Intraflagellar transport trains and motors: Insights from structure
Intraflagellar transport (IFT) sculpts the proteome of cilia and flagella; the antenna-like organelles found on the surface of virtually all human cell types. By delivering proteins to the growing ciliary tip, recycling turnover products, and selectively transporting signalling molecules, IFT has cr...
Gespeichert in:
| Veröffentlicht in: | Seminars in cell & developmental biology 2020-11, Vol.107, p.82-90 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 90 |
|---|---|
| container_issue | |
| container_start_page | 82 |
| container_title | Seminars in cell & developmental biology |
| container_volume | 107 |
| creator | Webb, Stephanie Mukhopadhyay, Aakash G. Roberts, Anthony J. |
| description | Intraflagellar transport (IFT) sculpts the proteome of cilia and flagella; the antenna-like organelles found on the surface of virtually all human cell types. By delivering proteins to the growing ciliary tip, recycling turnover products, and selectively transporting signalling molecules, IFT has critical roles in cilia biogenesis, quality control, and signal transduction. IFT involves long polymeric arrays, termed IFT trains, which move to and from the ciliary tip under the power of the microtubule-based motor proteins kinesin-II and dynein-2. Recent top-down and bottom-up structural biology approaches are converging on the molecular architecture of the IFT train machinery. Here we review these studies, with a focus on how kinesin-II and dynein-2 assemble, attach to IFT trains, and undergo precise regulation to mediate bidirectional transport. |
| doi_str_mv | 10.1016/j.semcdb.2020.05.021 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7561706</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1084952119301533</els_id><sourcerecordid>2425594213</sourcerecordid><originalsourceid>FETCH-LOGICAL-c463t-da52f9b3dd500c285a39fa1c7fd8799cf6865bfe5ebc474f372aa77cf7c666553</originalsourceid><addsrcrecordid>eNp9kE1P3DAQhi1UVGDpP0BVjr0k-NtJD0ho1cJKSFzgbDn-WLxK4q3trMS_J9EuW7hwmhnNzPvOPABcIVghiPj1pkq216atMMSwgqyCGJ2AcwQbXhJO6Lc5r2nZMIzOwEVKGwghbTD_Ds4I5jUlWJyD5WrIUblOrW3XqVhMxZC2IeY580Mq1GCKPuQQ0-9iNSS_fsmpcDH0Rcpx1HmM9hKcOtUl--MQF-D575-n5X358Hi3Wt4-lJpykkujGHZNS4xhEGpcM0Uap5AWztSiabTjNWets8y2mgrqiMBKCaGd0JxzxsgC3Ox1t2PbW6PtfHont9H3Kr7KoLz83Bn8i1yHnRSMIwH5JPDrIBDDv9GmLHuf9Pz4YMOYJKaYsYZiRKZRuh_VMaQUrTvaIChn_nIj9_zlzF9CJif-09rPjycel96B___BTqB23kaZtLeDtsZHq7M0wX_t8AZ44prp</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2425594213</pqid></control><display><type>article</type><title>Intraflagellar transport trains and motors: Insights from structure</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Webb, Stephanie ; Mukhopadhyay, Aakash G. ; Roberts, Anthony J.</creator><creatorcontrib>Webb, Stephanie ; Mukhopadhyay, Aakash G. ; Roberts, Anthony J.</creatorcontrib><description>Intraflagellar transport (IFT) sculpts the proteome of cilia and flagella; the antenna-like organelles found on the surface of virtually all human cell types. By delivering proteins to the growing ciliary tip, recycling turnover products, and selectively transporting signalling molecules, IFT has critical roles in cilia biogenesis, quality control, and signal transduction. IFT involves long polymeric arrays, termed IFT trains, which move to and from the ciliary tip under the power of the microtubule-based motor proteins kinesin-II and dynein-2. Recent top-down and bottom-up structural biology approaches are converging on the molecular architecture of the IFT train machinery. Here we review these studies, with a focus on how kinesin-II and dynein-2 assemble, attach to IFT trains, and undergo precise regulation to mediate bidirectional transport.</description><identifier>ISSN: 1084-9521</identifier><identifier>EISSN: 1096-3634</identifier><identifier>DOI: 10.1016/j.semcdb.2020.05.021</identifier><identifier>PMID: 32684327</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Biological Transport ; Cilia ; Dynein ; Flagella - metabolism ; Humans ; Intraflagellar transport ; Kinesin ; Microtubule ; Microtubules - metabolism ; Models, Biological ; Molecular Motor Proteins - metabolism ; Motor protein</subject><ispartof>Seminars in cell & developmental biology, 2020-11, Vol.107, p.82-90</ispartof><rights>2020 The Authors</rights><rights>Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><rights>2020 The Authors 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-da52f9b3dd500c285a39fa1c7fd8799cf6865bfe5ebc474f372aa77cf7c666553</citedby><cites>FETCH-LOGICAL-c463t-da52f9b3dd500c285a39fa1c7fd8799cf6865bfe5ebc474f372aa77cf7c666553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.semcdb.2020.05.021$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32684327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Webb, Stephanie</creatorcontrib><creatorcontrib>Mukhopadhyay, Aakash G.</creatorcontrib><creatorcontrib>Roberts, Anthony J.