The tRNA pseudouridine synthase TruB1 regulates the maturation of let‐7 miRNA

Let‐7 is an evolutionary conserved microRNA that mediates post‐transcriptional gene silencing to regulate a wide range of biological processes, including development, differentiation, and tumor suppression. Let‐7 biogenesis is tightly regulated by several RNA‐binding proteins, including Lin28A/B, wh...

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Veröffentlicht in:	The EMBO journal 2020-10, Vol.39 (20), p.e104708-n/a
Hauptverfasser:	Kurimoto, Ryota, Chiba, Tomoki, Ito, Yoshiaki, Matsushima, Takahide, Yano, Yuki, Miyata, Kohei, Yashiro, Yuka, Suzuki, Tsutomu, Tomita, Kozo, Asahara, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Binding Biological activity Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Cell Survival Crosslinking EMBO36 Enzymatic activity Enzyme activity Evolutionary conservation Gene Knockdown Techniques Gene silencing Humans Immunoprecipitation Intramolecular Transferases - genetics Intramolecular Transferases - metabolism let‐7 Maturation microRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Protein Binding Proteins pseudouridine Pseudouridine synthase Pseudouridylation Recombinant Proteins Regulators Ribonucleic acid RNA RNA Processing, Post-Transcriptional - genetics RNA-binding protein RNA-Binding Proteins - metabolism tRNA TruB1 Tumor suppression
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