Evaluation of the association between polymorphisms of PRM1 and PRM2 and the risk of male infertility: a systematic review, meta-analysis, and meta-regression
Studies have reported the genetic gives rise to male infertility. The aim of the present meta-analysis was to evaluate the association between PRM1 (rs737008 and rs2301365) and PRM2 (rs1646022 and rs2070923) polymorphisms and susceptibility to male infertility. The association between PRM1 and PRM2...
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| description | Studies have reported the genetic gives rise to male infertility. The aim of the present meta-analysis was to evaluate the association between
PRM1
(rs737008 and rs2301365) and
PRM2
(rs1646022 and rs2070923) polymorphisms and susceptibility to male infertility. The association between
PRM1
and
PRM2
polymorphisms and the risk of male infertility was evaluated using specific search terms in the Web of Science, Cochrane Library, PubMed, and Scopus databases without language restriction until January 28, 2020. The association was determined by odds ratio (OR) and 95% confidence interval (CI) on five genetic models using Review Manager 5.3 software. The funnel plot analysis and sensitivity analysis were done by the Comprehensive Meta-analysis 2.0 software. Out of 261 records retrieved from the databases, 17 studies were analyzed in the meta-analysis, including the four
PRM
polymorphisms. The pooled results as OR (
P
-value) showed 0.96 (0.44), 1.04 (0.70), 0.94 (0.51), 0.94 (0.48), and 1.03 (0.72) for
PRM1
rs737008 polymorphism and 1.67 (0.0007), 1.73 (0.06), 1.50 (0.007), 1.56 (0.004), and 1.62 (0.33) for
PRM1
rs2301365 polymorphism in allele, homozygous, heterozygous, recessive, and dominant models, respectively. Moreover, the pooled results as OR (
P
-value) showed 1.19 (0.004), 1.15 (0.26), 1.08 (0.70), 1.05 (0.76), and 0.98 (0.82) for
PRM2
rs1646022 and 0.88 (0.04), 0.84 (0.10), 1.05 (0.81), 0.90 (0.24), and 0.80 (0.02) for
PRM2
rs2070923 in allele, homozygous, heterozygous, recessive, and dominant models, respectively. The results showed
PRM1
rs2301365 and
PRM2
rs1646022 polymorphisms were associated with an elevated risk of male infertility and
PRM2
rs2070923 polymorphism had a protective role in infertile men. |
| doi_str_mv | 10.1038/s41598-020-74233-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7560625</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2451860264</sourcerecordid><originalsourceid>FETCH-LOGICAL-c494t-5f172f634cf6ca5db4a7beb3d8e3429a6b03a8d7ebc0663a60338c7ea70635673</originalsourceid><addsrcrecordid>eNp9Uc1u1DAQjhCIVqUvwAH5yKEBx3acLAckVJUfqQiE4GxNnMmuSxIvHmervAzPirMpVbngi0fz_cxovix7XvBXBZf1a1JFualzLnheKSFlLh9lp4KrMhdSiMcP6pPsnOiGp1eKjSo2T7MTKXlZca1Os99XB-gniM6PzHcs7pABkbdubTUYbxFHtvf9PPiw3zkaaCF-_fa5YDC2SyGOxSINjn4u6AA9Mjd2GKLrXZzfMGA0U8Qh2VoW8ODw9oINGCGHEfqZHF0cXY6tgNuARGmBZ9mTDnrC87v_LPvx_ur75cf8-suHT5fvrnOrNirmZVdUotNS2U5bKNtGQdVgI9sapRIb0A2XULcVNpZrLUFzKWtbIaQjyFJX8ix7u_rup2bA1uIYA_RmH9wAYTYenPkXGd3ObP3BVKXmWpTJ4OWdQfC_JqRoBkcW-x5G9BMZocqi1lxolahipdrgiQJ292MKbpZszZqtSdmaY7ZGJtGLhwveS_4mmQhyJVCCxi0Gc-OnkG5L_7P9A-B3ssU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2451860264</pqid></control><display><type>article</type><title>Evaluation of the association between polymorphisms of PRM1 and PRM2 and the risk of male infertility: a systematic review, meta-analysis, and meta-regression</title><source>MEDLINE</source><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><source>Springer Nature OA Free Journals</source><creator>Nemati, Houshang ; Sadeghi, Masoud ; Nazeri, Mehri ; Mohammadi, Mohana</creator><creatorcontrib>Nemati, Houshang ; Sadeghi, Masoud ; Nazeri, Mehri ; Mohammadi, Mohana</creatorcontrib><description>Studies have reported the genetic gives rise to male infertility. The aim of the present meta-analysis was to evaluate the association between
