP3nvN8c5r2A9QlCMuhfNPsGSdp0UB83NDHzf5WInXbwB3-zW298gOjA__7E4bZEEi-CsKT4G4AP46odgd-Ay6ZDXow6l_jB-7W0o-QOYgavgtzZlPYIz52IqoERwkWy2aWvBRW1xB74By0ploMMAZuMYr5N2JR81e06P2R4_3IfN1aezy_mXdnn-eTGfLVtDIS8tc_0g2IB051hnuWA9NbTXlNMBU000Mlw4Z-SgLR94b2sVMkEgdMxgNmBy2Hy8111v-skOpjpKelTr5Ceddipqr_6tBP9TXcet6hgnjMkqcPIgkOKvjc1FTT4bO9Z12LjJClNKieCEooq-_g9dxU0KdTyFOUWISoxopd7eUybFnJN1j2YQVHcZq78ZV_jVU_uP6J9EyS1-5qMa</recordid><startdate>20200916</startdate><enddate>20200916</enddate><creator>Marinaki, Smaragdi</creator><creator>Tsiakas, Stathis</creator><creator>Korogiannou, Maria</creator><creator>Grigorakos, Konstantinos</creator><creator>Papalois, Vassilios</creator><creator>Boletis, Ioannis</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200916</creationdate><title>A Systematic Review of COVID-19 Infection in Kidney Transplant Recipients: A Universal Effort to Preserve Patients' Lives and Allografts</title><author>Marinaki, Smaragdi ; 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| source | MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Chronic obstructive pulmonary disease Clinical medicine Clinical outcomes Coronaviruses COVID-19 Creatinine Cytokines Fatalities Hepatitis Hospitalization Infections Kidney transplants Patients Review Severe acute respiratory syndrome coronavirus 2 Systematic review Viral infections |
| title | A Systematic Review of COVID-19 Infection in Kidney Transplant Recipients: A Universal Effort to Preserve Patients' Lives and Allografts |
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