</creatorcontrib><title>Intraflagellar transport trains and motors: Insights from structure</title><title>Seminars in cell & developmental biology</title><addtitle>Semin Cell Dev Biol</addtitle><description>Intraflagellar transport (IFT) sculpts the proteome of cilia and flagella; the antenna-like organelles found on the surface of virtually all human cell types. By delivering proteins to the growing ciliary tip, recycling turnover products, and selectively transporting signalling molecules, IFT has critical roles in cilia biogenesis, quality control, and signal transduction. IFT involves long polymeric arrays, termed IFT trains, which move to and from the ciliary tip under the power of the microtubule-based motor proteins kinesin-II and dynein-2. Recent top-down and bottom-up structural biology approaches are converging on the molecular architecture of the IFT train machinery. Here we review these studies, with a focus on how kinesin-II and dynein-2 assemble, attach to IFT trains, and undergo precise regulation to mediate bidirectional transport.</description><subject>Animals</subject><subject>Biological Transport</subject><subject>Cilia</subject><subject>Dynein</subject><subject>Flagella - metabolism</subject><subject>Humans</subject><subject>Intraflagellar transport</subject><subject>Kinesin</subject><subject>Microtubule</subject><subject>Microtubules - metabolism</subject><subject>Models, Biological</subject><subject>Molecular Motor Proteins - metabolism</subject><subject>Motor protein</subject><issn>1084-9521</issn><issn>1096-3634</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhi1UVGDpP0BVjr0k-NtJD0ho1cJKSFzgbDn-WLxK4q3trMS_J9EuW7hwmhnNzPvOPABcIVghiPj1pkq216atMMSwgqyCGJ2AcwQbXhJO6Lc5r2nZMIzOwEVKGwghbTD_Ds4I5jUlWJyD5WrIUblOrW3XqVhMxZC2IeY580Mq1GCKPuQQ0-9iNSS_fsmpcDH0Rcpx1HmM9hKcOtUl--MQF-D575-n5X358Hi3Wt4-lJpykkujGHZNS4xhEGpcM0Uap5AWztSiabTjNWets8y2mgrqiMBKCaGd0JxzxsgC3Ox1t2PbW6PtfHont9H3Kr7KoLz83Bn8i1yHnRSMIwH5JPDrIBDDv9GmLHuf9Pz4YMOYJKaYsYZiRKZRuh_VMaQUrTvaIChn_nIj9_zlzF9CJif-09rPjycel96B___BTqB23kaZtLeDtsZHq7M0wX_t8AZ44prp</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Webb, Stephanie</creator><creator>Mukhopadhyay, Aakash G.</creator><creator>Roberts, Anthony J.</creator><general>Elsevier Ltd</general><general>Academic Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202011</creationdate><title>Intraflagellar transport trains and motors: Insights from structure</title><author>Webb, Stephanie ; Mukhopadhyay, Aakash G. ; Roberts, Anthony J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-da52f9b3dd500c285a39fa1c7fd8799cf6865bfe5ebc474f372aa77cf7c666553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Biological Transport</topic><topic>Cilia</topic><topic>Dynein</topic><topic>Flagella - metabolism</topic><topic>Humans</topic><topic>Intraflagellar transport</topic><topic>Kinesin</topic><topic>Microtubule</topic><topic>Microtubules - metabolism</topic><topic>Models, Biological</topic><topic>Molecular Motor Proteins - metabolism</topic><topic>Motor protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Webb, Stephanie</creatorcontrib><creatorcontrib>Mukhopadhyay, Aakash G.</creatorcontrib><creatorcontrib>Roberts, Anthony J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Seminars in cell & developmental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Webb, Stephanie</au><au>Mukhopadhyay, Aakash G.</au><au>Roberts, Anthony J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraflagellar transport trains and motors: Insights from structure</atitle><jtitle>Seminars in cell & developmental biology</jtitle><addtitle>Semin Cell Dev Biol</addtitle><date>2020-11</date><risdate>2020</risdate><volume>107</volume><spage>82</spage><epage>90</epage><pages>82-90</pages><issn>1084-9521</issn><eissn>1096-3634</eissn><abstract>Intraflagellar transport (IFT) sculpts the proteome of cilia and flagella; the antenna-like organelles found on the surface of virtually all human cell types. By delivering proteins to the growing ciliary tip, recycling turnover products, and selectively transporting signalling molecules, IFT has critical roles in cilia biogenesis, quality control, and signal transduction. IFT involves long polymeric arrays, termed IFT trains, which move to and from the ciliary tip under the power of the microtubule-based motor proteins kinesin-II and dynein-2. Recent top-down and bottom-up structural biology approaches are converging on the molecular architecture of the IFT train machinery. Here we review these studies, with a focus on how kinesin-II and dynein-2 assemble, attach to IFT trains, and undergo precise regulation to mediate bidirectional transport.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32684327</pmid><doi>10.1016/j.semcdb.2020.05.021</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1084-9521 |
| ispartof | Seminars in cell & developmental biology, 2020-11, Vol.107, p.82-90 |
| issn | 1084-9521 1096-3634 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7561706 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological Transport Cilia Dynein Flagella - metabolism Humans Intraflagellar transport Kinesin Microtubule Microtubules - metabolism Models, Biological Molecular Motor Proteins - metabolism Motor protein |
| title | Intraflagellar transport trains and motors: Insights from structure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T08%3A51%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intraflagellar%20transport%20trains%20and%20motors:%20Insights%20from%20structure&rft.jtitle=Seminars%20in%20cell%20&%20developmental%20biology&rft.au=Webb,%20Stephanie&rft.date=2020-11&rft.volume=107&rft.spage=82&rft.epage=90&rft.pages=82-90&rft.issn=1084-9521&rft.eissn=1096-3634&rft_id=info:doi/10.1016/j.semcdb.2020.05.021&rft_dat=%3Cproquest_pubme%3E2425594213%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2425594213&rft_id=info:pmid/32684327&rft_els_id=S1084952119301533&rfr_iscdi=true |