PRM1
(rs737008 and rs2301365) and
PRM2
(rs1646022 and rs2070923) polymorphisms and susceptibility to male infertility. The association between
PRM1
and
PRM2
polymorphisms and the risk of male infertility was evaluated using specific search terms in the Web of Science, Cochrane Library, PubMed, and Scopus databases without language restriction until January 28, 2020. The association was determined by odds ratio (OR) and 95% confidence interval (CI) on five genetic models using Review Manager 5.3 software. The funnel plot analysis and sensitivity analysis were done by the Comprehensive Meta-analysis 2.0 software. Out of 261 records retrieved from the databases, 17 studies were analyzed in the meta-analysis, including the four
PRM
polymorphisms. The pooled results as OR (
P
-value) showed 0.96 (0.44), 1.04 (0.70), 0.94 (0.51), 0.94 (0.48), and 1.03 (0.72) for
PRM1
rs737008 polymorphism and 1.67 (0.0007), 1.73 (0.06), 1.50 (0.007), 1.56 (0.004), and 1.62 (0.33) for
PRM1
rs2301365 polymorphism in allele, homozygous, heterozygous, recessive, and dominant models, respectively. Moreover, the pooled results as OR (
P
-value) showed 1.19 (0.004), 1.15 (0.26), 1.08 (0.70), 1.05 (0.76), and 0.98 (0.82) for
PRM2
rs1646022 and 0.88 (0.04), 0.84 (0.10), 1.05 (0.81), 0.90 (0.24), and 0.80 (0.02) for
PRM2
rs2070923 in allele, homozygous, heterozygous, recessive, and dominant models, respectively. The results showed
PRM1
rs2301365 and
PRM2
rs1646022 polymorphisms were associated with an elevated risk of male infertility and
PRM2
rs2070923 polymorphism had a protective role in infertile men.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-74233-3</identifier><identifier>PMID: 33057064</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208 ; 692/4017 ; Alleles ; Genes, Dominant ; Genes, Recessive ; Genetic Association Studies ; Genetic Predisposition to Disease - genetics ; Heterozygote ; Homozygote ; Humanities and Social Sciences ; Humans ; Infertility, Male - genetics ; Infertility, Male - prevention & control ; Male ; multidisciplinary ; Polymorphism, Genetic - genetics ; Protamines - genetics ; Regression Analysis ; Risk ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2020-10, Vol.10 (1), p.17228-17228, Article 17228</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-5f172f634cf6ca5db4a7beb3d8e3429a6b03a8d7ebc0663a60338c7ea70635673</citedby><cites>FETCH-LOGICAL-c494t-5f172f634cf6ca5db4a7beb3d8e3429a6b03a8d7ebc0663a60338c7ea70635673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560625/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560625/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33057064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nemati, Houshang</creatorcontrib><creatorcontrib>Sadeghi, Masoud</creatorcontrib><creatorcontrib>Nazeri, Mehri</creatorcontrib><creatorcontrib>Mohammadi, Mohana</creatorcontrib><title>Evaluation of the association between polymorphisms of PRM1 and PRM2 and the risk of male infertility: a systematic review, meta-analysis, and meta-regression</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Studies have reported the genetic gives rise to male infertility. The aim of the present meta-analysis was to evaluate the association between
PRM1
(rs737008 and rs2301365) and
PRM2
(rs1646022 and rs2070923) polymorphisms and susceptibility to male infertility. The association between
