IRX3/5 regulate mitotic chromatid segregation and limb bud shape

Pattern formation is influenced by transcriptional regulation as well as by morphogenetic mechanisms that shape organ primordia, although factors that link these processes remain under-appreciated. Here we show that, apart from their established transcriptional roles in pattern formation, IRX3/5 hel...

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Veröffentlicht in:	Development (Cambridge) 2020-10, Vol.147 (19)
Hauptverfasser:	Tao, Hirotaka, Lambert, Jean-Philippe, Yung, Theodora M, Zhu, Min, Hahn, Noah A, Li, Danyi, Lau, Kimberly, Sturgeon, Kendra, Puviindran, Vijitha, Zhang, Xiaoyun, Gong, Wuming, Chen, Xiao Xiao, Anderson, Gregory, Garry, Daniel J, Henkelman, R Mark, Sun, Yu, Iulianella, Angelo, Kawakami, Yasuhiko, Gingras, Anne-Claude, Hui, Chi-Chung, Hopyan, Sevan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Chromatids - metabolism Chromosome Segregation - genetics Chromosome Segregation - physiology Female Fluorescent Antibody Technique HEK293 Cells Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Immunoprecipitation Limb Buds - embryology Limb Buds - metabolism Mass Spectrometry Mice Mitosis - genetics Mitosis - physiology Pregnancy Real-Time Polymerase Chain Reaction RNA-Seq Transcription Factors - genetics Transcription Factors - metabolism
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