Interaction of TPPP3 with VDAC1 Promotes Endothelial Injury through Activation of Reactive Oxygen Species

Endothelial injury plays a critical role in the pathogenesis of cardiovascular disorders and metabolic-associated vascular complications which are the leading cause of death worldwide. However, the mechanism underlying endothelial dysfunction is not completely understood. The study is aimed at inves...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-13
Hauptverfasser:	Hu, Renming, Li, Rumei, Huang, Jinya, Zhou, Wenbai, Nan, Wu, Li, Yintao, Liu, Naijia, Zhou, Linuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Blood circulation disorders Cytoskeletal Proteins - antagonists & inhibitors Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Endothelium Experiments Flow cytometry Health aspects Human Umbilical Vein Endothelial Cells Humans Injuries Metabolism Neovascularization, Physiologic - drug effects Oxidative stress Oxidative Stress - drug effects Palmitic Acid - pharmacology Polymerization Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism RNA Interference RNA, Small Interfering - metabolism Saturated fatty acids Statistical analysis Up-Regulation - drug effects Voltage-Dependent Anion Channel 1 - antagonists & inhibitors Voltage-Dependent Anion Channel 1 - genetics Voltage-Dependent Anion Channel 1 - metabolism
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