PRM1
and
PRM2
polymorphisms and the risk of male infertility was evaluated using specific search terms in the Web of Science, Cochrane Library, PubMed, and Scopus databases without language restriction until January 28, 2020. The association was determined by odds ratio (OR) and 95% confidence interval (CI) on five genetic models using Review Manager 5.3 software. The funnel plot analysis and sensitivity analysis were done by the Comprehensive Meta-analysis 2.0 software. Out of 261 records retrieved from the databases, 17 studies were analyzed in the meta-analysis, including the four
PRM
polymorphisms. The pooled results as OR (
P
-value) showed 0.96 (0.44), 1.04 (0.70), 0.94 (0.51), 0.94 (0.48), and 1.03 (0.72) for
PRM1
rs737008 polymorphism and 1.67 (0.0007), 1.73 (0.06), 1.50 (0.007), 1.56 (0.004), and 1.62 (0.33) for
PRM1
rs2301365 polymorphism in allele, homozygous, heterozygous, recessive, and dominant models, respectively. Moreover, the pooled results as OR (
P
-value) showed 1.19 (0.004), 1.15 (0.26), 1.08 (0.70), 1.05 (0.76), and 0.98 (0.82) for
PRM2
rs1646022 and 0.88 (0.04), 0.84 (0.10), 1.05 (0.81), 0.90 (0.24), and 0.80 (0.02) for
PRM2
rs2070923 in allele, homozygous, heterozygous, recessive, and dominant models, respectively. The results showed
PRM1
rs2301365 and
PRM2
rs1646022 polymorphisms were associated with an elevated risk of male infertility and
PRM2
rs2070923 polymorphism had a protective role in infertile men.</description><subject>631/208</subject><subject>692/4017</subject><subject>Alleles</subject><subject>Genes, Dominant</subject><subject>Genes, Recessive</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Heterozygote</subject><subject>Homozygote</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Infertility, Male - genetics</subject><subject>Infertility, Male - prevention & control</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Protamines - genetics</subject><subject>Regression Analysis</subject><subject>Risk</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9Uc1u1DAQjhCIVqUvwAH5yKEBx3acLAckVJUfqQiE4GxNnMmuSxIvHmervAzPirMpVbngi0fz_cxovix7XvBXBZf1a1JFualzLnheKSFlLh9lp4KrMhdSiMcP6pPsnOiGp1eKjSo2T7MTKXlZca1Os99XB-gniM6PzHcs7pABkbdubTUYbxFHtvf9PPiw3zkaaCF-_fa5YDC2SyGOxSINjn4u6AA9Mjd2GKLrXZzfMGA0U8Qh2VoW8ODw9oINGCGHEfqZHF0cXY6tgNuARGmBZ9mTDnrC87v_LPvx_ur75cf8-suHT5fvrnOrNirmZVdUotNS2U5bKNtGQdVgI9sapRIb0A2XULcVNpZrLUFzKWtbIaQjyFJX8ix7u_rup2bA1uIYA_RmH9wAYTYenPkXGd3ObP3BVKXmWpTJ4OWdQfC_JqRoBkcW-x5G9BMZocqi1lxolahipdrgiQJ292MKbpZszZqtSdmaY7ZGJtGLhwveS_4mmQhyJVCCxi0Gc-OnkG5L_7P9A-B3ssU</recordid><startdate>20201014</startdate><enddate>20201014</enddate><creator>Nemati, Houshang</creator><creator>Sadeghi, Masoud</creator><creator>Nazeri, Mehri</creator><creator>Mohammadi, Mohana</creator><general>Nature Publishing Group UK</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201014</creationdate><title>Evaluation of the association between polymorphisms of PRM1 and PRM2 and the risk of male infertility: a systematic review, meta-analysis, and meta-regression</title><author>Nemati, Houshang ; Sadeghi, Masoud ; Nazeri, Mehri ; Mohammadi, Mohana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-5f172f634cf6ca5db4a7beb3d8e3429a6b03a8d7ebc0663a60338c7ea70635673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/208</topic><topic>692/4017</topic><topic>Alleles</topic><topic>Genes, Dominant</topic><topic>Genes, Recessive</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Heterozygote</topic><topic>Homozygote</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Infertility, Male - genetics</topic><topic>Infertility, Male - prevention & control</topic><topic>Male</topic><topic>multidisciplinary</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Protamines - genetics</topic><topic>Regression Analysis</topic><topic>Risk</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nemati, Houshang</creatorcontrib><creatorcontrib>Sadeghi, Masoud</creatorcontrib><creatorcontrib>Nazeri, Mehri</creatorcontrib><creatorcontrib>Mohammadi, Mohana</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nemati, Houshang</au><au>Sadeghi, Masoud</au><au>Nazeri, Mehri</au><au>Mohammadi, Mohana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the association between polymorphisms of PRM1 and PRM2 and the risk of male infertility: a systematic review, meta-analysis, and meta-regression</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-10-14</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>17228</spage><epage>17228</epage><pages>17228-17228</pages><artnum>17228</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Studies have reported the genetic gives rise to male infertility. The aim of the present meta-analysis was to evaluate the association between
PRM1
(rs737008 and rs2301365) and
PRM2
(rs1646022 and rs2070923) polymorphisms and susceptibility to male infertility. The association between
PRM1
and
PRM2
polymorphisms and the risk of male infertility was evaluated using specific search terms in the Web of Science, Cochrane Library, PubMed, and Scopus databases without language restriction until January 28, 2020. The association was determined by odds ratio (OR) and 95% confidence interval (CI) on five genetic models using Review Manager 5.3 software. The funnel plot analysis and sensitivity analysis were done by the Comprehensive Meta-analysis 2.0 software. Out of 261 records retrieved from the databases, 17 studies were analyzed in the meta-analysis, including the four
PRM
polymorphisms. The pooled results as OR (
P
-value) showed 0.96 (0.44), 1.04 (0.70), 0.94 (0.51), 0.94 (0.48), and 1.03 (0.72) for
PRM1
rs737008 polymorphism and 1.67 (0.0007), 1.73 (0.06), 1.50 (0.007), 1.56 (0.004), and 1.62 (0.33) for
PRM1
rs2301365 polymorphism in allele, homozygous, heterozygous, recessive, and dominant models, respectively. Moreover, the pooled results as OR (
P
-value) showed 1.19 (0.004), 1.15 (0.26), 1.08 (0.70), 1.05 (0.76), and 0.98 (0.82) for
PRM2
rs1646022 and 0.88 (0.04), 0.84 (0.10), 1.05 (0.81), 0.90 (0.24), and 0.80 (0.02) for
PRM2
rs2070923 in allele, homozygous, heterozygous, recessive, and dominant models, respectively. The results showed
PRM1
rs2301365 and
PRM2
rs1646022 polymorphisms were associated with an elevated risk of male infertility and
PRM2
rs2070923 polymorphism had a protective role in infertile men.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33057064</pmid><doi>10.1038/s41598-020-74233-3</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Nature Free; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; Springer Nature OA Free Journals |
| subjects | 631/208 692/4017 Alleles Genes, Dominant Genes, Recessive Genetic Association Studies Genetic Predisposition to Disease - genetics Heterozygote Homozygote Humanities and Social Sciences Humans Infertility, Male - genetics Infertility, Male - prevention & control Male multidisciplinary Polymorphism, Genetic - genetics Protamines - genetics Regression Analysis Risk Science Science (multidisciplinary) |
| title | Evaluation of the association between polymorphisms of PRM1 and PRM2 and the risk of male infertility: a systematic review, meta-analysis, and meta-regression |
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