The Expression of Phospho-AKT, Phospho-mTOR, and PTEN in Extrahepatic Cholangiocarcinoma

Purpose: The protein kinase B (AKT) pathway plays a key role in the regulation of cellular survival, apoptosis, and protein translation, and has been shown to have prognostic significance in a number of cancers. We sought to define its role in extrahepatic cholangiocarcinoma. Experimental Design: Tw...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 2009-01, Vol.15 (2), p.660-667
Hauptverfasser:	Chung, Joon-Yong, Hong, Seung-Mo, Choi, Byeong Yeob, Cho, Hyungjun, Yu, Eunsil, Hewitt, Stephen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged AKT Antineoplastic agents Apoptosis Biological and medical sciences Cholangiocarcinoma - metabolism extrahepatic cholangiocarcinoma Female Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged mTOR Neoplasms - metabolism Oligonucleotide Array Sequence Analysis Pharmacology. Drug treatments Phosphorylation Protein Kinases - biosynthesis Protein Kinases - physiology proteomics Proteomics - methods Proto-Oncogene Proteins c-akt - biosynthesis Proto-Oncogene Proteins c-akt - physiology PTEN PTEN Phosphohydrolase - biosynthesis PTEN Phosphohydrolase - metabolism PTEN Phosphohydrolase - physiology TOR Serine-Threonine Kinases Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!